Notch receptor 1

mammalian protein found in Homo sapiens

Protein protein Q4044985

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Notch receptor 1

Summary

Notch receptor 1 is a protein^[1].

Key Facts

Notch receptor 1's instance of is recorded as protein^[2].
Notch receptor 1's UniProt protein ID is recorded as P46531^[3].
Notch receptor 1's part of is recorded as Notch-like domain superfamily^[4].
Notch receptor 1's part of is recorded as Neurogenic locus Notch 1^[5].
Notch receptor 1's part of is recorded as Growth factor receptor cysteine-rich domain superfamily^[6].
Notch receptor 1's part of is recorded as Ankyrin repeat-containing domain superfamily^[7].
Notch receptor 1's part of is recorded as Putative uncharacterized transport proteins^[8].
Notch receptor 1's part of is recorded as Notch, NODP domain, protein family^[9].
Notch receptor 1's part of is recorded as Notch proteins^[10].
Notch receptor 1's part of is recorded as Notch, NOD domain, protein family^[11].
Notch receptor 1's part of is recorded as Domain of unknown function DUF3454, notch, protein family^[12].
Notch receptor 1's part of is recorded as Ankyrin repeat-containing domain, protein family^[13].
Notch receptor 1's part of is recorded as EGF-like calcium-binding domain, protein family^[14].
Notch receptor 1's part of is recorded as EGF-like domain, protein family^[15].
Notch receptor 1's part of is recorded as EGF-like, conserved site, protein family^[16].
Notch receptor 1's part of is recorded as EGF-like calcium-binding, conserved site, protein family^[17].
Notch receptor 1's part of is recorded as Ankyrin repeat, protein family^[18].
Notch receptor 1's MeSH descriptor ID is recorded as D051881^[19].
Notch receptor 1's has part is recorded as EGF-type aspartate/asparagine hydroxylation site^[20].
Notch receptor 1's has part is recorded as Notch domain^[21].
Notch receptor 1's has part is recorded as EGF-like calcium-binding, conserved site^[22].
Notch receptor 1's has part is recorded as Notch, NODP domain^[23].
Notch receptor 1's has part is recorded as ankyrin repeat-containing domain^[24].
Notch receptor 1's has part is recorded as Notch, NOD domain^[25].
Notch receptor 1's has part is recorded as EGF-like, conserved site^[26].

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Quick Facts

Instance of protein

Part of Notch-like domain superfamily, Neurogenic locus Notch 1, Growth factor receptor cysteine-rich domain superfamily, Ankyrin repeat-containing domain superfamily, Putative uncharacterized transport proteins, Notch, NODP domain, protein family, Notch proteins, Notch, NOD domain, protein family, Domain of unknown function DUF3454, notch, protein family, Ankyrin repeat-containing domain, protein family, EGF-like calcium-binding domain, protein family, EGF-like domain, protein family, EGF-like, conserved site, protein family, EGF-like calcium-binding, conserved site, protein family, Ankyrin repeat, protein family

