Paired box 6

mammalian protein found in Mus musculus

Protein protein Q14916221

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Paired box 6

Summary

Paired box 6 is a protein^[1].

Key Facts

Paired box 6's instance of is recorded as protein^[2].
Paired box 6's subclass of is recorded as protein^[3].
Paired box 6's UniProt protein ID is recorded as P63015^[4].
Paired box 6's part of is recorded as Homeobox-like domain superfamily^[5].
Paired box 6's part of is recorded as Winged helix-like DNA-binding domain superfamily^[6].
Paired box 6's part of is recorded as Homeobox domain, protein family^[7].
Paired box 6's part of is recorded as Paired domain, protein family^[8].
Paired box 6's part of is recorded as Homeobox, conserved site, protein family^[9].
Paired box 6's has part is recorded as Homeobox domain^[10].
Paired box 6's has part is recorded as Paired domain^[11].
Paired box 6's has part is recorded as Homeobox, conserved site^[12].
Paired box 6's RefSeq protein ID is recorded as NP_001231127^[13].
Paired box 6's RefSeq protein ID is recorded as NP_001231129^[14].
Paired box 6's RefSeq protein ID is recorded as NP_001231130^[15].
Paired box 6's RefSeq protein ID is recorded as NP_001231131^[16].
Paired box 6's RefSeq protein ID is recorded as NP_001297073^[17].
Paired box 6's RefSeq protein ID is recorded as NP_001297074^[18].
Paired box 6's RefSeq protein ID is recorded as NP_001297075^[19].
Paired box 6's RefSeq protein ID is recorded as NP_038655^[20].
Paired box 6's molecular function is recorded as DNA-binding transcription factor activity^[21].
Paired box 6's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[22].
Paired box 6's molecular function is recorded as co-SMAD binding^[23].
Paired box 6's molecular function is recorded as HMG box domain binding^[24].
Paired box 6's molecular function is recorded as transcription factor binding^[25].
Paired box 6's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Homeobox-like domain superfamily, Winged helix-like DNA-binding domain superfamily, Homeobox domain, protein family, Paired domain, protein family, Homeobox, conserved site, protein family

Properties

Biological process commitment of neuronal cell to specific neuron type in forebrain, protein localization to organelle, negative regulation of neuron differentiation, cerebral cortex regionalization, regulation of transcription by RNA polymerase II, dorsal/ventral axis specification, telencephalon regionalization, establishment of mitotic spindle orientation, negative regulation of epithelial cell proliferation, negative regulation of cell population proliferation, positive regulation of neuroblast proliferation, cell fate commitment, regulation of transcription, DNA-templated, negative regulation of neural precursor cell proliferation, signal transduction involved in regulation of gene expression, transcription, DNA-templated, embryonic camera-type eye morphogenesis, smoothened signaling pathway, forebrain-midbrain boundary formation, camera-type eye development, lacrimal gland development, negative regulation of protein phosphorylation, cell differentiation, regulation of timing of cell differentiation, regulation of asymmetric cell division, pallium development, retina development in camera-type eye, regulation of gene expression, dorsal/ventral pattern formation, pituitary gland development, regulation of cell migration, axonogenesis, forebrain dorsal/ventral pattern formation, salivary gland morphogenesis, keratinocyte differentiation, axon guidance, multicellular organism development, oligodendrocyte cell fate specification, positive regulation of epithelial cell differentiation, lens development in camera-type eye, eye photoreceptor cell development, cell fate determination, forebrain development, anterior/posterior pattern specification, positive regulation of transcription by RNA polymerase II, negative regulation of transcription by RNA polymerase II, habenula development, regionalization, cellular response to leukemia inhibitory factor, blood vessel development, pancreatic A cell development, transcription by RNA polymerase II, response to wounding, positive regulation of gene expression, glucose homeostasis, positive regulation of transcription, DNA-templated, iris morphogenesis, cornea development in camera-type eye, neural crest cell migration, neuron migration, epithelial cell development, type B pancreatic cell differentiation, pancreatic A cell differentiation, brain development, positive regulation of cell death, regulation of neuron projection development, rhombomere morphogenesis, olfactory bulb development, interkinetic nuclear migration, hindbrain development, positive regulation of cell fate specification, regulation of neuron differentiation, astrocyte differentiation, regulation of neurogenesis, olfactory bulb mitral cell layer development, neural precursor cell proliferation, positive regulation of glucagon secretion, learned vocalization behavior or vocal learning, positive regulation of glutamatergic neuron differentiation, insulin metabolic process, sensory neuron migration, positive regulation of neuron migration, positive regulation of core promoter binding, positive regulation of core promoter binding

