Phosphodiesterase 2A, cGMP-stimulated

mammalian protein found in Mus musculus

Protein protein Q21985968

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Phosphodiesterase 2A, cGMP-stimulated

Summary

Phosphodiesterase 2A, cGMP-stimulated is a protein^[1].

Key Facts

Phosphodiesterase 2A, cGMP-stimulated's instance of is recorded as protein^[2].
Phosphodiesterase 2A, cGMP-stimulated's UniProt protein ID is recorded as Q922S4^[3].
Phosphodiesterase 2A, cGMP-stimulated's part of is recorded as 3'5'-cyclic nucleotide phosphodiesterase^[4].
Phosphodiesterase 2A, cGMP-stimulated's part of is recorded as 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily^[5].
Phosphodiesterase 2A, cGMP-stimulated's part of is recorded as GAF-like domain superfamily^[6].
Phosphodiesterase 2A, cGMP-stimulated's part of is recorded as membrane protein^[7].
Phosphodiesterase 2A, cGMP-stimulated's part of is recorded as 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family^[8].
Phosphodiesterase 2A, cGMP-stimulated's part of is recorded as HD/PDEase domain, protein family^[9].
Phosphodiesterase 2A, cGMP-stimulated's part of is recorded as GAF domain, protein family^[10].
Phosphodiesterase 2A, cGMP-stimulated's part of is recorded as 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family^[11].
Phosphodiesterase 2A, cGMP-stimulated's has part is recorded as 3'5'-cyclic nucleotide phosphodiesterase, conserved site^[12].
Phosphodiesterase 2A, cGMP-stimulated's has part is recorded as 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain^[13].
Phosphodiesterase 2A, cGMP-stimulated's has part is recorded as HD/PDEase domain^[14].
Phosphodiesterase 2A, cGMP-stimulated's has part is recorded as GAF domain^[15].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as NP_001008548^[16].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as NP_001137320^[17].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as NP_001137321^[18].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as NP_001230686^[19].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as NP_001230687^[20].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as XP_006507586^[21].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as XP_006507587^[22].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as XP_006507588^[23].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as XP_006507589^[24].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as XP_006507591^[25].
Phosphodiesterase 2A, cGMP-stimulated's RefSeq protein ID is recorded as XP_006507592^[26].

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Quick Facts

Instance of protein

Part of 3'5'-cyclic nucleotide phosphodiesterase, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily, GAF-like domain superfamily, membrane protein, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family, HD/PDEase domain, protein family, GAF domain, protein family, 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

Properties

Biological process ventricular septum development, aorta development, signal transduction, coronary vasculature development, cellular response to lipopolysaccharide, positive regulation of inflammatory response, development of the heart, cardiac septum development, positive regulation of gene expression, negative regulation of transcription by RNA polymerase II, positive regulation of vascular permeability, negative regulation of vascular permeability, cellular response to cGMP, cellular response to macrophage colony-stimulating factor stimulus, cellular response to mechanical stimulus, heart valve development, cAMP catabolic process, cGMP catabolic process, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cGMP-mediated signaling, cAMP-mediated signaling, negative regulation of oxidative phosphorylation, negative regulation of cAMP-mediated signaling, cellular response to cAMP, cellular response to 2,3,7,8-tetrachlorodibenzodioxine, regulation of mitochondrion organization, negative regulation of cell death, establishment of endothelial barrier, cAMP catabolic process, regulation of nitric oxide mediated signal transduction, negative regulation of cGMP-mediated signaling, cAMP-mediated signaling, cGMP-mediated signaling, negative regulation of cAMP-mediated signaling, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cGMP catabolic process, positive regulation of gene expression, negative regulation of cGMP-mediated signaling, regulation of mitochondrion organization, cAMP-mediated signaling, cGMP-mediated signaling, negative regulation of cAMP-mediated signaling, cGMP catabolic process

Cell component Golgi apparatus, axon, presynaptic membrane, membrane, dendrite, endoplasmic reticulum, cytosol, perinuclear region of cytoplasm, nucleus, mitochondrion, mitochondrial outer membrane, mitochondrial inner membrane, cytoplasm, plasma membrane, mitochondrial matrix, membrane raft, hippocampal mossy fiber, synaptic membrane, nucleus, mitochondrial matrix, plasma membrane, perinuclear region of cytoplasm, nucleus, mitochondrial outer membrane, mitochondrial inner membrane, mitochondrial matrix, cytosol, plasma membrane, perinuclear region of cytoplasm

