Nucleotide-binding oligomerization domain containing 2

mammalian protein found in Mus musculus

Protein protein Q21990361

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Nucleotide-binding oligomerization domain containing 2

Summary

Nucleotide-binding oligomerization domain containing 2 is a protein^[1].

Key Facts

Nucleotide-binding oligomerization domain containing 2's instance of is recorded as protein^[2].
Nucleotide-binding oligomerization domain containing 2's UniProt protein ID is recorded as Q80SY9^[3].
Nucleotide-binding oligomerization domain containing 2's part of is recorded as Leucine-rich repeat domain superfamily^[4].
Nucleotide-binding oligomerization domain containing 2's part of is recorded as Death-like domain superfamily^[5].
Nucleotide-binding oligomerization domain containing 2's part of is recorded as P-loop containing nucleoside triphosphate hydrolase^[6].
Nucleotide-binding oligomerization domain containing 2's part of is recorded as membrane protein^[7].
Nucleotide-binding oligomerization domain containing 2's part of is recorded as NACHT nucleoside triphosphatase family^[8].
Nucleotide-binding oligomerization domain containing 2's part of is recorded as CARD domain, protein family^[9].
Nucleotide-binding oligomerization domain containing 2's part of is recorded as Deoxyribonuclease, TatD-related, conserved site, protein family^[10].
Nucleotide-binding oligomerization domain containing 2's part of is recorded as Leucine-rich repeat, protein family^[11].
Nucleotide-binding oligomerization domain containing 2's has part is recorded as Leucine-rich repeat^[12].
Nucleotide-binding oligomerization domain containing 2's has part is recorded as NACHT nucleoside triphosphatase domain^[13].
Nucleotide-binding oligomerization domain containing 2's has part is recorded as Deoxyribonuclease, TatD-related, conserved site^[14].
Nucleotide-binding oligomerization domain containing 2's has part is recorded as CARD domain^[15].
Nucleotide-binding oligomerization domain containing 2's RefSeq protein ID is recorded as NP_665856^[16].
Nucleotide-binding oligomerization domain containing 2's RefSeq protein ID is recorded as XP_006531091^[17].
Nucleotide-binding oligomerization domain containing 2's RefSeq protein ID is recorded as XP_006531092^[18].
Nucleotide-binding oligomerization domain containing 2's RefSeq protein ID is recorded as XP_011246692^[19].
Nucleotide-binding oligomerization domain containing 2's RefSeq protein ID is recorded as XP_036009943^[20].
Nucleotide-binding oligomerization domain containing 2's RefSeq protein ID is recorded as XP_036009944^[21].
Nucleotide-binding oligomerization domain containing 2's molecular function is recorded as protein kinase binding^[22].
Nucleotide-binding oligomerization domain containing 2's molecular function is recorded as Hsp90 protein binding^[23].
Nucleotide-binding oligomerization domain containing 2's molecular function is recorded as CARD domain binding^[24].
Nucleotide-binding oligomerization domain containing 2's molecular function is recorded as muramyl dipeptide binding^[25].
Nucleotide-binding oligomerization domain containing 2's molecular function is recorded as Hsp70 protein binding^[26].

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Quick Facts

Instance of protein

Part of Leucine-rich repeat domain superfamily, Death-like domain superfamily, P-loop containing nucleoside triphosphate hydrolase, membrane protein, NACHT nucleoside triphosphatase family, CARD domain, protein family, Deoxyribonuclease, TatD-related, conserved site, protein family, Leucine-rich repeat, protein family

Properties

Biological process activation of immune response, protein complex oligomerization, positive regulation of cytokine production involved in inflammatory response, maintenance of gastrointestinal epithelium, positive regulation of NIK/NF-kappaB signaling, positive regulation of dendritic cell antigen processing and presentation, negative regulation of macrophage apoptotic process, positive regulation of epithelial cell proliferation, cellular response to peptidoglycan, detection of muramyl dipeptide, inflammatory response, signal transduction, positive regulation of interleukin-10 production, negative regulation of NF-kappaB transcription factor activity, regulation of inflammatory response, cellular response to muramyl dipeptide, positive regulation of interleukin-8 production, positive regulation of JNK cascade, positive regulation of nitric-oxide synthase biosynthetic process, response to exogenous dsRNA, positive regulation of humoral immune response mediated by circulating immunoglobulin, negative regulation of interleukin-2 production, defense response to bacterium, positive regulation of oxidoreductase activity, positive regulation of type 2 immune response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, response to lipopolysaccharide, negative regulation of tumor necrosis factor production, positive regulation of prostaglandin-endoperoxide synthase activity, positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria, positive regulation of B cell activation, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of interleukin-12 production, innate immune response, immunoglobulin production involved in immunoglobulin-mediated immune response, positive regulation of phosphatidylinositol 3-kinase activity, negative regulation of interleukin-18 production, positive regulation of ERK1 and ERK2 cascade, intracellular signal transduction, response to peptidoglycan, macrophage inflammatory protein-1 alpha production, positive regulation of interleukin-17 production, nucleotide-binding oligomerization domain containing 2 signaling pathway, negative regulation of interleukin-12 production, positive regulation of stress-activated MAPK cascade, positive regulation of antibacterial peptide biosynthetic process, positive regulation of tumor necrosis factor production, cytokine production involved in immune response, positive regulation of protein ubiquitination, positive regulation of NF-kappaB transcription factor activity, regulation of neutrophil chemotaxis, DNA metabolic process, immune system process, negative regulation of inflammatory response to antigenic stimulus, positive regulation of prostaglandin-E synthase activity, innate immune response in mucosa, defense response to Gram-positive bacterium, positive regulation of Notch signaling pathway, detection of bacterium, positive regulation of phagocytosis, positive regulation of monocyte chemotactic protein-1 production, positive regulation of transcription by RNA polymerase II, defense response, detection of biotic stimulus, negative regulation of toll-like receptor 2 signaling pathway, regulation of apoptotic process, positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of T cell mediated immunity, positive regulation of MAPK cascade, positive regulation of xenophagy, response to muramyl dipeptide, positive regulation of protein K63-linked ubiquitination, positive regulation of MAP kinase activity, positive regulation of innate immune response, positive regulation of dendritic cell cytokine production, positive regulation of cell population proliferation, cellular response to lipopolysaccharide, response to muramyl dipeptide, intracellular signal transduction, defense response to bacterium, positive regulation of I-kappaB kinase/NF-kappaB signaling, cellular response to lipopolysaccharide, response to muramyl dipeptide, negative regulation of interferon-gamma production

