Parkinsonism associated deglycase

mammalian protein found in Homo sapiens

Protein protein Q21097342

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Parkinsonism associated deglycase

Summary

Parkinsonism associated deglycase is a protein^[1].

Key Facts

Parkinsonism associated deglycase's instance of is recorded as protein^[2].
Parkinsonism associated deglycase is part of Protein/nucleic acid deglycase DJ-1^[3].
Parkinsonism associated deglycase is part of Class I glutamine amidotransferase-like^[4].
Parkinsonism associated deglycase is part of DJ-1/PfpI domain, protein family^[5].
Parkinsonism associated deglycase comprises DJ-1/PfpI^[6].
Parkinsonism associated deglycase's molecular function is recorded as signaling receptor binding^[7].
Parkinsonism associated deglycase's molecular function is recorded as cytokine binding^[8].
Parkinsonism associated deglycase's molecular function is recorded as cupric ion binding^[9].
Parkinsonism associated deglycase's molecular function is recorded as transcription factor binding^[10].
Parkinsonism associated deglycase's molecular function is recorded as L-dopa decarboxylase activator activity^[11].
Parkinsonism associated deglycase's molecular function is recorded as peptidase activity^[12].
Parkinsonism associated deglycase's molecular function is recorded as kinase binding^[13].
Parkinsonism associated deglycase's molecular function is recorded as tyrosine 3-monooxygenase activator activity^[14].
Parkinsonism associated deglycase's molecular function is recorded as enzyme binding^[15].
Parkinsonism associated deglycase's molecular function is recorded as mRNA binding^[16].
Parkinsonism associated deglycase's molecular function is recorded as protein homodimerization activity^[17].
Parkinsonism associated deglycase's molecular function is recorded as scaffold protein binding^[18].
Parkinsonism associated deglycase's molecular function is recorded as small protein activating enzyme binding^[19].
Parkinsonism associated deglycase's molecular function is recorded as single-stranded DNA binding^[20].
Parkinsonism associated deglycase's molecular function is recorded as ubiquitin-like protein conjugating enzyme binding^[21].
Parkinsonism associated deglycase's molecular function is recorded as protein binding^[22].
Parkinsonism associated deglycase's molecular function is recorded as peroxiredoxin activity^[23].
Parkinsonism associated deglycase's molecular function is recorded as double-stranded DNA binding^[24].
Parkinsonism associated deglycase's molecular function is recorded as copper ion binding^[25].
Parkinsonism associated deglycase's molecular function is recorded as mercury ion binding^[26].

⭐ Popularity Graph

1/100 established

Quick Facts

Instance of protein

Part of Protein/nucleic acid deglycase DJ-1, Class I glutamine amidotransferase-like, DJ-1/PfpI domain, protein family

