Nuclear receptor subfamily 1 group H member 4

mammalian protein found in Homo sapiens

Protein protein Q1085078

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Nuclear receptor subfamily 1 group H member 4

Summary

Nuclear receptor subfamily 1 group H member 4 is a protein^[1].

Key Facts

Nuclear receptor subfamily 1 group H member 4's instance of is recorded as protein^[2].
Nuclear receptor subfamily 1 group H member 4's physically interacts with is recorded as chenodiol^[3].
Nuclear receptor subfamily 1 group H member 4's physically interacts with is recorded as fexaramine^[4].
Nuclear receptor subfamily 1 group H member 4's physically interacts with is recorded as obeticholic acid^[5].
Nuclear receptor subfamily 1 group H member 4's physically interacts with is recorded as (E)-guggulsterone^[6].
Nuclear receptor subfamily 1 group H member 4's UniProt protein ID is recorded as Q96RI1^[7].
Nuclear receptor subfamily 1 group H member 4's part of is recorded as thyroid hormone receptor^[8].
Nuclear receptor subfamily 1 group H member 4's part of is recorded as Nuclear hormone receptor-like domain superfamily^[9].
Nuclear receptor subfamily 1 group H member 4's part of is recorded as Zinc finger, NHR/GATA-type^[10].
Nuclear receptor subfamily 1 group H member 4's part of is recorded as Nuclear hormone receptor, ligand-binding domain, protein family^[11].
Nuclear receptor subfamily 1 group H member 4's part of is recorded as Zinc finger, nuclear hormone receptor-type, protein family^[12].
Nuclear receptor subfamily 1 group H member 4's has part is recorded as nuclear hormone receptor-type zinc finger^[13].
Nuclear receptor subfamily 1 group H member 4's has part is recorded as Nuclear hormone receptor, ligand-binding domain^[14].
Nuclear receptor subfamily 1 group H member 4's RefSeq protein ID is recorded as NP_001193906^[15].
Nuclear receptor subfamily 1 group H member 4's RefSeq protein ID is recorded as NP_001193907^[16].
Nuclear receptor subfamily 1 group H member 4's RefSeq protein ID is recorded as NP_001193908^[17].
Nuclear receptor subfamily 1 group H member 4's RefSeq protein ID is recorded as NP_001193921^[18].
Nuclear receptor subfamily 1 group H member 4's RefSeq protein ID is recorded as NP_001193922^[19].
Nuclear receptor subfamily 1 group H member 4's RefSeq protein ID is recorded as NP_005114^[20].
Nuclear receptor subfamily 1 group H member 4's RefSeq protein ID is recorded as XP_006719782^[21].
Nuclear receptor subfamily 1 group H member 4's RefSeq protein ID is recorded as XP_011537342^[22].
Nuclear receptor subfamily 1 group H member 4's RefSeq protein ID is recorded as XP_011537343^[23].
Nuclear receptor subfamily 1 group H member 4's RefSeq protein ID is recorded as XP_011537344^[24].
Nuclear receptor subfamily 1 group H member 4's PDB structure ID is recorded as 1OSH^[25].
Nuclear receptor subfamily 1 group H member 4's PDB structure ID is recorded as 3BEJ^[26].

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Quick Facts

Instance of protein

Part of thyroid hormone receptor, Nuclear hormone receptor-like domain superfamily, Zinc finger, NHR/GATA-type, Nuclear hormone receptor, ligand-binding domain, protein family, Zinc finger, nuclear hormone receptor-type, protein family

Properties

Biological process Notch signaling pathway, cellular triglyceride homeostasis, cellular response to organonitrogen compound, regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of ammonia assimilation cycle, toll-like receptor 4 signaling pathway, immune system process, histone H3-R17 methylation, regulation of transcription by RNA polymerase II, positive regulation of glutamate metabolic process, intracellular bile acid receptor signaling pathway, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, transcription, DNA-templated, regulation of low-density lipoprotein particle clearance, regulation of bile acid biosynthetic process, regulation of cholesterol metabolic process, regulation of urea metabolic process, intracellular receptor signaling pathway, negative regulation of bile acid biosynthetic process, cellular response to fatty acid, bile acid and bile salt transport, nitrogen catabolite activation of transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, inflammatory response, innate immune response, signal transduction, steroid hormone mediated signaling pathway, fatty acid homeostasis, positive regulation of insulin receptor signaling pathway, cellular response to lipopolysaccharide, negative regulation of interleukin-2 production, positive regulation of insulin secretion involved in cellular response to glucose stimulus, negative regulation of inflammatory response, glucose homeostasis, negative regulation of NF-kappaB transcription factor activity, positive regulation of adipose tissue development, cell-cell junction assembly, toll-like receptor 9 signaling pathway, negative regulation of monocyte chemotactic protein-1 production, bile acid metabolic process, negative regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of tumor necrosis factor-mediated signaling pathway, defense response to bacterium, negative regulation of interleukin-1 production, negative regulation of tumor necrosis factor production, negative regulation of interleukin-6 production, triglyceride homeostasis, negative regulation of interferon-gamma production, regulation of transcription, DNA-templated, bile acid signaling pathway, positive regulation of transcription by RNA polymerase II, positive regulation of phosphatidic acid biosynthetic process, cholesterol homeostasis, negative regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, lipid metabolism, multicellular organism development, cell differentiation, bile acid signaling pathway, cholesterol homeostasis, positive regulation of transcription by RNA polymerase II, negative regulation of inflammatory response, lipid homeostasis, cellular response to lipopolysaccharide, cellular glucose homeostasis

