Phosphodiesterase 10A

mammalian protein found in Homo sapiens

Protein protein Q21119706

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Phosphodiesterase 10A

Summary

Phosphodiesterase 10A is a protein^[1].

Key Facts

Phosphodiesterase 10A's instance of is recorded as protein^[2].
Phosphodiesterase 10A's physically interacts with is recorded as ibudilast^[3].
Phosphodiesterase 10A is part of 3'5'-cyclic nucleotide phosphodiesterase^[4].
Phosphodiesterase 10A is part of 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily^[5].
Phosphodiesterase 10A is part of GAF-like domain superfamily^[6].
Phosphodiesterase 10A is part of 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family^[7].
Phosphodiesterase 10A is part of HD/PDEase domain, protein family^[8].
Phosphodiesterase 10A is part of GAF domain, protein family^[9].
Phosphodiesterase 10A is part of 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family^[10].
Phosphodiesterase 10A comprises 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain^[11].
Phosphodiesterase 10A comprises HD/PDEase domain^[12].
Phosphodiesterase 10A comprises GAF domain^[13].
Phosphodiesterase 10A comprises 3'5'-cyclic nucleotide phosphodiesterase, conserved site^[14].

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Quick Facts

Instance of protein

Part of 3'5'-cyclic nucleotide phosphodiesterase, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily, GAF-like domain superfamily, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family, HD/PDEase domain, protein family, GAF domain, protein family, 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

Properties

Biological process cAMP catabolic process, regulation of protein kinase A signaling, cGMP catabolic process, regulation of cAMP-mediated signaling, metabolism, signal transduction, G protein-coupled receptor signaling pathway, negative regulation of cGMP-mediated signaling, negative regulation of cAMP-mediated signaling, negative regulation of cGMP-mediated signaling

Cell component cytoplasm, cytosol, perikaryon, membrane, soma

Ec enzyme number 3.1.4.17

Encoded by PDE10A

Found in taxon Homo sapiens

Has part(s) 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, HD/PDEase domain, GAF domain, 3'5'-cyclic nucleotide phosphodiesterase, conserved site

Molecular function nucleotide binding, 3',5'-cyclic-nucleotide phosphodiesterase activity, cAMP binding, cGMP binding, metal ion binding, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity, cyclic-nucleotide phosphodiesterase activity, catalytic activity, phosphoric diester hydrolase activity, hydrolase activity, 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity, cAMP binding, 3',5'-cyclic-GMP phosphodiesterase activity

Physically interacts with ibudilast

External References (4)

Ensembl protein id ENSP00000355847, ENSP00000438284, ENSP00000478556

Pdb structure id 2OUN, 2OUP, 2OUQ, 2OUR, 2OUS, 2OUU, 2OUV, 2OUY, 2WEY, 2Y0J, 2ZMF, 3SN7, 3SNI, 3SNL, 3UI7, 3UUO, 3WI2, 3WS8, 3WS9, 3WYK, 3WYL, 3WYM, 4AEL, 4AJD, 4AJF, 4AJG, 4AJM, 4BBX, 4DDL, 4DFF, 4FCB, 4FCD, 4HEU, 4HF4, 4LKQ, 4LLJ, 4LLK, 4LLP, 4LLX, 4LM0, 4LM1, 4LM2, 4LM3, 4LM4, 4MRW, 4MRZ, 4MS0, 4MSA, 4MSC, 4MSE, 4MSH, 4MSN, 4MUW, 4MVH, 4P0N, 4P1R, 4PHW, 4TPM, 4TPP, 4WN1, 4XY2, 4YQH, 4YS7, 4ZO5, 5C1W, 5C28, 5C29, 5C2A, 5C2H, 5DH5, 5AXQ, 5DH4, 5AXP, 5C2E, 5EDH, 5EDI, 5EDG, 5EDE, 5I2R, 5B4L, 5B4K

Refseq protein id NP_001124162, NP_006652, XP_006715384, XP_011533689, XP_011533690, XP_011533695, XP_016865683, XP_016865684, XP_016865685, XP_016865686, XP_024302079, XP_024302080

Uniprot protein id Q9Y233

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Phosphodiesterase 10A — instance of (P31): protein. Q905695. Retrieved 2018-07-18. wikidata.org.
[3] ↑ Phosphodiesterase 10A — physically interacts with (P129): ibudilast. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[4] ↑ Phosphodiesterase 10A — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Phosphodiesterase 10A — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Phosphodiesterase 10A — part of (P361): GAF-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Phosphodiesterase 10A — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family. wikidata.org.
[8] ↑ Phosphodiesterase 10A — part of (P361): HD/PDEase domain, protein family. wikidata.org.
[9] ↑ Phosphodiesterase 10A — part of (P361): GAF domain, protein family. wikidata.org.
[10] ↑ Phosphodiesterase 10A — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family. wikidata.org.
[11] ↑ Phosphodiesterase 10A — has part(s) (P527): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Phosphodiesterase 10A — has part(s) (P527): HD/PDEase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Phosphodiesterase 10A — has part(s) (P527): GAF domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Phosphodiesterase 10A — has part(s) (P527): 3'5'-cyclic nucleotide phosphodiesterase, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Phosphodiesterase 10A is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Phosphodiesterase 10A. Retrieved May 3, 2026, from https://4ort.xyz/entity/phosphodiesterase-10a-q21119706

MLA

“Phosphodiesterase 10A.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/phosphodiesterase-10a-q21119706.

BibTeX

@misc{4ortxyz_phosphodiesterase-10a-q21119706_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Phosphodiesterase 10A}}, year = {2026}, url = {https://4ort.xyz/entity/phosphodiesterase-10a-q21119706}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Phosphodiesterase 10A — https://4ort.xyz/entity/phosphodiesterase-10a-q21119706 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/phosphodiesterase-10a-q21119706 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → PDE10A

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → nucleotide binding, 3',5'-cyclic-nucleotide phosphodiesterase activity, cAMP binding +13

+ 12 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 3.1.4.17, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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