Paired like homeodomain 2

mammalian protein found in Homo sapiens

Protein protein Q21108503

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Summary

Paired like homeodomain 2 is a protein^[1].

Key Facts

Paired like homeodomain 2's instance of is recorded as protein^[2].
Paired like homeodomain 2's UniProt protein ID is recorded as U2^[3].
Paired like homeodomain 2's part of is recorded as Homeobox-like domain superfamily^[4].
Paired like homeodomain 2's part of is recorded as Homeobox protein Pitx/unc30^[5].
Paired like homeodomain 2's part of is recorded as Homeobox domain, protein family^[6].
Paired like homeodomain 2's part of is recorded as OAR domain, protein family^[7].
Paired like homeodomain 2's part of is recorded as Homeobox, conserved site, protein family^[8].
Paired like homeodomain 2's MeSH descriptor ID is recorded as D000097577^[9].
Paired like homeodomain 2's has part is recorded as Homeobox, conserved site^[10].
Paired like homeodomain 2's has part is recorded as Homeobox domain^[11].
Paired like homeodomain 2's has part is recorded as OAR domain^[12].
Paired like homeodomain 2's RefSeq protein ID is recorded as NP_000316^[13].
Paired like homeodomain 2's RefSeq protein ID is recorded as NP_001191326^[14].
Paired like homeodomain 2's RefSeq protein ID is recorded as NP_001191327^[15].
Paired like homeodomain 2's RefSeq protein ID is recorded as NP_001191328^[16].
Paired like homeodomain 2's RefSeq protein ID is recorded as NP_700475^[17].
Paired like homeodomain 2's RefSeq protein ID is recorded as NP_700476^[18].
Paired like homeodomain 2's RefSeq protein ID is recorded as XP_024309858^[19].
Paired like homeodomain 2's PDB structure ID is recorded as 2L7F^[20].
Paired like homeodomain 2's PDB structure ID is recorded as 2L7M^[21].
Paired like homeodomain 2's PDB structure ID is recorded as 2LKX^[22].
Paired like homeodomain 2's MeSH tree code is recorded as D12.776.260.400.228^[23].
Paired like homeodomain 2's MeSH tree code is recorded as D12.776.930.320^[24].
Paired like homeodomain 2's molecular function is recorded as identical protein binding^[25].
Paired like homeodomain 2's molecular function is recorded as protein homodimerization activity^[26].

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Quick Facts

Instance of protein

Part of Homeobox-like domain superfamily, Homeobox protein Pitx/unc30, Homeobox domain, protein family, OAR domain, protein family, Homeobox, conserved site, protein family

Properties

Biological process response to vitamin A, female gonad development, vascular associated smooth muscle cell differentiation, regulation of transcription by RNA polymerase II, skeletal muscle tissue development, cell proliferation involved in outflow tract morphogenesis, prolactin secreting cell differentiation, in utero embryonic development, pituitary gland development, vasculogenesis, regulation of cell population proliferation, myoblast fusion, hair cell differentiation, spleen development, regulation of transcription, DNA-templated, transcription by RNA polymerase II, embryonic camera-type eye development, ventricular septum morphogenesis, endodermal digestive tract morphogenesis, determination of left/right symmetry, cardiac muscle tissue development, positive regulation of transcription, DNA-templated, subthalamic nucleus development, ventricular cardiac muscle cell development, left/right axis specification, hypothalamus cell migration, animal organ morphogenesis, regulation of cell migration, development of the heart, embryonic digestive tract morphogenesis, branching involved in blood vessel morphogenesis, cardiac muscle cell differentiation, digestive system development, multicellular organism development, atrioventricular valve development, pulmonary vein morphogenesis, cardiac neural crest cell migration involved in outflow tract morphogenesis, embryonic hindlimb morphogenesis, lung development, superior vena cava morphogenesis, positive regulation of DNA binding, extraocular skeletal muscle development, pulmonary myocardium development, deltoid tuberosity development, atrial cardiac muscle tissue morphogenesis, male gonad development, anatomical structure morphogenesis, brain development, neuron differentiation, odontogenesis of dentin-containing tooth, Wnt signaling pathway, left lung morphogenesis, somatotropin secreting cell differentiation, positive regulation of myoblast proliferation, camera-type eye development, response to hormone, odontogenesis, iris morphogenesis, neuron migration, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, cardiac neural crest cell migration involved in outflow tract morphogenesis, regulation of transcription by RNA polymerase II, determination of left/right symmetry, anatomical structure morphogenesis, deltoid tuberosity development, odontogenesis, positive regulation of transcription by RNA polymerase II, spleen development, cell proliferation involved in outflow tract morphogenesis, left/right axis specification