Properties

Biological process cardiac vascular smooth muscle cell development, endoderm development, pulmonary valve morphogenesis, positive regulation of endothelial cell differentiation, regulation of somitogenesis, cell differentiation in spinal cord, negative regulation of neuron differentiation, regulation of extracellular matrix assembly, distal tubule development, negative regulation of glial cell proliferation, epithelial to mesenchymal transition involved in endocardial cushion formation, regulation of transcription by RNA polymerase II, aortic valve morphogenesis, oligodendrocyte differentiation, endocardium morphogenesis, negative regulation of osteoblast differentiation, negative regulation of stem cell differentiation, negative regulation of ossification, heart looping, negative regulation of photoreceptor cell differentiation, arterial endothelial cell differentiation, atrioventricular valve morphogenesis, Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation, humoral immune response, foregut morphogenesis, negative regulation of oligodendrocyte differentiation, positive regulation of cardiac muscle cell proliferation, regulation of developmental process, mesenchymal cell development, animal organ regeneration, angiogenesis, spermatogenesis, negative regulation of pro-B cell differentiation, regulation of cardioblast proliferation, hair follicle morphogenesis, vasculogenesis involved in coronary vascular morphogenesis, negative regulation of canonical Wnt signaling pathway, regulation of neurogenesis, negative regulation of cell population proliferation, collecting duct development, positive regulation of neuroblast proliferation, cilium assembly, heart trabecula morphogenesis, atrioventricular node development, negative regulation of myoblast differentiation, cell fate commitment, regulation of transcription, DNA-templated, cellular response to follicle-stimulating hormone stimulus, lung development, negative regulation of inner ear auditory receptor cell differentiation, cardiac septum morphogenesis, ventricular septum morphogenesis, negative regulation of cell differentiation, coronary artery morphogenesis, response to muramyl dipeptide, cardiac left ventricle morphogenesis, in utero embryonic development, negative regulation of cell death, endocardial cell differentiation, transcription, DNA-templated, positive regulation of transcription, DNA-templated, development of the heart, prostate gland epithelium morphogenesis, embryonic limb morphogenesis, growth involved in heart morphogenesis, neural tube development, pericardium morphogenesis, epidermis development, cardiac atrium morphogenesis, transcription initiation from RNA polymerase II promoter, cardiac right atrium morphogenesis, negative regulation of cell-substrate adhesion, cell migration involved in endocardial cushion formation, cell differentiation, venous endothelial cell differentiation, regulation of inner ear auditory receptor cell differentiation, negative regulation of catalytic activity, inflammatory response to antigenic stimulus, positive regulation of astrocyte differentiation, positive regulation of epithelial cell proliferation, cardiac right ventricle formation, endocardial cushion development, cell fate specification, positive regulation of keratinocyte differentiation, positive regulation of glial cell differentiation, negative regulation of neurogenesis, glomerular mesangial cell development, sprouting angiogenesis, glial cell differentiation, negative regulation of transcription by RNA polymerase II, cardiac muscle cell proliferation, secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development, positive regulation of epithelial to mesenchymal transition, ventricular trabecula myocardium morphogenesis, neuronal stem cell population maintenance, negative regulation of cell migration involved in sprouting angiogenesis, response to lipopolysaccharide, compartment pattern specification, immune response, neuron differentiation, epithelial to mesenchymal transition, positive regulation of BMP signaling pathway, skeletal muscle cell differentiation, regulation of gene expression, positive regulation of viral genome replication, regulation of epithelial cell proliferation involved in prostate gland development, negative regulation of transcription, DNA-templated, cardiac ventricle morphogenesis, branching morphogenesis of an epithelial tube, positive regulation of receptor signaling pathway via JAK-STAT, negative regulation of anoikis, Notch signaling involved in heart development, coronary vein morphogenesis, apoptotic process involved in embryonic digit morphogenesis, regulation of cell migration, axonogenesis, tissue regeneration, positive regulation of cell migration, somatic stem cell division, cardiac muscle tissue morphogenesis, negative regulation of endothelial cell chemotaxis, keratinocyte differentiation, negative regulation of BMP