Nuclear factor, erythroid derived 2, like 2

mammalian protein found in Mus musculus

Protein protein Q21493903

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Nuclear factor, erythroid derived 2, like 2

Summary

Nuclear factor, erythroid derived 2, like 2 is a protein^[1].

Key Facts

Nuclear factor, erythroid derived 2, like 2's instance of is recorded as protein^[2].
Nuclear factor, erythroid derived 2, like 2's subclass of is recorded as protein^[3].
Nuclear factor, erythroid derived 2, like 2's UniProt protein ID is recorded as Stephanie Beckert^[4].
Nuclear factor, erythroid derived 2, like 2's part of is recorded as nuclear factor erythroid 2-related factor 2^[5].
Nuclear factor, erythroid derived 2, like 2's part of is recorded as Transcription factor, Skn-1-like, DNA-binding domain superfamily^[6].
Nuclear factor, erythroid derived 2, like 2's part of is recorded as Basic-leucine zipper domain, protein family^[7].
Nuclear factor, erythroid derived 2, like 2's part of is recorded as Basic leucine zipper domain, Maf-type, protein family^[8].
Nuclear factor, erythroid derived 2, like 2's has part is recorded as Basic-leucine zipper domain^[9].
Nuclear factor, erythroid derived 2, like 2's has part is recorded as Basic leucine zipper domain, Maf-type^[10].
Nuclear factor, erythroid derived 2, like 2's RefSeq protein ID is recorded as NP_035032^[11].
Nuclear factor, erythroid derived 2, like 2's RefSeq protein ID is recorded as NP_001386155^[12].
Nuclear factor, erythroid derived 2, like 2's PDB structure ID is recorded as 1X2R^[13].
Nuclear factor, erythroid derived 2, like 2's PDB structure ID is recorded as 2DYH^[14].
Nuclear factor, erythroid derived 2, like 2's PDB structure ID is recorded as 3WN7^[15].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[16].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as DNA binding^[17].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as protein domain specific binding^[18].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as DNA-binding transcription factor activity^[19].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[20].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as protein binding^[21].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as protein heterodimerization activity^[22].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as transcription factor binding^[23].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as transcription cis-regulatory region binding^[24].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as transcription coregulator binding^[25].
Nuclear factor, erythroid derived 2, like 2's molecular function is recorded as sequence-specific DNA binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of nuclear factor erythroid 2-related factor 2, Transcription factor, Skn-1-like, DNA-binding domain superfamily, Basic-leucine zipper domain, protein family, Basic leucine zipper domain, Maf-type, protein family

Properties

Biological process positive regulation of glucose import, negative regulation of endothelial cell apoptotic process, negative regulation of hematopoietic stem cell differentiation, regulation of embryonic development, cellular response to glucose starvation, regulation of transcription, DNA-templated, cellular response to laminar fluid shear stress, positive regulation of transcription from RNA polymerase II promoter in response to stress, cellular response to tumor necrosis factor, proteasomal ubiquitin-independent protein catabolic process, cellular response to fluid shear stress, cell redox homeostasis, transcription, DNA-templated, response to endoplasmic reticulum stress, PERK-mediated unfolded protein response, positive regulation of glutathione biosynthetic process, positive regulation of transcription, DNA-templated, endoplasmic reticulum unfolded protein response, positive regulation of gene expression, positive regulation of reactive oxygen species metabolic process, positive regulation of blood coagulation, protein ubiquitination, cellular response to oxidative stress, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of hydrogen peroxide-induced cell death, inflammatory response, regulation of removal of superoxide radicals, positive regulation of transcription by RNA polymerase II, cellular response to hydrogen peroxide, proteasome-mediated ubiquitin-dependent protein catabolic process, cellular response to hypoxia, ageing, transcription by RNA polymerase II, cellular response to angiotensin, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, negative regulation of cardiac muscle cell apoptotic process, positive regulation of neuron projection development, positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress, positive regulation of blood vessel endothelial cell migration, positive regulation of angiogenesis, aflatoxin catabolic process, negative regulation of cell death, negative regulation of vascular associated smooth muscle cell migration, cell redox homeostasis, cell redox homeostasis, cellular response to oxidative stress, positive regulation of transcription, DNA-templated

Cell component cytoplasm, cytosol, centrosome, plasma membrane, protein-DNA complex, chromatin, nucleus, nucleoplasm, Golgi apparatus, nucleus, cytoplasm

Encoded by Nfe2l2

Found in taxon house mouse

Has part(s) Basic-leucine zipper domain, Basic leucine zipper domain, Maf-type

Imported from wholeness_audit_2026-05-02

Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA binding, protein domain specific binding, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, protein binding, protein heterodimerization activity, transcription factor binding, transcription cis-regulatory region binding, transcription coregulator binding, sequence-specific DNA binding, transcription cis-regulatory region binding, DNA-binding transcription factor activity

External References (4)

Ensembl protein id ENSMUSP00000099733

Pdb structure id 1X2R, 2DYH, 3WN7

Refseq protein id NP_035032, NP_001386155

Uniprot protein id Stephanie Beckert

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Nuclear factor, erythroid derived 2, like 2 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Nuclear factor, erythroid derived 2, like 2 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Nuclear factor, erythroid derived 2, like 2 — UniProt protein ID (P352): Stephanie Beckert. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Nuclear factor, erythroid derived 2, like 2 — part of (P361): nuclear factor erythroid 2-related factor 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Nuclear factor, erythroid derived 2, like 2 — part of (P361): Transcription factor, Skn-1-like, DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Nuclear factor, erythroid derived 2, like 2 — part of (P361): Basic-leucine zipper domain, protein family. wikidata.org.
[8] ↑ Nuclear factor, erythroid derived 2, like 2 — part of (P361): Basic leucine zipper domain, Maf-type, protein family. wikidata.org.
[9] ↑ Nuclear factor, erythroid derived 2, like 2 — has part(s) (P527): Basic-leucine zipper domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Nuclear factor, erythroid derived 2, like 2 — has part(s) (P527): Basic leucine zipper domain, Maf-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Nuclear factor, erythroid derived 2, like 2 — RefSeq protein ID (P637): NP_035032. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Nuclear factor, erythroid derived 2, like 2 — RefSeq protein ID (P637): NP_001386155. Q20641742. Retrieved 2022-01-09. wikidata.org.
[13] ↑ Nuclear factor, erythroid derived 2, like 2 — PDB structure ID (P638): 1X2R. Q905695. Retrieved 2016-08-10. wikidata.org.
[14] ↑ Nuclear factor, erythroid derived 2, like 2 — PDB structure ID (P638): 2DYH. Q905695. Retrieved 2016-08-10. wikidata.org.
[15] ↑ Nuclear factor, erythroid derived 2, like 2 — PDB structure ID (P638): 3WN7. Q905695. Retrieved 2016-08-10. wikidata.org.
[16] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): protein domain specific binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): protein binding. Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): protein heterodimerization activity. PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): transcription factor binding. ERRbeta: a potent inhibitor of Nrf2 transcriptional activity. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): transcription cis-regulatory region binding. GOA. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): transcription coregulator binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Nuclear factor, erythroid derived 2, like 2 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Nuclear factor, erythroid derived 2, like 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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MLA

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BibTeX

@misc{4ortxyz_nuclear-factor-erythroid-derived-2-like-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Nuclear factor, erythroid derived 2, like 2}}, year = {2026}, url = {https://4ort.xyz/entity/nuclear-factor-erythroid-derived-2-like-2}, note = {Accessed: 2026-05-03}}

LLM prompt

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