Paired box 2

mammalian protein found in Mus musculus

Protein protein Q21988398

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Paired box 2

Summary

Paired box 2 is a protein^[1].

Key Facts

Paired box 2's instance of is recorded as protein^[2].
Paired box 2's subclass of is recorded as protein^[3].
Paired box 2's UniProt protein ID is recorded as P32114^[4].
Paired box 2's part of is recorded as Homeobox-like domain superfamily^[5].
Paired box 2's part of is recorded as Winged helix-like DNA-binding domain superfamily^[6].
Paired box 2's part of is recorded as Paired-box protein 2 C-terminal domain, protein family^[7].
Paired box 2's part of is recorded as Paired domain, protein family^[8].
Paired box 2's has part is recorded as Paired domain^[9].
Paired box 2's has part is recorded as Paired-box protein 2 C-terminal^[10].
Paired box 2's RefSeq protein ID is recorded as NP_035167^[11].
Paired box 2's RefSeq protein ID is recorded as NP_001355672^[12].
Paired box 2's RefSeq protein ID is recorded as NP_001355673^[13].
Paired box 2's RefSeq protein ID is recorded as NP_001355674^[14].
Paired box 2's RefSeq protein ID is recorded as NP_001355675^[15].
Paired box 2's RefSeq protein ID is recorded as NP_001355676^[16].
Paired box 2's RefSeq protein ID is recorded as NP_001355677^[17].
Paired box 2's RefSeq protein ID is recorded as NP_001355678^[18].
Paired box 2's RefSeq protein ID is recorded as NP_001355679^[19].
Paired box 2's RefSeq protein ID is recorded as NP_001355680^[20].
Paired box 2's molecular function is recorded as DNA-binding transcription factor activity^[21].
Paired box 2's molecular function is recorded as superoxide-generating NAD(P)H oxidase activity^[22].
Paired box 2's molecular function is recorded as transcription factor binding^[23].
Paired box 2's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[24].
Paired box 2's molecular function is recorded as transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding^[25].
Paired box 2's molecular function is recorded as C2H2 zinc finger domain binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Homeobox-like domain superfamily, Winged helix-like DNA-binding domain superfamily, Paired-box protein 2 C-terminal domain, protein family, Paired domain, protein family

Properties

Biological process mesonephric tubule formation, cellular response to retinoic acid, ureteric bud development, negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis, optic nerve morphogenesis, positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, ureter morphogenesis, mesenchymal to epithelial transition involved in metanephros morphogenesis, mesonephros development, cellular response to mechanical stimulus, optic cup morphogenesis involved in camera-type eye development, metanephric collecting duct development, metanephros development, cellular response to glucose stimulus, regulation of apoptotic process, cochlea development, dopaminergic neuron differentiation, renal system development, mesonephric tubule development, positive regulation of branching involved in ureteric bud morphogenesis, regulation of transcription, DNA-templated, positive regulation of metanephric DCT cell differentiation, kidney development, transcription, DNA-templated, reactive oxygen species metabolic process, negative regulation of mesenchymal cell apoptotic process involved in metanephros development, metanephric nephron tubule formation, positive regulation of transcription, DNA-templated, central nervous system development, branching involved in ureteric bud morphogenesis, paramesonephric duct development, negative regulation of programmed cell death, pancreas development, vestibulocochlear nerve formation, camera-type eye development, mesodermal cell fate specification, negative regulation of cytolysis, brain morphogenesis, pronephros development, regulation of metanephric nephron tubule epithelial cell differentiation, cell differentiation, ureter development, negative regulation of apoptotic process involved in metanephric collecting duct development, positive regulation of epithelial cell proliferation, metanephric mesenchymal cell differentiation, metanephric epithelium development, negative regulation of apoptotic process, glial cell differentiation, negative regulation of transcription by RNA polymerase II, nephric duct formation, retinal pigment epithelium development, stem cell differentiation, metanephric distal convoluted tubule development, optic nerve structural organization, positive regulation of metanephric glomerulus development, negative regulation of apoptotic process involved in metanephric nephron tubule development, ureter maturation, positive regulation of optic nerve formation, urogenital system development, negative regulation of transcription, DNA-templated, metanephric mesenchyme development, optic chiasma development, regulation of programmed cell death, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, regulation of metanephros size, protein kinase B signaling, mesonephric duct development, pronephric field specification, multicellular organism development, neural tube closure, inner ear morphogenesis, cochlea morphogenesis, cell fate determination, negative regulation of reactive oxygen species metabolic process, optic nerve development, positive regulation of transcription by RNA polymerase II, cellular response to hydrogen peroxide, mesenchymal to epithelial transition, positive regulation of cell population proliferation, animal organ development, ureter morphogenesis

