Phospholipase C, gamma 2

mammalian protein found in Mus musculus

Protein protein Q21981083

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Phospholipase C, gamma 2

Summary

Phospholipase C, gamma 2 is a protein^[1].

Key Facts

Phospholipase C, gamma 2's instance of is recorded as protein^[2].
Phospholipase C, gamma 2's UniProt protein ID is recorded as Q8CIH5^[3].
Phospholipase C, gamma 2's part of is recorded as SH3-like domain superfamily^[4].
Phospholipase C, gamma 2's part of is recorded as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2^[5].
Phospholipase C, gamma 2's part of is recorded as PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily^[6].
Phospholipase C, gamma 2's part of is recorded as SH2 domain superfamily^[7].
Phospholipase C, gamma 2's part of is recorded as C2 domain superfamily^[8].
Phospholipase C, gamma 2's part of is recorded as PH-like domain superfamily^[9].
Phospholipase C, gamma 2's part of is recorded as EF-hand domain pair^[10].
Phospholipase C, gamma 2's part of is recorded as membrane protein^[11].
Phospholipase C, gamma 2's part of is recorded as pleckstrin homology domain, protein family^[12].
Phospholipase C, gamma 2's part of is recorded as SH2 domain, protein family^[13].
Phospholipase C, gamma 2's part of is recorded as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain, protein family^[14].
Phospholipase C, gamma 2's part of is recorded as C2 domain, protein family^[15].
Phospholipase C, gamma 2's part of is recorded as PLC-gamma, C-terminal SH2 domain, protein family^[16].
Phospholipase C, gamma 2's part of is recorded as Phosphatidylinositol-specific phospholipase C, X domain, protein family^[17].
Phospholipase C, gamma 2's part of is recorded as PLC-gamma, N-terminal SH2 domain, protein family^[18].
Phospholipase C, gamma 2's part of is recorded as Phospholipase C, phosphatidylinositol-specific, Y domain, protein family^[19].
Phospholipase C, gamma 2's part of is recorded as SH3 domain, protein family^[20].
Phospholipase C, gamma 2's has part is recorded as SH2 domain^[21].
Phospholipase C, gamma 2's has part is recorded as Phospholipase C, phosphatidylinositol-specific, Y domain^[22].
Phospholipase C, gamma 2's has part is recorded as SH3 domain^[23].
Phospholipase C, gamma 2's has part is recorded as pleckstrin homology domain^[24].
Phospholipase C, gamma 2's has part is recorded as C2 domain^[25].
Phospholipase C, gamma 2's has part is recorded as Phosphatidylinositol-specific phospholipase C, X domain^[26].

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Quick Facts

Instance of protein

Part of SH3-like domain superfamily, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily, SH2 domain superfamily, C2 domain superfamily, PH-like domain superfamily, EF-hand domain pair, membrane protein, pleckstrin homology domain, protein family, SH2 domain, protein family, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain, protein family, C2 domain, protein family, PLC-gamma, C-terminal SH2 domain, protein family, Phosphatidylinositol-specific phospholipase C, X domain, protein family, PLC-gamma, N-terminal SH2 domain, protein family, Phospholipase C, phosphatidylinositol-specific, Y domain, protein family, SH3 domain, protein family

Properties

Biological process B cell receptor signaling pathway, release of sequestered calcium ion into cytosol, intracellular signal transduction, inositol trisphosphate biosynthetic process, positive regulation of receptor internalization, lipid metabolism, lipid catabolic process, follicular B cell differentiation, response to lipopolysaccharide, phospholipid catabolic process, regulation of gene expression, phosphatidylinositol biosynthetic process, negative regulation of programmed cell death, B cell differentiation, T cell receptor signaling pathway, activation of store-operated calcium channel activity, positive regulation of type I interferon production, signal transduction, positive regulation of cytosolic calcium ion concentration, response to magnesium ion, response to ATP, release of sequestered calcium ion into cytosol, inositol trisphosphate biosynthetic process, phosphatidylinositol-mediated signaling

