Parkin RBR E3 ubiquitin protein ligase

mammalian protein found in Homo sapiens

Protein protein Q2472777

Press Enter · cited answer in seconds

Parkin RBR E3 ubiquitin protein ligase

Summary

Parkin RBR E3 ubiquitin protein ligase is a protein^[1]. It is known by 8 alternative names across languages and contexts.^[2]

Key Facts

Parkin RBR E3 ubiquitin protein ligase's instance of is recorded as protein^[3].
Parkin RBR E3 ubiquitin protein ligase is part of Ubiquitin-like domain superfamily^[4].
Parkin RBR E3 ubiquitin protein ligase is part of E3 ubiquitin-protein ligase parkin^[5].
Parkin RBR E3 ubiquitin protein ligase is part of IBR domain, protein family^[6].
Parkin RBR E3 ubiquitin protein ligase is part of Ubiquitin-like domain, protein family^[7].
Parkin RBR E3 ubiquitin protein ligase comprises Ubiquitin domain^[8].
Parkin RBR E3 ubiquitin protein ligase comprises IBR domain^[9].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as phospholipase binding^[10].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as DNA-binding transcription factor activity^[11].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as SH3 domain binding^[12].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as histone deacetylase binding^[13].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as tubulin binding^[14].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as cullin family protein binding^[15].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as PDZ domain binding^[16].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as heat shock protein binding^[17].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as metal ion binding^[18].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as Hsp70 protein binding^[19].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as kinase binding^[20].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as enzyme binding^[21].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as beta-catenin binding^[22].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as zinc ion binding^[23].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as protein binding^[24].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as ubiquitin conjugating enzyme binding^[25].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as protein kinase binding^[26].
Parkin RBR E3 ubiquitin protein ligase's molecular function is recorded as chaperone binding^[27].

Why It Matters

Parkin RBR E3 ubiquitin protein ligase is known by 8 alternative names across languages and contexts.^[2]

⭐ Popularity Graph

2/100 established

🌐 Wiki Languages

7 / 423 langs

📈 Wikipedia Views · last 62h

110/mo 201/yr

Quick Facts

Instance of protein

Part of Ubiquitin-like domain superfamily, E3 ubiquitin-protein ligase parkin, IBR domain, protein family, Ubiquitin-like domain, protein family

Properties

Biological process negative regulation of neuron apoptotic process, protein K29-linked ubiquitination, negative regulation of insulin secretion, ERAD pathway, positive regulation of mitochondrial fission, positive regulation of mitophagy in response to mitochondrial depolarization, positive regulation of protein catabolic process, synaptic transmission, glutamatergic, positive regulation of tumor necrosis factor-mediated signaling pathway, neuron cellular homeostasis, regulation of protein ubiquitination, cellular response to toxic substance, modulation of chemical synaptic transmission, regulation of synaptic vesicle transport, learning, protein monoubiquitination, synaptic transmission, dopaminergic, positive regulation of neurotransmitter uptake, regulation of glucose metabolic process, protein K6-linked ubiquitination, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of spontaneous neurotransmitter secretion, negative regulation by host of viral genome replication, positive regulation of DNA binding, macroautophagy, negative regulation of canonical Wnt signaling pathway, Unfolded Protein Response, aggresome assembly, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of dopamine secretion, zinc ion homeostasis, free ubiquitin chain polymerization, regulation of transcription, DNA-templated, locomotory behavior, norepinephrine metabolic process, negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, adult locomotory behavior, protein metabolic process, negative regulation of cell death, response to oxidative stress, protein K27-linked ubiquitination, negative regulation of gene expression, transcription, DNA-templated, response to endoplasmic reticulum stress, protein K11-linked ubiquitination, central nervous system development, negative regulation of oxidative stress-induced cell death, positive regulation of mitochondrial fusion, protein localization to mitochondrion, proteasomal protein catabolic process, cellular response to manganese ion, negative regulation of mitochondrial fusion, protein autoubiquitination, negative regulation of neuron death, negative regulation of protein phosphorylation, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of primary amine oxidase activity, startle response, mitochondrial fission, regulation of mitochondrion organization, regulation of canonical Wnt signaling pathway, negative regulation of release of cytochrome c from mitochondria, protein stabilization, mitochondrion organization, protein polyubiquitination, negative regulation of transcription by RNA polymerase II, regulation of reactive oxygen species metabolic process, regulation of neurotransmitter secretion, positive regulation of protein linear polyubiquitination, protein K48-linked ubiquitination, dopamine uptake involved in synaptic transmission, regulation of autophagy, regulation of protein targeting to mitochondrion, protein destabilization, negative regulation of glucokinase activity, positive regulation of proteasomal protein catabolic process, protein K63-linked ubiquitination, cellular response to dopamine, regulation of lipid transport, negative regulation of actin filament bundle assembly, regulation of dopamine metabolic process, regulation of mitochondrial membrane potential, autophagy, negative regulation of JNK cascade, dopamine metabolic process, positive regulation of gene expression, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of dendrite extension, negative regulation of reactive oxygen species metabolic process, positive regulation of transcription by RNA polymerase II, mitophagy, protein ubiquitination, parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein deubiquitination, regulation of protein stability, positive regulation of protein binding, mitochondrion to lysosome transport, regulation of cellular response to oxidative stress, negative regulation of exosomal secretion, positive regulation of retrograde transport, endosome to Golgi, negative regulation of intralumenal vesicle formation, positive regulation of protein localization to membrane, autophagy of mitochondrion, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, positive regulation of autophagy of mitochondrion, ubiquitin-dependent protein catabolic process, protein polyubiquitination, autophagy of mitochondrion, negative regulation of protein phosphorylation, ubiquitin-dependent protein catabolic process, regulation of mitochondrion organization, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of cellular response to oxidative stress, regulation of apoptotic process

