POU domain, class 4, transcription factor 1

mammalian protein found in Mus musculus

Protein protein Q21986670

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Summary

POU domain, class 4, transcription factor 1 is a protein^[1].

Key Facts

POU domain, class 4, transcription factor 1's instance of is recorded as protein^[2].
POU domain, class 4, transcription factor 1's subclass of is recorded as protein^[3].
POU domain, class 4, transcription factor 1's UniProt protein ID is recorded as P17208^[4].
POU domain, class 4, transcription factor 1's part of is recorded as Lambda repressor-like, DNA-binding domain superfamily^[5].
POU domain, class 4, transcription factor 1's part of is recorded as Homeobox-like domain superfamily^[6].
POU domain, class 4, transcription factor 1's part of is recorded as POU domain, class 4, transcription factor 1^[7].
POU domain, class 4, transcription factor 1's part of is recorded as Homeobox domain, protein family^[8].
POU domain, class 4, transcription factor 1's part of is recorded as POU domain, protein family^[9].
POU domain, class 4, transcription factor 1's part of is recorded as POU-specific domain, protein family^[10].
POU domain, class 4, transcription factor 1's part of is recorded as Cro/C1-type helix-turn-helix domain, protein family^[11].
POU domain, class 4, transcription factor 1's part of is recorded as Homeobox, conserved site, protein family^[12].
POU domain, class 4, transcription factor 1's has part is recorded as Homeobox domain^[13].
POU domain, class 4, transcription factor 1's has part is recorded as Homeobox, conserved site^[14].
POU domain, class 4, transcription factor 1's has part is recorded as POU-specific domain^[15].
POU domain, class 4, transcription factor 1's has part is recorded as POU domain^[16].
POU domain, class 4, transcription factor 1's has part is recorded as Cro/C1-type helix-turn-helix domain^[17].
POU domain, class 4, transcription factor 1's RefSeq protein ID is recorded as NP_035273^[18].
POU domain, class 4, transcription factor 1's RefSeq protein ID is recorded as XP_006518768^[19].
POU domain, class 4, transcription factor 1's RefSeq protein ID is recorded as XP_006518769^[20].
POU domain, class 4, transcription factor 1's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[21].
POU domain, class 4, transcription factor 1's molecular function is recorded as DNA binding^[22].
POU domain, class 4, transcription factor 1's molecular function is recorded as DNA-binding transcription factor activity^[23].
POU domain, class 4, transcription factor 1's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[24].
POU domain, class 4, transcription factor 1's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[25].
POU domain, class 4, transcription factor 1's molecular function is recorded as protein binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Lambda repressor-like, DNA-binding domain superfamily, Homeobox-like domain superfamily, POU domain, class 4, transcription factor 1, Homeobox domain, protein family, POU domain, protein family, POU-specific domain, protein family, Cro/C1-type helix-turn-helix domain, protein family, Homeobox, conserved site, protein family

Properties

Biological process peripheral nervous system neuron development, regulation of transcription, DNA-templated, habenula development, trigeminal nerve development, neuron fate specification, ventricular compact myocardium morphogenesis, cell migration in hindbrain, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, transcription, DNA-templated, nervous system development, multicellular organism development, negative regulation of transcription elongation by RNA polymerase I, central nervous system neuron differentiation, neuron differentiation, positive regulation of apoptotic process, peripheral nervous system neuron differentiation, mesoderm development, innervation, proprioception involved in equilibrioception, regulation of neurogenesis, sensory system development, suckling behavior, transcription by RNA polymerase II, positive regulation of gene expression, neuron projection development, positive regulation of transcription by RNA polymerase II, negative regulation of programmed cell death, positive regulation of osteoclast differentiation, regulation of DNA-binding transcription factor activity, cellular response to cytokine stimulus, cellular response to estradiol stimulus, intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of transcription regulatory region DNA binding, negative regulation of neuron apoptotic process, development of the heart, negative regulation of gene expression

Cell component neuron projection, nucleus, cytoplasm

Encoded by Pou4f1

Found in taxon house mouse

Has part(s) Homeobox domain, Homeobox, conserved site, POU-specific domain, POU domain, Cro/C1-type helix-turn-helix domain

Imported from wholeness_audit_2026-05-02

Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, protein binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, chromatin binding, GTPase binding, DNA-binding transcription factor activity, RNA polymerase II-specific, single-stranded DNA binding, sequence-specific DNA binding, transcription coactivator activity, transcription corepressor activity, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSMUSP00000060798

Refseq protein id NP_035273, XP_006518768, XP_006518769

Uniprot protein id P17208

🏷️ Also known as

en brain-3A en brain-specific homeobox/POU domain protein 3A en Brn-3.0 en brn-3A en Pou4f1 en POU domain, class 4, transcription factor 1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ POU domain, class 4, transcription factor 1 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ POU domain, class 4, transcription factor 1 — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ POU domain, class 4, transcription factor 1 — UniProt protein ID (P352): P17208. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ POU domain, class 4, transcription factor 1 — part of (P361): Lambda repressor-like, DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ POU domain, class 4, transcription factor 1 — part of (P361): Homeobox-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ POU domain, class 4, transcription factor 1 — part of (P361): POU domain, class 4, transcription factor 1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ POU domain, class 4, transcription factor 1 — part of (P361): Homeobox domain, protein family. wikidata.org.
[9] ↑ POU domain, class 4, transcription factor 1 — part of (P361): POU domain, protein family. wikidata.org.
[10] ↑ POU domain, class 4, transcription factor 1 — part of (P361): POU-specific domain, protein family. wikidata.org.
[11] ↑ POU domain, class 4, transcription factor 1 — part of (P361): Cro/C1-type helix-turn-helix domain, protein family. wikidata.org.
[12] ↑ POU domain, class 4, transcription factor 1 — part of (P361): Homeobox, conserved site, protein family. wikidata.org.
[13] ↑ POU domain, class 4, transcription factor 1 — has part(s) (P527): Homeobox domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ POU domain, class 4, transcription factor 1 — has part(s) (P527): Homeobox, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ POU domain, class 4, transcription factor 1 — has part(s) (P527): POU-specific domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ POU domain, class 4, transcription factor 1 — has part(s) (P527): POU domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ POU domain, class 4, transcription factor 1 — has part(s) (P527): Cro/C1-type helix-turn-helix domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ POU domain, class 4, transcription factor 1 — RefSeq protein ID (P637): NP_035273. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ POU domain, class 4, transcription factor 1 — RefSeq protein ID (P637): XP_006518768. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ POU domain, class 4, transcription factor 1 — RefSeq protein ID (P637): XP_006518769. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ POU domain, class 4, transcription factor 1 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ POU domain, class 4, transcription factor 1 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ POU domain, class 4, transcription factor 1 — molecular function (P680): DNA-binding transcription factor activity. Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ POU domain, class 4, transcription factor 1 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ POU domain, class 4, transcription factor 1 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ POU domain, class 4, transcription factor 1 — molecular function (P680): protein binding. Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ POU domain, class 4, transcription factor 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_pou-domain-class-4-transcription-factor-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{POU domain, class 4, transcription factor 1}}, year = {2026}, url = {https://4ort.xyz/entity/pou-domain-class-4-transcription-factor-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): POU domain, class 4, transcription factor 1 — https://4ort.xyz/entity/pou-domain-class-4-transcription-factor-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/pou-domain-class-4-transcription-factor-1 · Last refreshed: May 3, 2026