signaling pathway, endocardial cushion morphogenesis, endocardium development, multicellular organism development, auditory receptor cell fate commitment, response to corticosteroid, tube formation, determination of left/right symmetry, astrocyte differentiation, negative regulation of calcium ion-dependent exocytosis, brain development, regulation of cell population proliferation, positive regulation of cell population proliferation, negative regulation of myotube differentiation, positive regulation of apoptotic process, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, mitral valve formation, liver development, cardiac chamber formation, forebrain development, cellular response to vascular endothelial growth factor stimulus, neuron fate commitment, regulation of epithelial cell proliferation, regulation of Notch signaling pathway, left/right axis specification, positive regulation of transcription by RNA polymerase II, cardiac epithelial to mesenchymal transition, embryonic hindlimb morphogenesis, positive regulation of aorta morphogenesis, venous blood vessel morphogenesis, Notch signaling pathway, negative regulation of gene expression, negative regulation of growth rate, positive regulation of Ras protein signal transduction, positive regulation of ERK1 and ERK2 cascade, positive regulation of transcription of Notch receptor target, positive regulation of Notch signaling pathway, outflow tract morphogenesis, aortic valve morphogenesis, coronary sinus valve morphogenesis, pulmonary valve morphogenesis, negative regulation of cell proliferation involved in heart valve morphogenesis, negative regulation of extracellular matrix constituent secretion, negative regulation of cardiac muscle hypertrophy, positive regulation of gene expression, homeostasis of number of cells within a tissue, ventricular septum morphogenesis, negative regulation of biomineral tissue development, positive regulation of apoptotic process involved in morphogenesis, positive regulation of cardiac epithelial to mesenchymal transition, negative regulation of cold-induced thermogenesis, negative regulation of transcription by RNA polymerase II, epithelial to mesenchymal transition, heart looping, endocardium development, endocardium morphogenesis, coronary vein morphogenesis, aortic valve morphogenesis, atrioventricular valve morphogenesis, pulmonary valve morphogenesis, epithelial to mesenchymal transition involved in endocardial cushion formation, endocardial cushion morphogenesis, cardiac chamber formation, cardiac ventricle morphogenesis, cardiac atrium morphogenesis, cardiac right atrium morphogenesis, cardiac left ventricle morphogenesis, ventricular trabecula myocardium morphogenesis, growth involved in heart morphogenesis, negative regulation of cell proliferation involved in heart valve morphogenesis, cell migration involved in endocardial cushion formation, negative regulation of extracellular matrix constituent secretion, pericardium morphogenesis, positive regulation of transcription of Notch receptor target, determination of left/right symmetry, positive regulation of cell population proliferation, negative regulation of cell population proliferation, negative regulation of cardiac muscle hypertrophy, positive regulation of gene expression, positive regulation of epithelial to mesenchymal transition, negative regulation of myotube differentiation, mesenchymal cell development, negative regulation of ossification, positive regulation of cell migration, positive regulation of BMP signaling pathway, negative regulation of BMP signaling pathway, negative regulation of catalytic activity, negative regulation of osteoblast differentiation, positive regulation of Notch signaling pathway, negative regulation of transcription, DNA-templated, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of astrocyte differentiation, negative regulation of oligodendrocyte differentiation, negative regulation of neurogenesis, cardiac muscle tissue morphogenesis, positive regulation of cardiac muscle cell proliferation, negative regulation of glial cell proliferation, cardiac epithelial to mesenchymal transition, cardiac septum morphogenesis, arterial endothelial cell differentiation, venous endothelial cell differentiation, cardiac vascular smooth muscle cell development, endocardial cell differentiation, vasculogenesis involved in coronary vascular morphogenesis, coronary artery morphogenesis, Notch signaling involved in heart development, heart trabecula morphogenesis, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, positive regulation of cardiac epithelial to mesenchymal transition, negative regulation of biomineral tissue development, negative regulation of cold-induced thermogenesis, regulation of extracellular matrix assembly, positive regulation of apoptotic process involved in morphogenesis, negative regulation of pro-B cell differentiation, Notch signaling pathway

