Nuclear factor, erythroid 2 like 2

mammalian protein found in Homo sapiens

Protein protein Q21119871

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Nuclear factor, erythroid 2 like 2

Summary

Nuclear factor, erythroid 2 like 2 is a protein^[1].

Key Facts

Nuclear factor, erythroid 2 like 2's instance of is recorded as protein^[2].
Nuclear factor, erythroid 2 like 2's UniProt protein ID is recorded as Saussey^[3].
Nuclear factor, erythroid 2 like 2's part of is recorded as nuclear factor erythroid 2-related factor 2^[4].
Nuclear factor, erythroid 2 like 2's part of is recorded as Transcription factor, Skn-1-like, DNA-binding domain superfamily^[5].
Nuclear factor, erythroid 2 like 2's part of is recorded as Basic-leucine zipper domain, protein family^[6].
Nuclear factor, erythroid 2 like 2's part of is recorded as Basic leucine zipper domain, Maf-type, protein family^[7].
Nuclear factor, erythroid 2 like 2's has part is recorded as Basic leucine zipper domain, Maf-type^[8].
Nuclear factor, erythroid 2 like 2's has part is recorded as Basic-leucine zipper domain^[9].
Nuclear factor, erythroid 2 like 2's RefSeq protein ID is recorded as NP_001138884^[10].
Nuclear factor, erythroid 2 like 2's RefSeq protein ID is recorded as NP_001138885^[11].
Nuclear factor, erythroid 2 like 2's RefSeq protein ID is recorded as NP_001300829^[12].
Nuclear factor, erythroid 2 like 2's RefSeq protein ID is recorded as NP_001300830^[13].
Nuclear factor, erythroid 2 like 2's RefSeq protein ID is recorded as NP_001300831^[14].
Nuclear factor, erythroid 2 like 2's RefSeq protein ID is recorded as NP_001300832^[15].
Nuclear factor, erythroid 2 like 2's RefSeq protein ID is recorded as NP_001300833^[16].
Nuclear factor, erythroid 2 like 2's RefSeq protein ID is recorded as NP_006155^[17].
Nuclear factor, erythroid 2 like 2's PDB structure ID is recorded as 2FLU^[18].
Nuclear factor, erythroid 2 like 2's PDB structure ID is recorded as 2LZ1^[19].
Nuclear factor, erythroid 2 like 2's PDB structure ID is recorded as 3ZGC^[20].
Nuclear factor, erythroid 2 like 2's PDB structure ID is recorded as 4IFL^[21].
Nuclear factor, erythroid 2 like 2's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[22].
Nuclear factor, erythroid 2 like 2's molecular function is recorded as DNA binding^[23].
Nuclear factor, erythroid 2 like 2's molecular function is recorded as sequence-specific DNA binding^[24].
Nuclear factor, erythroid 2 like 2's molecular function is recorded as protein domain specific binding^[25].
Nuclear factor, erythroid 2 like 2's molecular function is recorded as DNA-binding transcription factor activity^[26].

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Quick Facts

Instance of protein

Part of nuclear factor erythroid 2-related factor 2, Transcription factor, Skn-1-like, DNA-binding domain superfamily, Basic-leucine zipper domain, protein family, Basic leucine zipper domain, Maf-type, protein family

Properties

Biological process positive regulation of glucose import, negative regulation of endothelial cell apoptotic process, negative regulation of hematopoietic stem cell differentiation, regulation of embryonic development, cellular response to glucose starvation, regulation of transcription, DNA-templated, cellular response to laminar fluid shear stress, positive regulation of transcription from RNA polymerase II promoter in response to stress, cellular response to tumor necrosis factor, proteasomal ubiquitin-independent protein catabolic process, negative regulation of cell death, cellular response to fluid shear stress, cell redox homeostasis, PERK-mediated unfolded protein response, positive regulation of glutathione biosynthetic process, transcription, DNA-templated, response to endoplasmic reticulum stress, positive regulation of ER-associated ubiquitin-dependent protein catabolic process, positive regulation of transcription, DNA-templated, endoplasmic reticulum unfolded protein response, positive regulation of gene expression, positive regulation of reactive oxygen species metabolic process, positive regulation of blood coagulation, positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress, protein ubiquitination, cellular response to oxidative stress, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of hydrogen peroxide-induced cell death, inflammatory response, regulation of removal of superoxide radicals, positive regulation of transcription by RNA polymerase II, cellular response to hydrogen peroxide, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of blood vessel endothelial cell migration, ageing, cellular response to hypoxia, negative regulation of vascular associated smooth muscle cell migration, negative regulation of cardiac muscle cell apoptotic process, transcription by RNA polymerase II, positive regulation of angiogenesis, positive regulation of neuron projection development, aflatoxin catabolic process, cellular response to angiotensin, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, cell redox homeostasis, viral process, cellular response to oxidative stress, positive regulation of transcription, DNA-templated

