Poly(A)-specific ribonuclease (deadenylation nuclease)

mammalian protein found in Mus musculus

Protein protein Q21989849

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Poly(A)-specific ribonuclease (deadenylation nuclease)

Summary

Poly(A)-specific ribonuclease (deadenylation nuclease) is a protein^[1].

Key Facts

Poly(A)-specific ribonuclease (deadenylation nuclease)'s instance of is recorded as protein^[2].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s subclass of is recorded as protein^[3].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s UniProt protein ID is recorded as Q8VDG3^[4].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s part of is recorded as Ribonuclease H superfamily^[5].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s part of is recorded as Ribonuclease H-like superfamily^[6].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s part of is recorded as RNA-binding domain superfamily^[7].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s part of is recorded as Ribonuclease CAF1^[8].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s part of is recorded as R3H domain superfamily^[9].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s part of is recorded as Nucleotide-binding alpha-beta plait domain superfamily^[10].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s part of is recorded as R3H domain, protein family^[11].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s part of is recorded as PARN, R3H domain, protein family^[12].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s part of is recorded as Poly(A)-specific ribonuclease, RNA-binding domain, protein family^[13].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s has part is recorded as R3H domain^[14].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s has part is recorded as Poly(A)-specific ribonuclease, RNA-binding^[15].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s has part is recorded as PARN, R3H domain^[16].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s RefSeq protein ID is recorded as NP_083037^[17].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s RefSeq protein ID is recorded as XP_006522715^[18].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s RefSeq protein ID is recorded as XP_017172634^[19].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s RefSeq protein ID is recorded as NP_001345381^[20].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s RefSeq protein ID is recorded as NP_001345382^[21].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s RefSeq protein ID is recorded as XP_030105165^[22].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s RefSeq protein ID is recorded as XP_036016049^[23].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s PDB structure ID is recorded as 1UG8^[24].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s PDB structure ID is recorded as 1WHV^[25].
Poly(A)-specific ribonuclease (deadenylation nuclease)'s PDB structure ID is recorded as 2ROK^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Ribonuclease H superfamily, Ribonuclease H-like superfamily, RNA-binding domain superfamily, Ribonuclease CAF1, R3H domain superfamily, Nucleotide-binding alpha-beta plait domain superfamily, R3H domain, protein family, PARN, R3H domain, protein family, Poly(A)-specific ribonuclease, RNA-binding domain, protein family

Properties

Biological process mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of telomere maintenance via telomerase, positive regulation of telomerase activity, RNA phosphodiester bond hydrolysis, exonucleolytic, telomerase RNA stabilization, regulation of telomerase RNA localization to Cajal body, ncRNA deadenylation, box H/ACA RNA 3'-end processing, miRNA catabolic process, polyadenylation-dependent snoRNA 3'-end processing, box H/ACA RNA 3'-end processing, miRNA catabolic process, polyadenylation-dependent snoRNA 3'-end processing, nuclear-transcribed mRNA poly(A) tail shortening

Cell component cytoplasm, nucleolus, nucleus, nucleolus, cytoplasm

Encoded by Parn

Found in taxon house mouse

Has part(s) R3H domain, Poly(A)-specific ribonuclease, RNA-binding, PARN, R3H domain

Imported from wholeness_audit_2026-05-02

Molecular function nuclease activity, exonuclease activity, protein binding, hydrolase activity, protein kinase binding, metal ion binding, nucleic acid binding, cation binding, poly(A)-specific ribonuclease activity, RNA binding, poly(A)-specific ribonuclease activity, 3'-5'-exoribonuclease activity, poly(A)-specific ribonuclease activity

External References (4)

Ensembl protein id ENSMUSP00000055969, ENSMUSP00000155076, ENSMUSP00000155335

Pdb structure id 1UG8, 1WHV, 2ROK, 3D45

Refseq protein id NP_083037, XP_006522715, XP_017172634, NP_001345381, NP_001345382, XP_030105165, XP_036016049

Uniprot protein id Q8VDG3

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — UniProt protein ID (P352): Q8VDG3. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — part of (P361): Ribonuclease H superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — part of (P361): Ribonuclease H-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — part of (P361): RNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — part of (P361): Ribonuclease CAF1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — part of (P361): R3H domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — part of (P361): Nucleotide-binding alpha-beta plait domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — part of (P361): R3H domain, protein family. wikidata.org.
[12] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — part of (P361): PARN, R3H domain, protein family. wikidata.org.
[13] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — part of (P361): Poly(A)-specific ribonuclease, RNA-binding domain, protein family. wikidata.org.
[14] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — has part(s) (P527): R3H domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — has part(s) (P527): Poly(A)-specific ribonuclease, RNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — has part(s) (P527): PARN, R3H domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — RefSeq protein ID (P637): NP_083037. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — RefSeq protein ID (P637): XP_006522715. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — RefSeq protein ID (P637): XP_017172634. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — RefSeq protein ID (P637): NP_001345381. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — RefSeq protein ID (P637): NP_001345382. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — RefSeq protein ID (P637): XP_030105165. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — RefSeq protein ID (P637): XP_036016049. Q20641742. Retrieved 2022-03-20. wikidata.org.
[24] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — PDB structure ID (P638): 1UG8. Q905695. Retrieved 2016-03-21. wikidata.org.
[25] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — PDB structure ID (P638): 1WHV. Q905695. Retrieved 2016-03-21. wikidata.org.
[26] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) — PDB structure ID (P638): 2ROK. Q905695. Retrieved 2016-03-21. wikidata.org.

Class ancestry

[1] ↑ Poly(A)-specific ribonuclease (deadenylation nuclease) is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Poly(A)-specific ribonuclease (deadenylation nuclease). Retrieved May 3, 2026, from https://4ort.xyz/entity/poly-a-specific-ribonuclease-deadenylation-nuclease-

MLA

“Poly(A)-specific ribonuclease (deadenylation nuclease).” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/poly-a-specific-ribonuclease-deadenylation-nuclease-.

BibTeX

@misc{4ortxyz_poly-a-specific-ribonuclease-deadenylation-nuclease-_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Poly(A)-specific ribonuclease (deadenylation nuclease)}}, year = {2026}, url = {https://4ort.xyz/entity/poly-a-specific-ribonuclease-deadenylation-nuclease-}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Poly(A)-specific ribonuclease (deadenylation nuclease) — https://4ort.xyz/entity/poly-a-specific-ribonuclease-deadenylation-nuclease- (retrieved 2026-05-03)

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