Polo like kinase 3

mammalian protein found in Homo sapiens
Protein protein Q21123280
Press Enter · cited answer in seconds

Summary

Polo like kinase 3 is a protein[1]. It is known by 8 alternative names across languages and contexts.[2]

Key Facts

  • Part of: Protein kinase-like domain superfamily[3], POLO box domain superfamily[4], serine/threonine-protein kinase Plk3[5], First polo-box domain, protein family[6], POLO box domain, protein family[7], Protein kinase domain, protein family[8], Second polo-box domain, protein family[9], Protein kinase, ATP binding site, protein family[10], Serine/threonine-protein kinase, active site, protein family[11]
  • Has part(s): Second polo-box domain[12], protein kinase, ATP binding site[13], protein kinase domain[14], serine/threonine-protein kinase, active site[15], POLO box domain[16], First polo-box domain[17]
  • Molecular function: transferase activity[18], nucleotide binding[19], protein kinase activity[20], p53 binding[21], kinase activity[22], protein serine/threonine kinase activity[23], protein binding[24], ATP binding[25]
  • Cell component: cytoplasm[26], centrosome[27], Golgi apparatus[28], microtubule organizing center[29], soma[30], dendrite[31], nucleolus[32], Golgi stack[33], cytoskeleton[34], nucleus[35], nucleoplasm[36], spindle pole[37]
  • Biological process: positive regulation of intracellular protein transport[38], regulation of cytokinesis[39], regulation of cell division[40], protein kinase B signaling[41], phosphorylation[42], response to reactive oxygen species[43], mitotic cell cycle checkpoint signaling[44], mitotic G1/S transition checkpoint signaling[45], positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia[46], negative regulation of apoptotic process[47], negative regulation of transcription by RNA polymerase II[48], cellular response to DNA damage stimulus[49], response to osmotic stress[50], protein phosphorylation[51]
  • Encoded by: PLK3[52]
  • Found in taxon: Homo sapiens[53]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . wikidata.org.
  8. [10] ↑ . wikidata.org.
  9. [11] ↑ . wikidata.org.
  10. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [41] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [42] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [43] ↑ . Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  42. [44] ↑ . Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  43. [45] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  44. [46] ↑ . Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  45. [47] ↑ . Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  46. [48] ↑ . Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  47. [49] ↑ . Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  48. [50] ↑ . Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  49. [51] ↑ . Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  50. [52] ↑ . UniProt. Retrieved . wikidata.org.
  51. [53] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Polo like kinase 3. Retrieved May 3, 2026, from https://4ort.xyz/entity/polo-like-kinase-3-q21123280
MLA “Polo like kinase 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/polo-like-kinase-3-q21123280.
BibTeX @misc{4ortxyz_polo-like-kinase-3-q21123280_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Polo like kinase 3}}, year = {2026}, url = {https://4ort.xyz/entity/polo-like-kinase-3-q21123280}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Polo like kinase 3 — https://4ort.xyz/entity/polo-like-kinase-3-q21123280 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/polo-like-kinase-3-q21123280 · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 13w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → PLK3
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → transferase activity, nucleotide binding, protein kinase activity +6
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 2.7.11.21, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.