Cell component microtubule organizing center, nucleus, centriolar satellite, nucleolus, Golgi apparatus, transcription regulator complex, protein-DNA complex, protein-containing complex, lysosome

Encoded by Pax2

Found in taxon house mouse

Has part(s) Paired domain, Paired-box protein 2 C-terminal

Imported from wholeness_audit_2026-05-02

Molecular function DNA-binding transcription factor activity, superoxide-generating NAD(P)H oxidase activity, transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding, C2H2 zinc finger domain binding, cis-regulatory region sequence-specific DNA binding, protein binding, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity

External References (2)

Refseq protein id NP_035167, NP_001355672, NP_001355673, NP_001355674, NP_001355675, NP_001355676, NP_001355677, NP_001355678, NP_001355679, NP_001355680

Uniprot protein id P32114

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Paired box 2 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Paired box 2 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Paired box 2 — UniProt protein ID (P352): P32114. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Paired box 2 — part of (P361): Homeobox-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Paired box 2 — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Paired box 2 — part of (P361): Paired-box protein 2 C-terminal domain, protein family. wikidata.org.
[8] ↑ Paired box 2 — part of (P361): Paired domain, protein family. wikidata.org.
[9] ↑ Paired box 2 — has part(s) (P527): Paired domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Paired box 2 — has part(s) (P527): Paired-box protein 2 C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Paired box 2 — RefSeq protein ID (P637): NP_035167. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Paired box 2 — RefSeq protein ID (P637): NP_001355672. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Paired box 2 — RefSeq protein ID (P637): NP_001355673. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Paired box 2 — RefSeq protein ID (P637): NP_001355674. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Paired box 2 — RefSeq protein ID (P637): NP_001355675. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Paired box 2 — RefSeq protein ID (P637): NP_001355676. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Paired box 2 — RefSeq protein ID (P637): NP_001355677. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Paired box 2 — RefSeq protein ID (P637): NP_001355678. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Paired box 2 — RefSeq protein ID (P637): NP_001355679. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Paired box 2 — RefSeq protein ID (P637): NP_001355680. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Paired box 2 — molecular function (P680): DNA-binding transcription factor activity. Pax genes and their role in organogenesis. Retrieved 2019-01-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Paired box 2 — molecular function (P680): superoxide-generating NAD(P)H oxidase activity. Reactive oxygen species in the presence of high glucose alter ureteric bud morphogenesis. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Paired box 2 — molecular function (P680): transcription factor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Paired box 2 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Paired box 2 — molecular function (P680): transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Paired box 2 — molecular function (P680): C2H2 zinc finger domain binding. Repression of Pax-2 by WT1 during normal kidney development. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Paired box 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Paired box 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/paired-box-2-q21988398

MLA “Paired box 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/paired-box-2-q21988398.

BibTeX

@misc{4ortxyz_paired-box-2-q21988398_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Paired box 2}}, year = {2026}, url = {https://4ort.xyz/entity/paired-box-2-q21988398}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Paired box 2 — https://4ort.xyz/entity/paired-box-2-q21988398 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/paired-box-2-q21988398 · Last refreshed: May 3, 2026