Cell component cytoplasm, cytosol, membrane, adherens junction, extracellular region, nucleus, cell surface, apical plasma membrane, endoplasmic reticulum, integral component of membrane, Golgi apparatus, receptor complex, plasma membrane, nucleoplasm, MAML1-RBP-Jkappa- ICN1 complex, cell periphery, endoplasmic reticulum membrane, Golgi membrane, acrosomal vesicle, cytoplasmic vesicle, plasma membrane, adherens junction, apical plasma membrane, plasma membrane, cell surface, receptor complex

Encoded by NOTCH1

Found in taxon Homo sapiens

Has part(s) EGF-type aspartate/asparagine hydroxylation site, Notch domain, EGF-like calcium-binding, conserved site, Notch, NODP domain, ankyrin repeat-containing domain, Notch, NOD domain, EGF-like, conserved site, Domain of unknown function DUF3454, notch, ankyrin repeat, EGF-like calcium-binding domain, EGF-like domain

Imported from wholeness_audit_2026-05-02

Molecular function calcium ion binding, DNA-binding transcription factor activity, Notch binding, enzyme inhibitor activity, metal ion binding, enzyme binding, chromatin binding, protein binding, sequence-specific DNA binding, protein heterodimerization activity, chromatin DNA binding, transmembrane signaling receptor activity, signaling receptor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, enzyme inhibitor activity, enzyme binding

External References (8)

Ensembl protein id ENSP00000498587

Mesh descriptor id D051881

Mesh tree code D12.776.543.750.725.500, D12.776.930.770.500

Pdb structure id 1PB5, 1TOZ, 1YYH, 2F8X, 2F8Y, 2HE0, 2VJ3, 3ETO, 3I08, 3L95, 3NBN, 3V79, 4CUD, 4CUE, 4CUF, 4D0E, 4D0F, 5FM9, 5FMA

Refseq protein id NP_060087, XP_011517019

Transporter classification database id 9.B.87.1.12

Umls cui C0144507

Uniprot protein id P46531

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Notch receptor 1 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Notch receptor 1 — UniProt protein ID (P352): P46531. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Notch receptor 1 — part of (P361): Notch-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Notch receptor 1 — part of (P361): Neurogenic locus Notch 1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Notch receptor 1 — part of (P361): Growth factor receptor cysteine-rich domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Notch receptor 1 — part of (P361): Ankyrin repeat-containing domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Notch receptor 1 — part of (P361): Putative uncharacterized transport proteins. Retrieved 2019-10-02. wikidata.org.
[9] ↑ Notch receptor 1 — part of (P361): Notch, NODP domain, protein family. wikidata.org.
[10] ↑ Notch receptor 1 — part of (P361): Notch proteins. wikidata.org.
[11] ↑ Notch receptor 1 — part of (P361): Notch, NOD domain, protein family. wikidata.org.
[12] ↑ Notch receptor 1 — part of (P361): Domain of unknown function DUF3454, notch, protein family. wikidata.org.
[13] ↑ Notch receptor 1 — part of (P361): Ankyrin repeat-containing domain, protein family. wikidata.org.
[14] ↑ Notch receptor 1 — part of (P361): EGF-like calcium-binding domain, protein family. wikidata.org.
[15] ↑ Notch receptor 1 — part of (P361): EGF-like domain, protein family. wikidata.org.
[16] ↑ Notch receptor 1 — part of (P361): EGF-like, conserved site, protein family. wikidata.org.
[17] ↑ Notch receptor 1 — part of (P361): EGF-like calcium-binding, conserved site, protein family. wikidata.org.
[18] ↑ Notch receptor 1 — part of (P361): Ankyrin repeat, protein family. wikidata.org.
[19] ↑ Notch receptor 1 — MeSH descriptor ID (P486): D051881. wikidata.org.
[20] ↑ Notch receptor 1 — has part(s) (P527): EGF-type aspartate/asparagine hydroxylation site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Notch receptor 1 — has part(s) (P527): Notch domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Notch receptor 1 — has part(s) (P527): EGF-like calcium-binding, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Notch receptor 1 — has part(s) (P527): Notch, NODP domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Notch receptor 1 — has part(s) (P527): ankyrin repeat-containing domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Notch receptor 1 — has part(s) (P527): Notch, NOD domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Notch receptor 1 — has part(s) (P527): EGF-like, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Notch receptor 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Notch receptor 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/notch-receptor-1

MLA “Notch receptor 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/notch-receptor-1.

BibTeX

@misc{4ortxyz_notch-receptor-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Notch receptor 1}}, year = {2026}, url = {https://4ort.xyz/entity/notch-receptor-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Notch receptor 1 — https://4ort.xyz/entity/notch-receptor-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/notch-receptor-1 · Last refreshed: May 3, 2026