Encoded by Pde2a

Found in taxon house mouse

Has part(s) 3'5'-cyclic nucleotide phosphodiesterase, conserved site, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, HD/PDEase domain, GAF domain

Imported from wholeness_audit_2026-05-02

Molecular function metal ion binding, nucleotide binding, 3',5'-cyclic-nucleotide phosphodiesterase activity, hydrolase activity, TPR domain binding, phosphoric diester hydrolase activity, GAF domain binding, cyclic-nucleotide phosphodiesterase activity, protein homodimerization activity, cAMP binding, cGMP binding, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity, identical protein binding, cyclic-nucleotide phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activity, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity, cAMP binding, cGMP binding, protein homodimerization activity, 3',5'-cyclic-GMP phosphodiesterase activity, magnesium ion binding, zinc ion binding, phosphate ion binding

External References (4)

Ensembl protein id ENSMUSP00000147553, ENSMUSP00000127521, ENSMUSP00000148212, ENSMUSP00000131553, ENSMUSP00000081956, ENSMUSP00000147884, ENSMUSP00000147847

Pdb structure id 1MC0

Refseq protein id NP_001008548, NP_001137320, NP_001137321, NP_001230686, NP_001230687, XP_006507586, XP_006507587, XP_006507588, XP_006507589, XP_006507591, XP_006507592, XP_011240020, XP_030098167, XP_036008744, XP_036008745, XP_036008746

Uniprot protein id Q922S4

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Phosphodiesterase 2A, cGMP-stimulated — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Phosphodiesterase 2A, cGMP-stimulated — UniProt protein ID (P352): Q922S4. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Phosphodiesterase 2A, cGMP-stimulated — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Phosphodiesterase 2A, cGMP-stimulated — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Phosphodiesterase 2A, cGMP-stimulated — part of (P361): GAF-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Phosphodiesterase 2A, cGMP-stimulated — part of (P361): membrane protein. wikidata.org.
[8] ↑ Phosphodiesterase 2A, cGMP-stimulated — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family. wikidata.org.
[9] ↑ Phosphodiesterase 2A, cGMP-stimulated — part of (P361): HD/PDEase domain, protein family. wikidata.org.
[10] ↑ Phosphodiesterase 2A, cGMP-stimulated — part of (P361): GAF domain, protein family. wikidata.org.
[11] ↑ Phosphodiesterase 2A, cGMP-stimulated — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family. wikidata.org.
[12] ↑ Phosphodiesterase 2A, cGMP-stimulated — has part(s) (P527): 3'5'-cyclic nucleotide phosphodiesterase, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Phosphodiesterase 2A, cGMP-stimulated — has part(s) (P527): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Phosphodiesterase 2A, cGMP-stimulated — has part(s) (P527): HD/PDEase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Phosphodiesterase 2A, cGMP-stimulated — has part(s) (P527): GAF domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): NP_001008548. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): NP_001137320. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): NP_001137321. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): NP_001230686. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): NP_001230687. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): XP_006507586. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): XP_006507587. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): XP_006507588. Q20641742. Retrieved 2022-03-20. wikidata.org.
[24] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): XP_006507589. Q20641742. Retrieved 2022-03-20. wikidata.org.
[25] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): XP_006507591. Q20641742. Retrieved 2022-03-20. wikidata.org.
[26] ↑ Phosphodiesterase 2A, cGMP-stimulated — RefSeq protein ID (P637): XP_006507592. Q20641742. Retrieved 2022-03-20. wikidata.org.

Class ancestry

[1] ↑ Phosphodiesterase 2A, cGMP-stimulated is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Phosphodiesterase 2A, cGMP-stimulated. Retrieved May 3, 2026, from https://4ort.xyz/entity/phosphodiesterase-2a-cgmp-stimulated

MLA

“Phosphodiesterase 2A, cGMP-stimulated.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/phosphodiesterase-2a-cgmp-stimulated.

BibTeX

@misc{4ortxyz_phosphodiesterase-2a-cgmp-stimulated_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Phosphodiesterase 2A, cGMP-stimulated}}, year = {2026}, url = {https://4ort.xyz/entity/phosphodiesterase-2a-cgmp-stimulated}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Phosphodiesterase 2A, cGMP-stimulated — https://4ort.xyz/entity/phosphodiesterase-2a-cgmp-stimulated (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/phosphodiesterase-2a-cgmp-stimulated · Last refreshed: May 3, 2026