OTU deubiquitinase with linear linkage specificity

mammalian protein found in Homo sapiens
Protein protein Q21112127
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Summary

OTU deubiquitinase with linear linkage specificity is a protein[1]. It is known by 7 alternative names across languages and contexts.[2]

Key Facts

  • Part of: Ubiquitin thioesterase otulin[3]
  • Molecular function: cysteine-type peptidase activity[4], thiol-dependent deubiquitinase[5], peptidase activity[6], protein binding[7], hydrolase activity[8]
  • Cell component: cytosol[9], LUBAC complex[10], cytoplasm[11]
  • Biological process: immune system process[12], Wnt signaling pathway[13], proteolysis[14], nucleotide-binding oligomerization domain containing 2 signaling pathway[15], angiogenesis[16], canonical Wnt signaling pathway[17], sprouting angiogenesis[18], protein linear deubiquitination[19], regulation of tumor necrosis factor-mediated signaling pathway[20], negative regulation of NF-kappaB transcription factor activity[21], innate immune response[22], negative regulation of inflammatory response[23], regulation of canonical Wnt signaling pathway[24], protein ubiquitination[25]
  • Encoded by: OTULIN[26]
  • Found in taxon: Homo sapiens[27]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  5. [7] ↑ . The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . UniProt. Retrieved . wikidata.org.
  25. [27] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). OTU deubiquitinase with linear linkage specificity. Retrieved May 3, 2026, from https://4ort.xyz/entity/otu-deubiquitinase-with-linear-linkage-specificity
MLA “OTU deubiquitinase with linear linkage specificity.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/otu-deubiquitinase-with-linear-linkage-specificity.
BibTeX @misc{4ortxyz_otu-deubiquitinase-with-linear-linkage-specificity_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{OTU deubiquitinase with linear linkage specificity}}, year = {2026}, url = {https://4ort.xyz/entity/otu-deubiquitinase-with-linear-linkage-specificity}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): OTU deubiquitinase with linear linkage specificity — https://4ort.xyz/entity/otu-deubiquitinase-with-linear-linkage-specificity (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/otu-deubiquitinase-with-linear-linkage-specificity · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → OTULIN
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → cysteine-type peptidase activity, thiol-dependent deubiquitinase, peptidase activity +4
    + 10 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 3.4.19.12, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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