Cell component nucleus, transcription regulator complex, intracellular anatomical structure, nucleoplasm, cytosol, cytoplasm

Encoded by Pax6

Found in taxon house mouse

Has part(s) Homeobox domain, Paired domain, Homeobox, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, co-SMAD binding, HMG box domain binding, transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, chromatin binding, protein binding, histone acetyltransferase binding, protein kinase binding, DNA binding, ubiquitin protein ligase binding, DNA-binding transcription factor activity, RNA polymerase II-specific, R-SMAD binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, minor groove of adenine-thymine-rich DNA binding, double-stranded DNA binding, sequence-specific DNA binding

External References (3)

Ensembl protein id ENSMUSP00000129344, ENSMUSP00000106716, ENSMUSP00000139168, ENSMUSP00000106711, ENSMUSP00000106714, ENSMUSP00000106712, ENSMUSP00000087878, ENSMUSP00000106717, ENSMUSP00000087870, ENSMUSP00000106715, ENSMUSP00000119375

Refseq protein id NP_001231127, NP_001231129, NP_001231130, NP_001231131, NP_001297073, NP_001297074, NP_001297075, NP_038655

Uniprot protein id P63015

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Paired box 6 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Paired box 6 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Paired box 6 — UniProt protein ID (P352): P63015. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Paired box 6 — part of (P361): Homeobox-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Paired box 6 — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Paired box 6 — part of (P361): Homeobox domain, protein family. wikidata.org.
[8] ↑ Paired box 6 — part of (P361): Paired domain, protein family. wikidata.org.
[9] ↑ Paired box 6 — part of (P361): Homeobox, conserved site, protein family. wikidata.org.
[10] ↑ Paired box 6 — has part(s) (P527): Homeobox domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Paired box 6 — has part(s) (P527): Paired domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Paired box 6 — has part(s) (P527): Homeobox, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Paired box 6 — RefSeq protein ID (P637): NP_001231127. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Paired box 6 — RefSeq protein ID (P637): NP_001231129. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Paired box 6 — RefSeq protein ID (P637): NP_001231130. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Paired box 6 — RefSeq protein ID (P637): NP_001231131. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Paired box 6 — RefSeq protein ID (P637): NP_001297073. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Paired box 6 — RefSeq protein ID (P637): NP_001297074. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Paired box 6 — RefSeq protein ID (P637): NP_001297075. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Paired box 6 — RefSeq protein ID (P637): NP_038655. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Paired box 6 — molecular function (P680): DNA-binding transcription factor activity. Pax genes and their role in organogenesis. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Paired box 6 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Paired box 6 — molecular function (P680): co-SMAD binding. The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Paired box 6 — molecular function (P680): HMG box domain binding. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Paired box 6 — molecular function (P680): transcription factor binding. Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Paired box 6 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Paired box 6 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Paired box 6. Retrieved May 3, 2026, from https://4ort.xyz/entity/paired-box-6

MLA “Paired box 6.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/paired-box-6.

BibTeX

@misc{4ortxyz_paired-box-6_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Paired box 6}}, year = {2026}, url = {https://4ort.xyz/entity/paired-box-6}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Paired box 6 — https://4ort.xyz/entity/paired-box-6 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/paired-box-6 · Last refreshed: May 3, 2026