Cell component cytoplasm, cytosol, mitochondrion, perinuclear region of cytoplasm, nucleus, Lewy body, SCF ubiquitin ligase complex, aggresome, endoplasmic reticulum, Golgi apparatus, Parkin-FBXW7-Cul1 ubiquitin ligase complex, ubiquitin ligase complex, LUBAC complex, presynapse, neuron projection, mitochondrion-derived vesicle, nuclear speck, protein-containing complex, ubiquitin ligase complex, cytoplasm, mitochondrion, endoplasmic reticulum, Golgi apparatus, cytosol

Ec enzyme number 2.3.2.31

Encoded by PRKN

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Has part(s) Ubiquitin domain, IBR domain

Molecular function phospholipase binding, DNA-binding transcription factor activity, SH3 domain binding, histone deacetylase binding, tubulin binding, cullin family protein binding, PDZ domain binding, heat shock protein binding, metal ion binding, Hsp70 protein binding, kinase binding, enzyme binding, beta-catenin binding, zinc ion binding, protein binding, ubiquitin conjugating enzyme binding, protein kinase binding, chaperone binding, transcription cis-regulatory region binding, ubiquitin-protein transferase activity, F-box domain binding, ubiquitin binding, identical protein binding, actin binding, ubiquitin-specific protease binding, G protein-coupled receptor binding, ubiquitin protein ligase binding, transferase activity, ubiquitin protein ligase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, protein-containing complex binding

External References (7)

Ensembl protein id ENSP00000343589, ENSP00000355860, ENSP00000355862, ENSP00000355863, ENSP00000355865, ENSP00000434414, ENSP00000355858, ENSP00000478353, ENSP00000480716, ENSP00000483773, ENSP00000484112, ENSP00000501207

Freebase id /m/03r3tb

Microsoft academic id (discontinued) 2777668072

Openalex id C2777668072

Pdb structure id 1IYF, 2JMO, 4I1F, 4I1H, 4BM9, 5C1Z, 5C23, 5C9V

Refseq protein id NP_004553, NP_054642, NP_054643, XP_011534165, XP_016866397, XP_016866398, XP_024302217

Uniprot protein id O60260

🌐 Available in 4 languages

enParkin (protein) deUbiquitin-Protein-Ligase Parkin frParkine ukПаркін (білок)

🏷️ Also known as

en E3 ubiquitin-protein ligase parkin en PARK2 en Parkinson disease (autosomal recessive, juvenile) 2, parkin en Parkinson disease protein 2 en parkinson juvenile disease protein 2 en parkinson protein 2 E3 ubiquitin protein ligase en parkinson protein 2, E3 ubiquitin protein ligase (parkin) en PRKN

🔗 Connections

Cell component 12

mitochondrion, mitochondrion, nucleus, cytoplasm, cytoplasm, endoplasmic reticulum, endoplasmic reticulum, Golgi apparatus +4 more

Biological process 7

learning, autophagy, startle response, autophagy of mitochondrion, autophagy of mitochondrion, ERAD pathway, mitochondrial fission

Found in taxon 1

Homo sapiens

Instance of 1

protein

Molecular function 1

protein binding

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Parkin RBR E3 ubiquitin protein ligase. Retrieved May 3, 2026, from https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase

MLA

“Parkin RBR E3 ubiquitin protein ligase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase.

BibTeX

@misc{4ortxyz_parkin-rbr-e3-ubiquitin-protein-ligase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Parkin RBR E3 ubiquitin protein ligase}}, year = {2026}, url = {https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Parkin RBR E3 ubiquitin protein ligase — https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Instance of → —

Part of → —

Encoded by → PRKN

Biological process → negative regulation of neuron apoptotic process, protein K29-linked ubiquitination, negative regulation of insulin secretion +112

+ 9 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.3.2.31, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"

Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.

Parkin RBR E3 ubiquitin protein ligase

Parkin RBR E3 ubiquitin protein ligase

Summary

Key Facts

Why It Matters

References

Direct Wikidata claims

Class ancestry

Aggregate / graph-position facts

📑 Cite this page

Edit History