Phosphodiesterase 5A, cGMP-specific

mammalian protein found in Mus musculus

Protein protein Q14865589

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Phosphodiesterase 5A, cGMP-specific

Summary

Phosphodiesterase 5A, cGMP-specific is a protein^[1].

Key Facts

Phosphodiesterase 5A, cGMP-specific's instance of is recorded as protein^[2].
Phosphodiesterase 5A, cGMP-specific's subclass of is recorded as protein^[3].
Phosphodiesterase 5A, cGMP-specific's UniProt protein ID is recorded as Q8CG03^[4].
Phosphodiesterase 5A, cGMP-specific's part of is recorded as 3'5'-cyclic nucleotide phosphodiesterase^[5].
Phosphodiesterase 5A, cGMP-specific's part of is recorded as 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily^[6].
Phosphodiesterase 5A, cGMP-specific's part of is recorded as GAF-like domain superfamily^[7].
Phosphodiesterase 5A, cGMP-specific's part of is recorded as 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family^[8].
Phosphodiesterase 5A, cGMP-specific's part of is recorded as HD/PDEase domain, protein family^[9].
Phosphodiesterase 5A, cGMP-specific's part of is recorded as GAF domain, protein family^[10].
Phosphodiesterase 5A, cGMP-specific's part of is recorded as 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family^[11].
Phosphodiesterase 5A, cGMP-specific's has part is recorded as 3'5'-cyclic nucleotide phosphodiesterase, conserved site^[12].
Phosphodiesterase 5A, cGMP-specific's has part is recorded as 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain^[13].
Phosphodiesterase 5A, cGMP-specific's has part is recorded as HD/PDEase domain^[14].
Phosphodiesterase 5A, cGMP-specific's has part is recorded as GAF domain^[15].
Phosphodiesterase 5A, cGMP-specific's RefSeq protein ID is recorded as NP_700471^[16].
Phosphodiesterase 5A, cGMP-specific's RefSeq protein ID is recorded as XP_006501544^[17].
Phosphodiesterase 5A, cGMP-specific's PDB structure ID is recorded as 2K31^[18].
Phosphodiesterase 5A, cGMP-specific's molecular function is recorded as nucleotide binding^[19].
Phosphodiesterase 5A, cGMP-specific's molecular function is recorded as 3',5'-cyclic-nucleotide phosphodiesterase activity^[20].
Phosphodiesterase 5A, cGMP-specific's molecular function is recorded as cGMP binding^[21].
Phosphodiesterase 5A, cGMP-specific's molecular function is recorded as metal ion binding^[22].
Phosphodiesterase 5A, cGMP-specific's molecular function is recorded as cyclic-nucleotide phosphodiesterase activity^[23].
Phosphodiesterase 5A, cGMP-specific's molecular function is recorded as catalytic activity^[24].
Phosphodiesterase 5A, cGMP-specific's molecular function is recorded as phosphoric diester hydrolase activity^[25].
Phosphodiesterase 5A, cGMP-specific's molecular function is recorded as hydrolase activity^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of 3'5'-cyclic nucleotide phosphodiesterase, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily, GAF-like domain superfamily, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family, HD/PDEase domain, protein family, GAF domain, protein family, 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

Properties

Biological process positive regulation of MAP kinase activity, cGMP metabolic process, cGMP catabolic process, positive regulation of cardiac muscle hypertrophy, negative regulation of T cell proliferation, positive regulation of G protein-coupled receptor signaling pathway, positive regulation of oocyte development, metabolism, relaxation of cardiac muscle, signal transduction, negative regulation of cardiac muscle contraction, regulation of the force of heart contraction, positive regulation of chronic inflammatory response, short-term memory, positive regulation of apoptotic process, positive regulation of vasoconstriction, regulation of nitric oxide mediated signal transduction, cGMP catabolic process

Cell component cytosol

Encoded by Pde5a

Found in taxon house mouse

Has part(s) 3'5'-cyclic nucleotide phosphodiesterase, conserved site, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, HD/PDEase domain, GAF domain