Cell component plasma membrane, cytosol, membrane, plasma membrane

Encoded by Plcg2

Found in taxon house mouse

Has part(s) SH2 domain, Phospholipase C, phosphatidylinositol-specific, Y domain, SH3 domain, pleckstrin homology domain, C2 domain, Phosphatidylinositol-specific phospholipase C, X domain, PLC-gamma, N-terminal SH2 domain, PLC-gamma, C-terminal SH2 domain, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain

Imported from wholeness_audit_2026-05-02

Molecular function signal transducer activity, protein binding, phosphoric diester hydrolase activity, phospholipase C activity, hydrolase activity, phosphatidylinositol phospholipase C activity, phosphotyrosine residue binding, phosphatidylinositol phospholipase C activity, protein binding

External References (4)

Ensembl protein id ENSMUSP00000079991

Pdb structure id 2DX0, 2EQI

Refseq protein id NP_758489

Uniprot protein id Q8CIH5

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Phospholipase C, gamma 2 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Phospholipase C, gamma 2 — UniProt protein ID (P352): Q8CIH5. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Phospholipase C, gamma 2 — part of (P361): SH3-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Phospholipase C, gamma 2 — part of (P361): 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Phospholipase C, gamma 2 — part of (P361): PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Phospholipase C, gamma 2 — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Phospholipase C, gamma 2 — part of (P361): C2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Phospholipase C, gamma 2 — part of (P361): PH-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Phospholipase C, gamma 2 — part of (P361): EF-hand domain pair. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Phospholipase C, gamma 2 — part of (P361): membrane protein. wikidata.org.
[12] ↑ Phospholipase C, gamma 2 — part of (P361): pleckstrin homology domain, protein family. wikidata.org.
[13] ↑ Phospholipase C, gamma 2 — part of (P361): SH2 domain, protein family. wikidata.org.
[14] ↑ Phospholipase C, gamma 2 — part of (P361): 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain, protein family. wikidata.org.
[15] ↑ Phospholipase C, gamma 2 — part of (P361): C2 domain, protein family. wikidata.org.
[16] ↑ Phospholipase C, gamma 2 — part of (P361): PLC-gamma, C-terminal SH2 domain, protein family. wikidata.org.
[17] ↑ Phospholipase C, gamma 2 — part of (P361): Phosphatidylinositol-specific phospholipase C, X domain, protein family. wikidata.org.
[18] ↑ Phospholipase C, gamma 2 — part of (P361): PLC-gamma, N-terminal SH2 domain, protein family. wikidata.org.
[19] ↑ Phospholipase C, gamma 2 — part of (P361): Phospholipase C, phosphatidylinositol-specific, Y domain, protein family. wikidata.org.
[20] ↑ Phospholipase C, gamma 2 — part of (P361): SH3 domain, protein family. wikidata.org.
[21] ↑ Phospholipase C, gamma 2 — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Phospholipase C, gamma 2 — has part(s) (P527): Phospholipase C, phosphatidylinositol-specific, Y domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Phospholipase C, gamma 2 — has part(s) (P527): SH3 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Phospholipase C, gamma 2 — has part(s) (P527): pleckstrin homology domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Phospholipase C, gamma 2 — has part(s) (P527): C2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Phospholipase C, gamma 2 — has part(s) (P527): Phosphatidylinositol-specific phospholipase C, X domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Phospholipase C, gamma 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Phospholipase C, gamma 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/phospholipase-c-gamma-2-q21981083

MLA

“Phospholipase C, gamma 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/phospholipase-c-gamma-2-q21981083.

BibTeX

@misc{4ortxyz_phospholipase-c-gamma-2-q21981083_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Phospholipase C, gamma 2}}, year = {2026}, url = {https://4ort.xyz/entity/phospholipase-c-gamma-2-q21981083}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Phospholipase C, gamma 2 — https://4ort.xyz/entity/phospholipase-c-gamma-2-q21981083 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/phospholipase-c-gamma-2-q21981083 · Last refreshed: May 3, 2026