Nuclear receptor subfamily 1 group H member 2

mammalian protein found in Homo sapiens

Protein protein Q21115219

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Nuclear receptor subfamily 1 group H member 2

Summary

Nuclear receptor subfamily 1 group H member 2 is a protein^[1].

Key Facts

Nuclear receptor subfamily 1 group H member 2's instance of is recorded as protein^[2].
Nuclear receptor subfamily 1 group H member 2's physically interacts with is recorded as (25R)-cholest-5-ene-3β,26-diol^[3].
Nuclear receptor subfamily 1 group H member 2's physically interacts with is recorded as desmosterol^[4].
Nuclear receptor subfamily 1 group H member 2's UniProt protein ID is recorded as P55055^[5].
Nuclear receptor subfamily 1 group H member 2's part of is recorded as Nuclear hormone receptor-like domain superfamily^[6].
Nuclear receptor subfamily 1 group H member 2's part of is recorded as Zinc finger, NHR/GATA-type^[7].
Nuclear receptor subfamily 1 group H member 2's part of is recorded as liver X receptor^[8].
Nuclear receptor subfamily 1 group H member 2's part of is recorded as Nuclear hormone receptor, ligand-binding domain, protein family^[9].
Nuclear receptor subfamily 1 group H member 2's part of is recorded as Zinc finger, nuclear hormone receptor-type, protein family^[10].
Nuclear receptor subfamily 1 group H member 2's has part is recorded as nuclear hormone receptor-type zinc finger^[11].
Nuclear receptor subfamily 1 group H member 2's has part is recorded as Nuclear hormone receptor, ligand-binding domain^[12].
Nuclear receptor subfamily 1 group H member 2's RefSeq protein ID is recorded as NP_001243576^[13].
Nuclear receptor subfamily 1 group H member 2's RefSeq protein ID is recorded as NP_009052^[14].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 1P8D^[15].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 1PQ6^[16].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 1PQ9^[17].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 1PQC^[18].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 1UPV^[19].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 1UPW^[20].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 3KFC^[21].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 3L0E^[22].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 4DK7^[23].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 4DK8^[24].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 4RAK^[25].
Nuclear receptor subfamily 1 group H member 2's PDB structure ID is recorded as 5HJP^[26].

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Quick Facts

Instance of protein

Part of Nuclear hormone receptor-like domain superfamily, Zinc finger, NHR/GATA-type, liver X receptor, Nuclear hormone receptor, ligand-binding domain, protein family, Zinc finger, nuclear hormone receptor-type, protein family

Properties

Biological process positive regulation of high-density lipoprotein particle assembly, negative regulation of proteolysis, positive regulation of triglyceride biosynthetic process, positive regulation of protein metabolic process, negative regulation of interferon-gamma-mediated signaling pathway, positive regulation of cholesterol transport, regulation of transcription, DNA-templated, cellular lipid metabolic process, regulation of transcription by RNA polymerase II, positive regulation of secretion of lysosomal enzymes, positive regulation of lipid storage, positive regulation of lipoprotein lipase activity, negative regulation of transcription by RNA polymerase II, positive regulation of fatty acid biosynthetic process, negative regulation of gene expression, transcription, DNA-templated, positive regulation of transcription, DNA-templated, negative regulation of cholesterol storage, negative regulation of pinocytosis, positive regulation of gene expression, retinoic acid receptor signaling pathway, positive regulation of cholesterol efflux, positive regulation of pancreatic juice secretion, lipid homeostasis, negative regulation of lipid transport, transcription initiation from RNA polymerase II promoter, negative regulation of transcription, DNA-templated, negative regulation of macrophage derived foam cell differentiation, positive regulation of transcription by RNA polymerase II, steroid hormone mediated signaling pathway, cholesterol homeostasis, negative regulation of transcription by RNA polymerase II, lipid metabolism, multicellular organism development, cell differentiation, cholesterol homeostasis, positive regulation of transcription by RNA polymerase II, lipid homeostasis, cellular response to lipopolysaccharide, negative regulation of cold-induced thermogenesis, negative regulation of transcription by RNA polymerase II, positive regulation of cholesterol efflux, intracellular receptor signaling pathway, cholesterol homeostasis, positive regulation of transcription by RNA polymerase II, lipid homeostasis, negative regulation of cold-induced thermogenesis

Cell component cytoplasm, nucleoplasm, nucleus, nucleus, RNA polymerase II transcription regulator complex

