Pleiotrophin

mammalian protein found in Rattus norvegicus

Protein protein Q28560285

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Pleiotrophin

Summary

Pleiotrophin is a protein^[1].

Key Facts

Pleiotrophin's instance of is recorded as protein^[2].
Pleiotrophin's UniProt protein ID is recorded as P63090^[3].
Pleiotrophin's part of is recorded as Midkine heparin-binding growth factor^[4].
Pleiotrophin's part of is recorded as Pleiotrophin/Midkine disulphide-rich domain superfamily^[5].
Pleiotrophin's part of is recorded as Pleiotrophin/Midkine, N-terminal domain superfamily^[6].
Pleiotrophin's part of is recorded as Pleiotrophin/Midkine, C-terminal domain superfamily^[7].
Pleiotrophin's part of is recorded as membrane protein^[8].
Pleiotrophin's part of is recorded as Pleiotrophin/Midkine, C-terminal domain, protein family^[9].
Pleiotrophin's part of is recorded as Pleiotrophin/Midkine, N-terminal domain, protein family^[10].
Pleiotrophin's part of is recorded as Pleiotrophin/Midkine heparin-binding growth factor, conserved site, protein family^[11].
Pleiotrophin's has part is recorded as Pleiotrophin/Midkine, N-terminal domain^[12].
Pleiotrophin's has part is recorded as Pleiotrophin/Midkine heparin-binding growth factor, conserved site^[13].
Pleiotrophin's has part is recorded as Pleiotrophin/Midkine, C-terminal domain^[14].
Pleiotrophin's RefSeq protein ID is recorded as NP_058762^[15].
Pleiotrophin's RefSeq protein ID is recorded as XP_017447964^[16].
Pleiotrophin's RefSeq protein ID is recorded as XP_038963004^[17].
Pleiotrophin's RefSeq protein ID is recorded as XP_038963005^[18].
Pleiotrophin's RefSeq protein ID is recorded as XP_038963006^[19].
Pleiotrophin's molecular function is recorded as protein binding^[20].
Pleiotrophin's molecular function is recorded as glycosaminoglycan binding^[21].
Pleiotrophin's molecular function is recorded as growth factor activity^[22].
Pleiotrophin's molecular function is recorded as heparin binding^[23].
Pleiotrophin's molecular function is recorded as protein kinase binding^[24].
Pleiotrophin's molecular function is recorded as chondroitin sulfate proteoglycan binding^[25].
Pleiotrophin's molecular function is recorded as chondroitin sulfate binding^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of Midkine heparin-binding growth factor, Pleiotrophin/Midkine disulphide-rich domain superfamily, Pleiotrophin/Midkine, N-terminal domain superfamily, Pleiotrophin/Midkine, C-terminal domain superfamily, membrane protein, Pleiotrophin/Midkine, C-terminal domain, protein family, Pleiotrophin/Midkine, N-terminal domain, protein family, Pleiotrophin/Midkine heparin-binding growth factor, conserved site, protein family

Properties

Biological process ossification, liver development, brain development, development of the heart, learning, positive regulation of cell population proliferation, regulation of cell shape, regulation of signaling receptor activity, positive regulation of cell-substrate adhesion, positive regulation of neuron projection development, response to activity, negative regulation of angiogenesis, spinal cord development, cerebellum development, thalamus development, bone mineralization, lung development, negative regulation of cell migration, hindbrain development, response to estradiol, response to progesterone, cellular response to UV, cellular response to platelet-derived growth factor stimulus, positive regulation of apoptotic process, estrous cycle, endothelial cell differentiation, negative regulation of membrane potential, negative regulation of epithelial cell proliferation, positive regulation of cell division, retina development in camera-type eye, retinal rod cell differentiation, negative regulation of glial cell proliferation, long-term potentiation, cellular response to vitamin D, cellular response to organic cyclic compound, cellular response to hypoxia, negative regulation of mesenchymal cell proliferation, response to kainic acid, rod bipolar cell differentiation, response to ciliary neurotrophic factor, positive regulation of skeletal muscle acetylcholine-gated channel clustering, negative regulation of neuromuscular junction development, response to nerve growth factor, positive regulation of hepatocyte proliferation, leukocyte chemotaxis involved in inflammatory response, positive regulation of leukocyte chemotaxis, integrin-mediated signaling pathway, negative regulation of neuroblast proliferation, learning, memory, regulation of endothelial cell migration, response to auditory stimulus, positive regulation of bone mineralization, dendrite regeneration, regulation of myelination, negative regulation of phosphoprotein phosphatase activity, tissue regeneration, receptor clustering, ossification involved in bone remodeling, estrous cycle, positive regulation of cell differentiation, positive regulation of ossification, decidualization, regulation of synaptic plasticity, oogenesis, positive regulation of axon regeneration, positive regulation of oligodendrocyte differentiation, dendrite arborization, positive regulation of dendrite development, negative regulation of long-term synaptic potentiation, regulation of hemopoiesis, regulation of stem cell population maintenance, positive regulation of hepatocyte proliferation, positive regulation of stem cell differentiation