Cell component cytoplasm, cytosol, centrosome, plasma membrane, protein-DNA complex, chromatin, nucleus, nucleoplasm, Golgi apparatus, nucleus, cytoplasm

Encoded by NFE2L2

Found in taxon Homo sapiens

Has part(s) Basic leucine zipper domain, Maf-type, Basic-leucine zipper domain

Imported from wholeness_audit_2026-05-02

Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA binding, sequence-specific DNA binding, protein domain specific binding, DNA-binding transcription factor activity, transcription cis-regulatory region binding, DNA-binding transcription activator activity, RNA polymerase II-specific, protein binding, transcription coregulator binding, transcription factor binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription cis-regulatory region binding, DNA-binding transcription factor activity

External References (4)

Ensembl protein id ENSP00000380252, ENSP00000380253, ENSP00000411575, ENSP00000467401, ENSP00000391291, ENSP00000391590, ENSP00000400073, ENSP00000410015, ENSP00000412191, ENSP00000416308, ENSP00000464920, ENSP00000468089

Pdb structure id 2FLU, 2LZ1, 3ZGC, 4IFL

Refseq protein id NP_001138884, NP_001138885, NP_001300829, NP_001300830, NP_001300831, NP_001300832, NP_001300833, NP_006155

Uniprot protein id Saussey

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Nuclear factor, erythroid 2 like 2 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Nuclear factor, erythroid 2 like 2 — UniProt protein ID (P352): Saussey. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Nuclear factor, erythroid 2 like 2 — part of (P361): nuclear factor erythroid 2-related factor 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Nuclear factor, erythroid 2 like 2 — part of (P361): Transcription factor, Skn-1-like, DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Nuclear factor, erythroid 2 like 2 — part of (P361): Basic-leucine zipper domain, protein family. wikidata.org.
[7] ↑ Nuclear factor, erythroid 2 like 2 — part of (P361): Basic leucine zipper domain, Maf-type, protein family. wikidata.org.
[8] ↑ Nuclear factor, erythroid 2 like 2 — has part(s) (P527): Basic leucine zipper domain, Maf-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Nuclear factor, erythroid 2 like 2 — has part(s) (P527): Basic-leucine zipper domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Nuclear factor, erythroid 2 like 2 — RefSeq protein ID (P637): NP_001138884. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ Nuclear factor, erythroid 2 like 2 — RefSeq protein ID (P637): NP_001138885. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ Nuclear factor, erythroid 2 like 2 — RefSeq protein ID (P637): NP_001300829. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ Nuclear factor, erythroid 2 like 2 — RefSeq protein ID (P637): NP_001300830. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Nuclear factor, erythroid 2 like 2 — RefSeq protein ID (P637): NP_001300831. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ Nuclear factor, erythroid 2 like 2 — RefSeq protein ID (P637): NP_001300832. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ Nuclear factor, erythroid 2 like 2 — RefSeq protein ID (P637): NP_001300833. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ Nuclear factor, erythroid 2 like 2 — RefSeq protein ID (P637): NP_006155. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ Nuclear factor, erythroid 2 like 2 — PDB structure ID (P638): 2FLU. Q905695. Retrieved 2016-08-09. wikidata.org.
[19] ↑ Nuclear factor, erythroid 2 like 2 — PDB structure ID (P638): 2LZ1. Q905695. Retrieved 2016-08-09. wikidata.org.
[20] ↑ Nuclear factor, erythroid 2 like 2 — PDB structure ID (P638): 3ZGC. Q905695. Retrieved 2016-08-09. wikidata.org.
[21] ↑ Nuclear factor, erythroid 2 like 2 — PDB structure ID (P638): 4IFL. Q905695. Retrieved 2016-08-09. wikidata.org.
[22] ↑ Nuclear factor, erythroid 2 like 2 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Nuclear factor, erythroid 2 like 2 — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Nuclear factor, erythroid 2 like 2 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Nuclear factor, erythroid 2 like 2 — molecular function (P680): protein domain specific binding. Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Nuclear factor, erythroid 2 like 2 — molecular function (P680): DNA-binding transcription factor activity. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Nuclear factor, erythroid 2 like 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_nuclear-factor-erythroid-2-like-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Nuclear factor, erythroid 2 like 2}}, year = {2026}, url = {https://4ort.xyz/entity/nuclear-factor-erythroid-2-like-2}, note = {Accessed: 2026-05-03}}

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