Nuclear factor kappa B subunit 1
mammalian protein found in Homo sapiens
Facts
9 properties- Instance of
- protein
- Part of
- p53-like transcription factor, DNA-binding, Immunoglobulin-like fold, Nuclear factor NF-kappa-B, p105 subunit, Ankyrin repeat-containing domain superfamily, Immunoglobulin E-set, Death-like domain superfamily, Rel homology domain (RHD), DNA-binding domain superfamily, IPT domain, protein family, Rel homology dimerisation domain, protein family, Rel homology domain (RHD), DNA-binding domain, protein family, Ankyrin repeat-containing domain, protein family, NFkappaB IPT domain, protein family, Death domain, protein family, Rel homology domain, conserved site, protein family, Ankyrin repeat, protein family[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]
- Biological process
- cellular response to interleukin-6, positive regulation of canonical Wnt signaling pathway, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, negative regulation of vitamin D biosynthetic process, Fc-epsilon receptor signaling pathway, cellular response to mechanical stimulus, NIK/NF-kappaB signaling, stress-activated MAPK cascade, negative regulation of inflammatory response, apoptotic process, response to muscle stretch, regulation of transcription, DNA-templated, stimulatory C-type lectin receptor signaling pathway, transcription, DNA-templated, positive regulation of transcription, DNA-templated, negative regulation of calcidiol 1-monooxygenase activity, positive regulation of hyaluronan biosynthetic process, membrane protein intracellular domain proteolysis, inflammatory response, I-kappaB kinase/NF-kappaB signaling, positive regulation of miRNA metabolic process, cellular response to nicotine, negative regulation of transcription by RNA polymerase II, positive regulation of macrophage derived foam cell differentiation, positive regulation of NF-kappaB transcription factor activity, negative regulation of cholesterol transport, negative regulation of transcription, DNA-templated, negative regulation of cytokine production, positive regulation of lipid storage, cellular response to dsRNA, T cell receptor signaling pathway, positive regulation of type I interferon production, positive regulation of transcription by RNA polymerase II, signal transduction, cellular response to lipopolysaccharide, cellular response to interleukin-1, innate immune response, negative regulation of apoptotic process, negative regulation of gene expression, neutrophil degranulation, cellular response to tumor necrosis factor, cellular response to angiotensin, interleukin-1-mediated signaling pathway
- Cell component
- cytoplasm, mitochondrion, nucleus, I-kappaB/NF-kappaB complex, nucleoplasm, extracellular region, cytosol, secretory granule lumen, specific granule lumen, cytosol
- Encoded by
- NFKB1
- Found in taxon
- Homo sapiens
- Has part(s)
- IPT domain, death domain, Rel homology dimerisation domain, ankyrin repeat-containing domain, Rel homology domain, conserved site, ankyrin repeat, Rel homology domain (RHD), DNA-binding domain, NFkappaB IPT domain[17][18][19][20][21][22][23]
- Imported from
- wholeness_audit_2026-05-02
- Molecular function
- DNA-binding transcription factor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, transcription factor binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein homodimerization activity, chromatin binding, protein binding, DNA binding, sequence-specific DNA binding, actinin binding, identical protein binding, transcription cis-regulatory region binding, protein heterodimerization activity, DNA-binding transcription factor activity, RNA polymerase II-specific, chromatin binding
🏷️ Also known as
en DNA-binding factor KBF1
en EBP-1
en NF-kappabeta
en NFKB1
en nuclear factor kappa-B DNA binding subunit
en Nuclear factor kappa B subunit 1
en nuclear factor NF-kappa-B p105 subunit
en nuclear factor NF-kappa-B p50 subunit
en nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
🔖 Identifiers · 7
- Ensembl protein ID
- ENSP00000226574, ENSP00000378297, ENSP00000424790, ENSP00000469340, ENSP00000420904, ENSP00000423877, ENSP00000424815, ENSP00000426147, ENSP00000499031, ENSP00000498904
- MeSH descriptor ID
- D052002
- MeSH tree code
- D12.776.260.600.124, D12.776.660.600.124, D12.776.930.600.124
- RefSeq protein ID
- NP_001158884, NP_001306155, NP_003989, XP_024309836, XP_024309837, NP_001369554, NP_001369555, NP_001369556, NP_001369557
- UMLS CUI
- C0132348
- UniProt protein ID
- P19838
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Summary
Nuclear factor kappa B subunit 1 is a protein[1].