Cell component cytoplasm, basolateral plasma membrane, cell surface, plasma membrane, vesicle, cytoskeleton, COP9 signalosome, cytosol, membrane, Golgi apparatus, protein-containing complex, cytoplasm, cytosol, COP9 signalosome

Encoded by Nod2

Found in taxon house mouse

Has part(s) Leucine-rich repeat, NACHT nucleoside triphosphatase domain, Deoxyribonuclease, TatD-related, conserved site, CARD domain

Imported from wholeness_audit_2026-05-02

Molecular function protein kinase binding, Hsp90 protein binding, CARD domain binding, muramyl dipeptide binding, Hsp70 protein binding, endodeoxyribonuclease activity, producing 5'-phosphomonoesters, nucleotide binding, enzyme binding, ATP binding, peptidoglycan binding, protein binding, actin binding, protein-containing complex binding

External References (3)

Ensembl protein id ENSMUSP00000050538, ENSMUSP00000105262, ENSMUSP00000113773

Refseq protein id NP_665856, XP_006531091, XP_006531092, XP_011246692, XP_036009943, XP_036009944

Uniprot protein id Q80SY9

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Nucleotide-binding oligomerization domain containing 2 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Nucleotide-binding oligomerization domain containing 2 — UniProt protein ID (P352): Q80SY9. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Nucleotide-binding oligomerization domain containing 2 — part of (P361): Leucine-rich repeat domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Nucleotide-binding oligomerization domain containing 2 — part of (P361): Death-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Nucleotide-binding oligomerization domain containing 2 — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Nucleotide-binding oligomerization domain containing 2 — part of (P361): membrane protein. wikidata.org.
[8] ↑ Nucleotide-binding oligomerization domain containing 2 — part of (P361): NACHT nucleoside triphosphatase family. wikidata.org.
[9] ↑ Nucleotide-binding oligomerization domain containing 2 — part of (P361): CARD domain, protein family. wikidata.org.
[10] ↑ Nucleotide-binding oligomerization domain containing 2 — part of (P361): Deoxyribonuclease, TatD-related, conserved site, protein family. wikidata.org.
[11] ↑ Nucleotide-binding oligomerization domain containing 2 — part of (P361): Leucine-rich repeat, protein family. wikidata.org.
[12] ↑ Nucleotide-binding oligomerization domain containing 2 — has part(s) (P527): Leucine-rich repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Nucleotide-binding oligomerization domain containing 2 — has part(s) (P527): NACHT nucleoside triphosphatase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Nucleotide-binding oligomerization domain containing 2 — has part(s) (P527): Deoxyribonuclease, TatD-related, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Nucleotide-binding oligomerization domain containing 2 — has part(s) (P527): CARD domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Nucleotide-binding oligomerization domain containing 2 — RefSeq protein ID (P637): NP_665856. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Nucleotide-binding oligomerization domain containing 2 — RefSeq protein ID (P637): XP_006531091. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Nucleotide-binding oligomerization domain containing 2 — RefSeq protein ID (P637): XP_006531092. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Nucleotide-binding oligomerization domain containing 2 — RefSeq protein ID (P637): XP_011246692. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Nucleotide-binding oligomerization domain containing 2 — RefSeq protein ID (P637): XP_036009943. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Nucleotide-binding oligomerization domain containing 2 — RefSeq protein ID (P637): XP_036009944. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Nucleotide-binding oligomerization domain containing 2 — molecular function (P680): protein kinase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Nucleotide-binding oligomerization domain containing 2 — molecular function (P680): Hsp90 protein binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Nucleotide-binding oligomerization domain containing 2 — molecular function (P680): CARD domain binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Nucleotide-binding oligomerization domain containing 2 — molecular function (P680): muramyl dipeptide binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Nucleotide-binding oligomerization domain containing 2 — molecular function (P680): Hsp70 protein binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Nucleotide-binding oligomerization domain containing 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Nucleotide-binding oligomerization domain containing 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/nucleotide-binding-oligomerization-domain-containing-2-q21990361

MLA

“Nucleotide-binding oligomerization domain containing 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nucleotide-binding-oligomerization-domain-containing-2-q21990361.

BibTeX

@misc{4ortxyz_nucleotide-binding-oligomerization-domain-containing-2-q21990361_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Nucleotide-binding oligomerization domain containing 2}}, year = {2026}, url = {https://4ort.xyz/entity/nucleotide-binding-oligomerization-domain-containing-2-q21990361}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Nucleotide-binding oligomerization domain containing 2 — https://4ort.xyz/entity/nucleotide-binding-oligomerization-domain-containing-2-q21990361 (retrieved 2026-05-03)

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