Cell component extracellular region, basement membrane, extracellular space, cytoplasm, endoplasmic reticulum, cell surface, membrane, neuromuscular junction, protein-containing complex, perinuclear region of cytoplasm, presynapse, postsynapse, plasma membrane

Encoded by Ptn

Found in taxon brown rat

Has part(s) Pleiotrophin/Midkine, N-terminal domain, Pleiotrophin/Midkine heparin-binding growth factor, conserved site, Pleiotrophin/Midkine, C-terminal domain

Imported from wholeness_audit_2026-05-02

Molecular function protein binding, glycosaminoglycan binding, growth factor activity, heparin binding, protein kinase binding, chondroitin sulfate proteoglycan binding, chondroitin sulfate binding, vascular endothelial growth factor binding, proteoglycan binding, heparan sulfate binding, protein phosphatase inhibitor activity, integrin binding, syndecan binding

External References (3)

Ensembl protein id ENSRNOP00000016088, ENSRNOP00000080308

Refseq protein id NP_058762, XP_017447964, XP_038963004, XP_038963005, XP_038963006

Uniprot protein id P63090

🏷️ Also known as

en HBBM en HB-GAM en HBGF-8 en heparin affine regulatory peptide en heparin-binding brain mitogen en heparin binding factor en heparin-binding growth-associated molecule en heparin-binding growth factor 8 en heparin-binding neurotrophic factor en heparin-binding neutrophic factor en OSF-1 en osteoblast-specific factor 1 en Pleiotrophin en Pleiotrophin (Heparine binding factor, Hbnf, in the mouse) en Ptn

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Pleiotrophin — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Pleiotrophin — UniProt protein ID (P352): P63090. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Pleiotrophin — part of (P361): Midkine heparin-binding growth factor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Pleiotrophin — part of (P361): Pleiotrophin/Midkine disulphide-rich domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Pleiotrophin — part of (P361): Pleiotrophin/Midkine, N-terminal domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Pleiotrophin — part of (P361): Pleiotrophin/Midkine, C-terminal domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Pleiotrophin — part of (P361): membrane protein. wikidata.org.
[9] ↑ Pleiotrophin — part of (P361): Pleiotrophin/Midkine, C-terminal domain, protein family. wikidata.org.
[10] ↑ Pleiotrophin — part of (P361): Pleiotrophin/Midkine, N-terminal domain, protein family. wikidata.org.
[11] ↑ Pleiotrophin — part of (P361): Pleiotrophin/Midkine heparin-binding growth factor, conserved site, protein family. wikidata.org.
[12] ↑ Pleiotrophin — has part(s) (P527): Pleiotrophin/Midkine, N-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Pleiotrophin — has part(s) (P527): Pleiotrophin/Midkine heparin-binding growth factor, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Pleiotrophin — has part(s) (P527): Pleiotrophin/Midkine, C-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Pleiotrophin — RefSeq protein ID (P637): NP_058762. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Pleiotrophin — RefSeq protein ID (P637): XP_017447964. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Pleiotrophin — RefSeq protein ID (P637): XP_038963004. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Pleiotrophin — RefSeq protein ID (P637): XP_038963005. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Pleiotrophin — RefSeq protein ID (P637): XP_038963006. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Pleiotrophin — molecular function (P680): protein binding. Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3). Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Pleiotrophin — molecular function (P680): glycosaminoglycan binding. Receptor binding of osteoblast-specific factor 1 (OSF-1/HB-GAM) to human osteosarcoma cells promotes cell attachment. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Pleiotrophin — molecular function (P680): growth factor activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Pleiotrophin — molecular function (P680): heparin binding. Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Pleiotrophin — molecular function (P680): protein kinase binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Pleiotrophin — molecular function (P680): chondroitin sulfate proteoglycan binding. Neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, interacts with pleiotrophin, a heparin-binding growth factor. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Pleiotrophin — molecular function (P680): chondroitin sulfate binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Pleiotrophin is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Pleiotrophin. Retrieved May 3, 2026, from https://4ort.xyz/entity/pleiotrophin

MLA “Pleiotrophin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/pleiotrophin.

BibTeX

@misc{4ortxyz_pleiotrophin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Pleiotrophin}}, year = {2026}, url = {https://4ort.xyz/entity/pleiotrophin}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Pleiotrophin — https://4ort.xyz/entity/pleiotrophin (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/pleiotrophin · Last refreshed: May 3, 2026