O-GlcNAcase

mammalian protein found in Rattus norvegicus

Protein protein Q28557781

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O-GlcNAcase

Summary

O-GlcNAcase is a protein^[1].

Key Facts

O-GlcNAcase's instance of is recorded as protein^[2].
O-GlcNAcase's subclass of is recorded as protein^[3].
O-GlcNAcase's UniProt protein ID is recorded as Q8VIJ5^[4].
O-GlcNAcase's part of is recorded as Acyl-CoA N-acyltransferase^[5].
O-GlcNAcase's part of is recorded as Beta-N-acetylglucosaminidase^[6].
O-GlcNAcase's part of is recorded as glycoside hydrolase superfamily^[7].
O-GlcNAcase's RefSeq protein ID is recorded as NP_571979^[8].
O-GlcNAcase's RefSeq protein ID is recorded as XP_017444197^[9].
O-GlcNAcase's RefSeq protein ID is recorded as XP_038939075^[10].
O-GlcNAcase's molecular function is recorded as histone acetyltransferase activity^[11].
O-GlcNAcase's molecular function is recorded as beta-N-acetylglucosaminidase activity^[12].
O-GlcNAcase's molecular function is recorded as hydrolase activity^[13].
O-GlcNAcase's molecular function is recorded as hydrolase activity, acting on glycosyl bonds^[14].
O-GlcNAcase's molecular function is recorded as [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity^[15].
O-GlcNAcase's molecular function is recorded as [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity^[16].
O-GlcNAcase's molecular function is recorded as [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity^[17].
O-GlcNAcase's cell component is recorded as nucleus^[18].
O-GlcNAcase's cell component is recorded as cytoplasm^[19].
O-GlcNAcase's cell component is recorded as mitochondrion^[20].
O-GlcNAcase's biological process is recorded as N-acetylglucosamine metabolic process^[21].
O-GlcNAcase's biological process is recorded as protein targeting to membrane^[22].
O-GlcNAcase's biological process is recorded as ageing^[23].
O-GlcNAcase's biological process is recorded as metabolism^[24].
O-GlcNAcase's biological process is recorded as glycoprotein metabolic process^[25].
O-GlcNAcase's biological process is recorded as positive regulation of calcium ion transport into cytosol^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Subclass of protein

Part of Acyl-CoA N-acyltransferase, Beta-N-acetylglucosaminidase, glycoside hydrolase superfamily

Properties

Biological process N-acetylglucosamine metabolic process, protein targeting to membrane, ageing, metabolism, glycoprotein metabolic process, positive regulation of calcium ion transport into cytosol, negative regulation of cardiac muscle adaptation, histone acetylation, positive regulation of cell killing, positive regulation of insulin secretion, positive regulation of protein-containing complex disassembly, positive regulation of proteolysis, dATP metabolic process, positive regulation of glucose import, response to steroid hormone, positive regulation of DNA metabolic process, positive regulation of mitochondrial depolarization, positive regulation of calcium ion transport, negative regulation of protein glycosylation, positive regulation of growth hormone secretion, necrotic cell death

Cell component nucleus, cytoplasm, mitochondrion

Encoded by Oga

Found in taxon brown rat

Imported from wholeness_audit_2026-05-02

Molecular function histone acetyltransferase activity, beta-N-acetylglucosaminidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity, [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity, [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity

External References (3)

Ensembl protein id ENSRNOP00000059568

Refseq protein id NP_571979, XP_017444197, XP_038939075

Uniprot protein id Q8VIJ5

🏷️ Also known as

en beta-hexosaminidase en beta-N-acetylhexosaminidase en bifunctional protein NCOAT en meningioma-expressed antigen 5 en meningioma expressed antigen 5 (hyaluronidase) en Mgea5 en N-acetyl-beta-D-glucosaminidase en N-acetyl-beta-glucosaminidase en nuclear cytoplasmic O-GlcNAcase and acetyltransferase en Oga en O-GlcNAcase en protein O-GlcNAcase en protein O-GlcNAcase-like

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ O-GlcNAcase — instance of (P31): protein. Q905695. Retrieved 2021-11-17. wikidata.org.
[3] ↑ O-GlcNAcase — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ O-GlcNAcase — UniProt protein ID (P352): Q8VIJ5. Q905695. Retrieved 2021-11-17. wikidata.org.
[5] ↑ O-GlcNAcase — part of (P361): Acyl-CoA N-acyltransferase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ O-GlcNAcase — part of (P361): Beta-N-acetylglucosaminidase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ O-GlcNAcase — part of (P361): glycoside hydrolase superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ O-GlcNAcase — RefSeq protein ID (P637): NP_571979. Q20641742. Retrieved 2021-09-07. wikidata.org.
[9] ↑ O-GlcNAcase — RefSeq protein ID (P637): XP_017444197. Q20641742. Retrieved 2021-09-07. wikidata.org.
[10] ↑ O-GlcNAcase — RefSeq protein ID (P637): XP_038939075. Q20641742. Retrieved 2021-09-07. wikidata.org.
[11] ↑ O-GlcNAcase — molecular function (P680): histone acetyltransferase activity. Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ O-GlcNAcase — molecular function (P680): beta-N-acetylglucosaminidase activity. Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ O-GlcNAcase — molecular function (P680): hydrolase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ O-GlcNAcase — molecular function (P680): hydrolase activity, acting on glycosyl bonds. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ O-GlcNAcase — molecular function (P680): [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ O-GlcNAcase — molecular function (P680): [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ O-GlcNAcase — molecular function (P680): [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ O-GlcNAcase — cell component (P681): nucleus. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ O-GlcNAcase — cell component (P681): cytoplasm. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ O-GlcNAcase — cell component (P681): mitochondrion. Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ O-GlcNAcase — biological process (P682): N-acetylglucosamine metabolic process. Impaired vasodilator activity in deoxycorticosterone acetate-salt hypertension is associated with increased protein O-GlcNAcylation. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ O-GlcNAcase — biological process (P682): protein targeting to membrane. O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ O-GlcNAcase — biological process (P682): ageing. Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ O-GlcNAcase — biological process (P682): metabolism. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ O-GlcNAcase — biological process (P682): glycoprotein metabolic process. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ O-GlcNAcase — biological process (P682): positive regulation of calcium ion transport into cytosol. Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ O-GlcNAcase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_o-glcnacase-q28557781_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{O-GlcNAcase}}, year = {2026}, url = {https://4ort.xyz/entity/o-glcnacase-q28557781}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): O-GlcNAcase — https://4ort.xyz/entity/o-glcnacase-q28557781 (retrieved 2026-05-03)

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