Cell component nucleus, cytoplasm, transcription regulator complex, nucleoplasm, nucleus, transcription regulator complex

Encoded by PITX2

Found in taxon Homo sapiens

Has part(s) Homeobox, conserved site, Homeobox domain, OAR domain

Imported from wholeness_audit_2026-05-02

Molecular function identical protein binding, protein homodimerization activity, transcription cis-regulatory region binding, sequence-specific DNA binding, DNA binding, transcription coactivator activity, chromatin DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, ribonucleoprotein complex binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, transcription factor binding, phosphoprotein binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (6)

Ensembl protein id ENSP00000347004, ENSP00000347192, ENSP00000481951, ENSP00000484763, ENSP00000484909, ENSP00000378095, ENSP00000421454, ENSP00000424142, ENSP00000475617, ENSP00000495061

Mesh descriptor id D000097577

Mesh tree code D12.776.260.400.228, D12.776.930.320

Pdb structure id 2L7F, 2L7M, 2LKX

Refseq protein id NP_000316, NP_001191326, NP_001191327, NP_001191328, NP_700475, NP_700476, XP_024309858

Uniprot protein id U2

🏷️ Also known as

en all1-responsive gene 1 en ALL1-responsive protein ARP1 en homeobox protein PITX2 en Paired like homeodomain 2 en paired-like homeodomain transcription factor 2 en pituitary homeobox 2 en PITX2 en RIEG bicoid-related homeobox transcription factor en rieg bicoid-related homeobox transcription factor 1 en solurshin

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Paired like homeodomain 2 — instance of (P31): protein. UniProt. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Paired like homeodomain 2 — UniProt protein ID (P352): U2. UniProt. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Paired like homeodomain 2 — part of (P361): Homeobox-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Paired like homeodomain 2 — part of (P361): Homeobox protein Pitx/unc30. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Paired like homeodomain 2 — part of (P361): Homeobox domain, protein family. wikidata.org.
[7] ↑ Paired like homeodomain 2 — part of (P361): OAR domain, protein family. wikidata.org.
[8] ↑ Paired like homeodomain 2 — part of (P361): Homeobox, conserved site, protein family. wikidata.org.
[9] ↑ Paired like homeodomain 2 — MeSH descriptor ID (P486): D000097577. wikidata.org.
[10] ↑ Paired like homeodomain 2 — has part(s) (P527): Homeobox, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Paired like homeodomain 2 — has part(s) (P527): Homeobox domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Paired like homeodomain 2 — has part(s) (P527): OAR domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Paired like homeodomain 2 — RefSeq protein ID (P637): NP_000316. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Paired like homeodomain 2 — RefSeq protein ID (P637): NP_001191326. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ Paired like homeodomain 2 — RefSeq protein ID (P637): NP_001191327. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ Paired like homeodomain 2 — RefSeq protein ID (P637): NP_001191328. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ Paired like homeodomain 2 — RefSeq protein ID (P637): NP_700475. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ Paired like homeodomain 2 — RefSeq protein ID (P637): NP_700476. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ Paired like homeodomain 2 — RefSeq protein ID (P637): XP_024309858. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ Paired like homeodomain 2 — PDB structure ID (P638): 2L7F. UniProt. Retrieved 2016-08-05. wikidata.org.
[21] ↑ Paired like homeodomain 2 — PDB structure ID (P638): 2L7M. UniProt. Retrieved 2016-08-05. wikidata.org.
[22] ↑ Paired like homeodomain 2 — PDB structure ID (P638): 2LKX. UniProt. Retrieved 2016-08-05. wikidata.org.
[23] ↑ Paired like homeodomain 2 — MeSH tree code (P672): D12.776.260.400.228. wikidata.org.
[24] ↑ Paired like homeodomain 2 — MeSH tree code (P672): D12.776.930.320. wikidata.org.
[25] ↑ Paired like homeodomain 2 — molecular function (P680): identical protein binding. Dominant negative dimerization of a mutant homeodomain protein in Axenfeld-Rieger syndrome. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Paired like homeodomain 2 — molecular function (P680): protein homodimerization activity. Proteomic and genomic analysis of PITX2 interacting and regulating networks. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Paired like homeodomain 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Paired like homeodomain 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/paired-like-homeodomain-2

MLA

“Paired like homeodomain 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/paired-like-homeodomain-2.

BibTeX

@misc{4ortxyz_paired-like-homeodomain-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Paired like homeodomain 2}}, year = {2026}, url = {https://4ort.xyz/entity/paired-like-homeodomain-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Paired like homeodomain 2 — https://4ort.xyz/entity/paired-like-homeodomain-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/paired-like-homeodomain-2 · Last refreshed: May 3, 2026