peroxisomal biogenesis factor 2

mammalian protein found in Homo sapiens
Protein protein Q21122491

Facts

9 properties
Instance of
protein
Part of
Zinc finger, RING/FYVE/PHD-type, Peroxisomal Protein Importer, Zinc finger, RING-type, protein family, Zinc finger, C3HC4 RING-type, protein family, Pex, N-terminal domain, protein family, Zinc finger, RING-type, conserved site, protein family[1][2][3][4][5][6]
Biological process
negative regulation of fibroblast proliferation, protein import into peroxisome matrix, fatty acid beta-oxidation, protein destabilization, very long-chain fatty acid metabolic process, negative regulation of transcription by RNA polymerase II, peroxisome organization, negative regulation of epithelial cell proliferation, protein ubiquitination, protein targeting to peroxisome[22][23][24][25][26][27][28][29][30][31]
Cell component
Cdc73/Paf1 complex, peroxisome, integral component of peroxisomal membrane, integral component of membrane, membrane, peroxisomal membrane, peroxisomal membrane, membrane[16][17][18][19][20][21]
EC enzyme number
2.3.2.27, 2.3.2.36[11][12]
Encoded by
PEX2[32]
Found in taxon
Homo sapiens[33]
Has part(s)
Zinc finger, RING-type, conserved site, Zinc finger, RING-type, Zinc finger, C3HC4 RING-type, Pex, N-terminal[7][8][9][10]
Molecular function
protein binding, metal ion binding, ubiquitin protein ligase activity[13][14][15]
🏷️ Also known as
en 35 kDa peroxisomal membrane protein en PAF-1 en Peroxin-2 en peroxisomal biogenesis factor 2 en Peroxisomal membrane protein 3 en peroxisomal membrane protein 3, 35kDa en peroxisome assembly factor 1 en peroxisome biogenesis factor 2 en PEX2 en RING finger protein 72
🔖 Identifiers · 7
MeSH descriptor ID
D000074428
Transporter Classification Database ID
3.A.20.1.1
UMLS CUI
C0286995
UniProt protein ID
P28328

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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [2] ↑ . Retrieved . wikidata.org.
  3. [3] ↑ . wikidata.org.
  4. [4] ↑ . wikidata.org.
  5. [5] ↑ . wikidata.org.
  6. [6] ↑ . wikidata.org.
  7. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [11] ↑ . UniProt. Retrieved . wikidata.org.
  12. [12] ↑ . UniProt. Retrieved . wikidata.org.
  13. [13] ↑ . Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . Cysteine Ubiquitination of PTS1 Receptor Pex5p Regulates Pex5p Recycling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . The peroxisomal membrane targeting elements of human peroxin 2 (PEX2). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . Defective PEX gene products correlate with the protein import, biochemical abnormalities, and phenotypic heterogeneity in peroxisome biogenesis disorders. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . Defective PEX gene products correlate with the protein import, biochemical abnormalities, and phenotypic heterogeneity in peroxisome biogenesis disorders. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . Restoration of PEX2 peroxisome assembly defects by overexpression of PMP70. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . A human gene responsible for Zellweger syndrome that affects peroxisome assembly. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [29] ↑ . The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [32] ↑ . UniProt. Retrieved . wikidata.org.
  33. [33] ↑ . UniProt. Retrieved . wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). peroxisomal biogenesis factor 2. Retrieved October 30, 2026, from https://4ort.xyz/entity/peroxisomal-biogenesis-factor-2
MLA “peroxisomal biogenesis factor 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 30 Oct. 2026, https://4ort.xyz/entity/peroxisomal-biogenesis-factor-2.
BibTeX @misc{4ortxyz_peroxisomal-biogenesis-factor-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{peroxisomal biogenesis factor 2}}, year = {2026}, url = {https://4ort.xyz/entity/peroxisomal-biogenesis-factor-2}, note = {Accessed: 2026-10-30}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 15w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon → Homo sapiens
    MeSH tree code → D12.776.157.635.500, D12.776.543.689
    Wikidata description → mammalian protein found in Homo sapiens
    RefSeq protein ID → NP_000309, NP_001073336, NP_001165557 +1
    + 14 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ EC enzyme number: 2.3.2.27, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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