Properties

Biological process negative regulation of neuron apoptotic process, positive regulation of transcription regulatory region DNA binding, negative regulation of protein sumoylation, negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, negative regulation of protein binding, synaptic transmission, dopaminergic, positive regulation of interleukin-8 production, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, Ras protein signal transduction, cellular response to glyoxal, negative regulation of protein acetylation, positive regulation of reactive oxygen species biosynthetic process, positive regulation of oxidative phosphorylation uncoupler activity, positive regulation of protein kinase B signaling, negative regulation of protein catabolic process, adult locomotory behavior, regulation of neuron apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of cell death, glycolate biosynthetic process, positive regulation of protein homodimerization activity, negative regulation of gene expression, single fertilization, positive regulation of peptidyl-serine phosphorylation, positive regulation of mitochondrial electron transport, NADH to ubiquinone, negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway, negative regulation of oxidative stress-induced cell death, inflammatory response, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, regulation of supramolecular fiber organization, negative regulation of neuron death, negative regulation of protein phosphorylation, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of protein kinase activity, negative regulation of oxidative stress-induced neuron death, membrane depolarization, protein stabilization, mitochondrion organization, positive regulation of DNA-binding transcription factor activity, negative regulation of death-inducing signaling complex assembly, negative regulation of apoptotic process, proteolysis, negative regulation of protein K48-linked deubiquitination, dopamine uptake involved in synaptic transmission, positive regulation of tyrosine 3-monooxygenase activity, positive regulation of L-dopa decarboxylase activity, negative regulation of hydrogen peroxide-induced neuron death, regulation of inflammatory response, regulation of androgen receptor signaling pathway, negative regulation of hydrogen peroxide-induced cell death, positive regulation of autophagy of mitochondrion, response to hydrogen peroxide, detoxification of copper ion, positive regulation of superoxide dismutase activity, positive regulation of dopamine biosynthetic process, positive regulation of protein localization to nucleus, positive regulation of L-dopa biosynthetic process, activation of protein kinase B activity, membrane hyperpolarization, detoxification of mercury ion, negative regulation of TRAIL-activated apoptotic signaling pathway, cellular oxidant detoxification, negative regulation of ubiquitin-specific protease activity, autophagy, cellular response to reactive oxygen species, regulation of mitochondrial membrane potential, negative regulation of protein ubiquitination, hydrogen peroxide metabolic process, positive regulation of gene expression, negative regulation of protein export from nucleus, negative regulation of ubiquitin-protein transferase activity, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, cellular response to oxidative stress, positive regulation of androgen receptor activity, positive regulation of pyrroline-5-carboxylate reductase activity, positive regulation of transcription by RNA polymerase II, cellular response to hydrogen peroxide, methylglyoxal metabolic process, lactate biosynthetic process, peptidyl-cysteine deglycation, peptidyl-arginine deglycation, peptidyl-lysine deglycation, protein deglycation, glyoxal removal, protein deglycation, methylglyoxal removal, glutathione deglycation, glyoxal metabolic process, negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway, positive regulation of acute inflammatory response to antigenic stimulus, protein deglycosylation, positive regulation of NAD(P)H oxidase activity, DNA repair, cellular response to DNA damage stimulus, insulin secretion, glucose homeostasis, guanine deglycation, guanine deglycation, methylglyoxal removal, guanine deglycation, glyoxal removal, negative regulation of reactive oxygen species biosynthetic process, protein deglycation, glyoxal removal, guanine deglycation, glyoxal removal

Cell component cytoplasm, cytosol, membrane, mitochondrial intermembrane space, mitochondrion, neuron projection, nucleus, mitochondrial respiratory chain complex I, endoplasmic reticulum, membrane raft, chromatin, extracellular exosome, plasma membrane, mitochondrial matrix, cell body, PML body, presynapse, perinuclear region of cytoplasm, axon, nucleus, nucleoplasm, cytosol, extracellular exosome

Ec enzyme number 3.5.1.124

Encoded by PARK7

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) DJ-1/PfpI

Molecular function signaling receptor binding, cytokine binding, cupric ion binding, transcription factor binding, L-dopa decarboxylase activator activity, peptidase activity, kinase binding, tyrosine 3-monooxygenase activator activity, enzyme binding, mRNA binding, protein homodimerization activity, scaffold protein binding, small protein activating enzyme binding, single-stranded DNA binding, ubiquitin-like protein conjugating enzyme binding, protein binding, peroxiredoxin activity, double-stranded DNA binding, copper ion binding, mercury ion binding, transcription coactivator activity, oxidoreductase activity, acting on peroxide as acceptor, androgen receptor binding, superoxide dismutase copper chaperone activity, RNA binding, identical protein binding, ubiquitin-specific protease binding, hydrolase activity, cuprous ion binding, cadherin binding, protein deglycase activity, protein deglycase activity, cadherin binding, protein-containing complex binding

External References (7)

Ensembl protein id ENSP00000340278, ENSP00000366708, ENSP00000366711, ENSP00000418770, ENSP00000465404, ENSP00000466242, ENSP00000466756