Cell component nucleoplasm, nucleus, nucleus, RNA polymerase II transcription regulator complex

Encoded by NR1H4

Found in taxon Homo sapiens

Has part(s) nuclear hormone receptor-type zinc finger, Nuclear hormone receptor, ligand-binding domain

Imported from wholeness_audit_2026-05-02

Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, DNA binding, transcription corepressor activity, DNA-binding transcription factor activity, transcription coactivator activity, zinc ion binding, DNA-binding transcription activator activity, RNA polymerase II-specific, metal ion binding, retinoid X receptor binding, steroid hormone receptor activity, bile acid binding, protein binding, nuclear receptor binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, chenodeoxycholic acid binding, transcription cis-regulatory region binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, nuclear receptor activity, bile acid receptor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription cis-regulatory region binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription factor binding, nuclear receptor coactivator activity, bile acid binding, signaling receptor activity, bile acid receptor activity, DNA-binding transcription factor activity, RNA polymerase II-specific

Physically interacts with chenodiol, fexaramine, obeticholic acid, (E)-guggulsterone

External References (5)

Ensembl protein id ENSP00000188403, ENSP00000447149, ENSP00000448978, ENSP00000376712, ENSP00000448506, ENSP00000315442, ENSP00000446584, ENSP00000446760, ENSP00000446861, ENSP00000496908, ENSP00000496824

Freebase id /m/0fbkmg

Pdb structure id 1OSH, 3BEJ, 3DCT, 3DCU, 3FLI, 3FXV, 3GD2, 3HC5, 3HC6, 3L1B, 3OKH, 3OKI, 3OLF, 3OMK, 3OMM, 3OOF, 3OOK, 3RUT, 3RUU, 3RVF, 3P88, 3P89, 4OIV, 4WVD, 4QE6, 4QE8

Refseq protein id NP_001193906, NP_001193907, NP_001193908, NP_001193921, NP_001193922, NP_005114, XP_006719782, XP_011537342, XP_011537343, XP_011537344

Uniprot protein id Q96RI1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Nuclear receptor subfamily 1 group H member 4 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Nuclear receptor subfamily 1 group H member 4 — physically interacts with (P129): chenodiol. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Nuclear receptor subfamily 1 group H member 4 — physically interacts with (P129): fexaramine. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ Nuclear receptor subfamily 1 group H member 4 — physically interacts with (P129): obeticholic acid. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[6] ↑ Nuclear receptor subfamily 1 group H member 4 — physically interacts with (P129): (E)-guggulsterone. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[7] ↑ Nuclear receptor subfamily 1 group H member 4 — UniProt protein ID (P352): Q96RI1. Q905695. Retrieved 2019-11-13. wikidata.org.
[8] ↑ Nuclear receptor subfamily 1 group H member 4 — part of (P361): thyroid hormone receptor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Nuclear receptor subfamily 1 group H member 4 — part of (P361): Nuclear hormone receptor-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Nuclear receptor subfamily 1 group H member 4 — part of (P361): Zinc finger, NHR/GATA-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Nuclear receptor subfamily 1 group H member 4 — part of (P361): Nuclear hormone receptor, ligand-binding domain, protein family. wikidata.org.
[12] ↑ Nuclear receptor subfamily 1 group H member 4 — part of (P361): Zinc finger, nuclear hormone receptor-type, protein family. wikidata.org.
[13] ↑ Nuclear receptor subfamily 1 group H member 4 — has part(s) (P527): nuclear hormone receptor-type zinc finger. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Nuclear receptor subfamily 1 group H member 4 — has part(s) (P527): Nuclear hormone receptor, ligand-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Nuclear receptor subfamily 1 group H member 4 — RefSeq protein ID (P637): NP_001193906. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ Nuclear receptor subfamily 1 group H member 4 — RefSeq protein ID (P637): NP_001193907. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ Nuclear receptor subfamily 1 group H member 4 — RefSeq protein ID (P637): NP_001193908. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ Nuclear receptor subfamily 1 group H member 4 — RefSeq protein ID (P637): NP_001193921. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ Nuclear receptor subfamily 1 group H member 4 — RefSeq protein ID (P637): NP_001193922. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ Nuclear receptor subfamily 1 group H member 4 — RefSeq protein ID (P637): NP_005114. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ Nuclear receptor subfamily 1 group H member 4 — RefSeq protein ID (P637): XP_006719782. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ Nuclear receptor subfamily 1 group H member 4 — RefSeq protein ID (P637): XP_011537342. Q20641742. Retrieved 2020-05-30. wikidata.org.
[23] ↑ Nuclear receptor subfamily 1 group H member 4 — RefSeq protein ID (P637): XP_011537343. Q20641742. Retrieved 2020-05-30. wikidata.org.
[24] ↑ Nuclear receptor subfamily 1 group H member 4 — RefSeq protein ID (P637): XP_011537344. Q20641742. Retrieved 2020-05-30. wikidata.org.
[25] ↑ Nuclear receptor subfamily 1 group H member 4 — PDB structure ID (P638): 1OSH. Q905695. Retrieved 2016-08-09. wikidata.org.
[26] ↑ Nuclear receptor subfamily 1 group H member 4 — PDB structure ID (P638): 3BEJ. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ Nuclear receptor subfamily 1 group H member 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“Nuclear receptor subfamily 1 group H member 4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-4.

BibTeX

@misc{4ortxyz_nuclear-receptor-subfamily-1-group-h-member-4_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Nuclear receptor subfamily 1 group H member 4}}, year = {2026}, url = {https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-4}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Nuclear receptor subfamily 1 group H member 4 — https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-4 (retrieved 2026-05-03)

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