Imported from wholeness_audit_2026-05-02

Molecular function nucleotide binding, 3',5'-cyclic-nucleotide phosphodiesterase activity, cGMP binding, metal ion binding, cyclic-nucleotide phosphodiesterase activity, catalytic activity, phosphoric diester hydrolase activity, hydrolase activity, 3',5'-cyclic-GMP phosphodiesterase activity, cGMP binding, 3',5'-cyclic-GMP phosphodiesterase activity

External References (4)

Ensembl protein id ENSMUSP00000069011, ENSMUSP00000143042

Pdb structure id 2K31

Refseq protein id NP_700471, XP_006501544

Uniprot protein id Q8CG03

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Phosphodiesterase 5A, cGMP-specific — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Phosphodiesterase 5A, cGMP-specific — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Phosphodiesterase 5A, cGMP-specific — UniProt protein ID (P352): Q8CG03. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Phosphodiesterase 5A, cGMP-specific — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Phosphodiesterase 5A, cGMP-specific — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Phosphodiesterase 5A, cGMP-specific — part of (P361): GAF-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Phosphodiesterase 5A, cGMP-specific — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family. wikidata.org.
[9] ↑ Phosphodiesterase 5A, cGMP-specific — part of (P361): HD/PDEase domain, protein family. wikidata.org.
[10] ↑ Phosphodiesterase 5A, cGMP-specific — part of (P361): GAF domain, protein family. wikidata.org.
[11] ↑ Phosphodiesterase 5A, cGMP-specific — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family. wikidata.org.
[12] ↑ Phosphodiesterase 5A, cGMP-specific — has part(s) (P527): 3'5'-cyclic nucleotide phosphodiesterase, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Phosphodiesterase 5A, cGMP-specific — has part(s) (P527): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Phosphodiesterase 5A, cGMP-specific — has part(s) (P527): HD/PDEase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Phosphodiesterase 5A, cGMP-specific — has part(s) (P527): GAF domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Phosphodiesterase 5A, cGMP-specific — RefSeq protein ID (P637): NP_700471. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Phosphodiesterase 5A, cGMP-specific — RefSeq protein ID (P637): XP_006501544. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Phosphodiesterase 5A, cGMP-specific — PDB structure ID (P638): 2K31. Q905695. Retrieved 2016-08-10. wikidata.org.
[19] ↑ Phosphodiesterase 5A, cGMP-specific — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Phosphodiesterase 5A, cGMP-specific — molecular function (P680): 3',5'-cyclic-nucleotide phosphodiesterase activity. Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Phosphodiesterase 5A, cGMP-specific — molecular function (P680): cGMP binding. GOA. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Phosphodiesterase 5A, cGMP-specific — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Phosphodiesterase 5A, cGMP-specific — molecular function (P680): cyclic-nucleotide phosphodiesterase activity. PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Phosphodiesterase 5A, cGMP-specific — molecular function (P680): catalytic activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Phosphodiesterase 5A, cGMP-specific — molecular function (P680): phosphoric diester hydrolase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Phosphodiesterase 5A, cGMP-specific — molecular function (P680): hydrolase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Phosphodiesterase 5A, cGMP-specific is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Phosphodiesterase 5A, cGMP-specific. Retrieved May 3, 2026, from https://4ort.xyz/entity/phosphodiesterase-5a-cgmp-specific

MLA

“Phosphodiesterase 5A, cGMP-specific.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/phosphodiesterase-5a-cgmp-specific.

BibTeX

@misc{4ortxyz_phosphodiesterase-5a-cgmp-specific_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Phosphodiesterase 5A, cGMP-specific}}, year = {2026}, url = {https://4ort.xyz/entity/phosphodiesterase-5a-cgmp-specific}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Phosphodiesterase 5A, cGMP-specific — https://4ort.xyz/entity/phosphodiesterase-5a-cgmp-specific (retrieved 2026-05-03)

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