Mesh descriptor id D000071617

Mesh tree code D08.811.277.785, D12.776.705.875

Pdb structure id 1J42, 1P5F, 1PDV, 1PDW, 1PE0, 1Q2U, 1SOA, 1UCF, 2OR3, 2R1T, 2R1U, 2R1V, 2RK3, 2RK4, 2RK6, 3B36, 3B38, 3B3A, 3BWE, 3CY6, 3CYF, 3CZ9, 3CZA, 3EZG, 3F71, 3SF8, 4BTE, 4MNT, 4MTC, 4N0M, 4N12, 4OGF, 4OQ4, 4P2G, 4P34, 4P35, 4P36, 4ZGG, 4RKW, 4RKY, 4S0Z

Refseq protein id NP_001116849, NP_009193, XP_005263481

Umls cui C4255233

Uniprot protein id Johanna Herzogenberg

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Parkinsonism associated deglycase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Parkinsonism associated deglycase — part of (P361): Protein/nucleic acid deglycase DJ-1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ Parkinsonism associated deglycase — part of (P361): Class I glutamine amidotransferase-like. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Parkinsonism associated deglycase — part of (P361): DJ-1/PfpI domain, protein family. wikidata.org.
[6] ↑ Parkinsonism associated deglycase — has part(s) (P527): DJ-1/PfpI. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Parkinsonism associated deglycase — molecular function (P680): signaling receptor binding. DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Parkinsonism associated deglycase — molecular function (P680): cytokine binding. DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Parkinsonism associated deglycase — molecular function (P680): cupric ion binding. DJ-1 is a copper chaperone acting on SOD1 activation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Parkinsonism associated deglycase — molecular function (P680): transcription factor binding. DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Parkinsonism associated deglycase — molecular function (P680): L-dopa decarboxylase activator activity. Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Parkinsonism associated deglycase — molecular function (P680): peptidase activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Parkinsonism associated deglycase — molecular function (P680): kinase binding. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Parkinsonism associated deglycase — molecular function (P680): tyrosine 3-monooxygenase activator activity. Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Parkinsonism associated deglycase — molecular function (P680): enzyme binding. DJ-1 binds to mitochondrial complex I and maintains its activity. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Parkinsonism associated deglycase — molecular function (P680): mRNA binding. RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Parkinsonism associated deglycase — molecular function (P680): protein homodimerization activity. Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Parkinsonism associated deglycase — molecular function (P680): scaffold protein binding. DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Parkinsonism associated deglycase — molecular function (P680): small protein activating enzyme binding. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Parkinsonism associated deglycase — molecular function (P680): single-stranded DNA binding. Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Parkinsonism associated deglycase — molecular function (P680): ubiquitin-like protein conjugating enzyme binding. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Parkinsonism associated deglycase — molecular function (P680): protein binding. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Parkinsonism associated deglycase — molecular function (P680): peroxiredoxin activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Parkinsonism associated deglycase — molecular function (P680): double-stranded DNA binding. Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Parkinsonism associated deglycase — molecular function (P680): copper ion binding. Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Parkinsonism associated deglycase — molecular function (P680): mercury ion binding. Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Parkinsonism associated deglycase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Parkinsonism associated deglycase. Retrieved May 3, 2026, from https://4ort.xyz/entity/parkinsonism-associated-deglycase

MLA

“Parkinsonism associated deglycase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/parkinsonism-associated-deglycase.

BibTeX

@misc{4ortxyz_parkinsonism-associated-deglycase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Parkinsonism associated deglycase}}, year = {2026}, url = {https://4ort.xyz/entity/parkinsonism-associated-deglycase}, note = {Accessed: 2026-05-03}}

LLM prompt

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Canonical URL: https://4ort.xyz/entity/parkinsonism-associated-deglycase · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

17d ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Found in taxon → Homo sapiens

Mesh tree code → D08.811.277.785, D12.776.705.875

Wikidata description → mammalian protein found in Homo sapiens

Pdb structure id → 1J42, 1P5F, 1PDV +38

+ 15 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 3.5.1.124, [[:toollabs:quickstatements/#/batch/261488|batch #261488]]"

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