Encoded by NR1H2

Found in taxon Homo sapiens

Has part(s) nuclear hormone receptor-type zinc finger, Nuclear hormone receptor, ligand-binding domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, sequence-specific DNA binding, DNA-binding transcription factor activity, ATPase binding, zinc ion binding, DNA-binding transcription activator activity, RNA polymerase II-specific, metal ion binding, retinoid X receptor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, steroid hormone receptor activity, apolipoprotein A-I receptor binding, nuclear receptor activity, protein binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription cis-regulatory region binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription factor binding, nuclear receptor coactivator activity, signaling receptor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, nuclear receptor activity

Physically interacts with (25R)-cholest-5-ene-3β,26-diol, desmosterol

External References (4)

Ensembl protein id ENSP00000253727, ENSP00000396151, ENSP00000471194, ENSP00000469778, ENSP00000470518, ENSP00000471294, ENSP00000472138, ENSP00000472271, ENSP00000472526, ENSP00000473099, ENSP00000499121

Pdb structure id 1P8D, 1PQ6, 1PQ9, 1PQC, 1UPV, 1UPW, 3KFC, 3L0E, 4DK7, 4DK8, 4RAK, 5HJP, 4NQA, 5I4V

Refseq protein id NP_001243576, NP_009052

Uniprot protein id P55055

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Nuclear receptor subfamily 1 group H member 2 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Nuclear receptor subfamily 1 group H member 2 — physically interacts with (P129): (25R)-cholest-5-ene-3β,26-diol. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Nuclear receptor subfamily 1 group H member 2 — physically interacts with (P129): desmosterol. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ Nuclear receptor subfamily 1 group H member 2 — UniProt protein ID (P352): P55055. Q905695. Retrieved 2019-11-13. wikidata.org.
[6] ↑ Nuclear receptor subfamily 1 group H member 2 — part of (P361): Nuclear hormone receptor-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Nuclear receptor subfamily 1 group H member 2 — part of (P361): Zinc finger, NHR/GATA-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Nuclear receptor subfamily 1 group H member 2 — part of (P361): liver X receptor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Nuclear receptor subfamily 1 group H member 2 — part of (P361): Nuclear hormone receptor, ligand-binding domain, protein family. wikidata.org.
[10] ↑ Nuclear receptor subfamily 1 group H member 2 — part of (P361): Zinc finger, nuclear hormone receptor-type, protein family. wikidata.org.
[11] ↑ Nuclear receptor subfamily 1 group H member 2 — has part(s) (P527): nuclear hormone receptor-type zinc finger. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Nuclear receptor subfamily 1 group H member 2 — has part(s) (P527): Nuclear hormone receptor, ligand-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Nuclear receptor subfamily 1 group H member 2 — RefSeq protein ID (P637): NP_001243576. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Nuclear receptor subfamily 1 group H member 2 — RefSeq protein ID (P637): NP_009052. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 1P8D. Q905695. Retrieved 2016-08-04. wikidata.org.
[16] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 1PQ6. Q905695. Retrieved 2016-08-04. wikidata.org.
[17] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 1PQ9. Q905695. Retrieved 2016-08-04. wikidata.org.
[18] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 1PQC. Q905695. Retrieved 2016-08-04. wikidata.org.
[19] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 1UPV. Q905695. Retrieved 2016-08-04. wikidata.org.
[20] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 1UPW. Q905695. Retrieved 2016-08-04. wikidata.org.
[21] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 3KFC. Q905695. Retrieved 2016-08-04. wikidata.org.
[22] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 3L0E. Q905695. Retrieved 2016-08-04. wikidata.org.
[23] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 4DK7. Q905695. Retrieved 2016-08-04. wikidata.org.
[24] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 4DK8. Q905695. Retrieved 2016-08-04. wikidata.org.
[25] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 4RAK. Q905695. Retrieved 2016-08-04. wikidata.org.
[26] ↑ Nuclear receptor subfamily 1 group H member 2 — PDB structure ID (P638): 5HJP. Q905695. Retrieved 2016-08-04. wikidata.org.

Class ancestry

[1] ↑ Nuclear receptor subfamily 1 group H member 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Nuclear receptor subfamily 1 group H member 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-2

MLA

“Nuclear receptor subfamily 1 group H member 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-2.

BibTeX

@misc{4ortxyz_nuclear-receptor-subfamily-1-group-h-member-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Nuclear receptor subfamily 1 group H member 2}}, year = {2026}, url = {https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Nuclear receptor subfamily 1 group H member 2 — https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-2 · Last refreshed: May 3, 2026