non-syndromic X-linked intellectual disability

non-syndromic intellectual disability characterized by a X-linked inheritance pattern

MedicalCondition rare_disease Q18965508

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non-syndromic X-linked intellectual disability

Summary

non-syndromic X-linked intellectual disability is a rare disease^[1].

Key Facts

non-syndromic X-linked intellectual disability's instance of is recorded as rare disease^[2].
non-syndromic X-linked intellectual disability's instance of is recorded as class of disease^[3].
non-syndromic X-linked intellectual disability is a type of non-syndromic intellectual disability^[4].
non-syndromic X-linked intellectual disability is a type of X-linked intellectual disability^[5].
non-syndromic X-linked intellectual disability is a type of X-linked disease^[6].
non-syndromic X-linked intellectual disability's genetic association is recorded as ZDHHC15^[7].
non-syndromic X-linked intellectual disability's genetic association is recorded as KIF4A^[8].
non-syndromic X-linked intellectual disability's genetic association is recorded as NEXMIF^[9].
non-syndromic X-linked intellectual disability's genetic association is recorded as GDI1^[10].
non-syndromic X-linked intellectual disability's genetic association is recorded as IQSEC2^[11].
non-syndromic X-linked intellectual disability's genetic association is recorded as DLG3^[12].
non-syndromic X-linked intellectual disability's genetic association is recorded as IL1RAPL1^[13].
non-syndromic X-linked intellectual disability's genetic association is recorded as PAK3^[14].
non-syndromic X-linked intellectual disability's genetic association is recorded as TSPAN7^[15].
non-syndromic X-linked intellectual disability's genetic association is recorded as BRWD3^[16].
non-syndromic X-linked intellectual disability's genetic association is recorded as ZNF711^[17].
non-syndromic X-linked intellectual disability's genetic association is recorded as SYP^[18].
non-syndromic X-linked intellectual disability's genetic association is recorded as FTSJ1^[19].
non-syndromic X-linked intellectual disability's genetic association is recorded as USP9X^[20].
non-syndromic X-linked intellectual disability's genetic association is recorded as RAB39B^[21].
non-syndromic X-linked intellectual disability's genetic association is recorded as ACSL4^[22].
non-syndromic X-linked intellectual disability's genetic association is recorded as ARHGEF6^[23].
non-syndromic X-linked intellectual disability's genetic association is recorded as RPS6KA3^[24].
non-syndromic X-linked intellectual disability's genetic association is recorded as ARX^[25].
non-syndromic X-linked intellectual disability's genetic association is recorded as CLCN4^[26].

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Quick Facts

Instance of rare disease, class of disease

Subclass of non-syndromic intellectual disability, X-linked intellectual disability, X-linked disease

Properties

Exact match purl.obolibrary.org, identifiers.org, www.orpha.net

Genetic association ZDHHC15, KIF4A, NEXMIF, GDI1, IQSEC2, DLG3, IL1RAPL1, PAK3, TSPAN7, BRWD3, ZNF711, SYP, FTSJ1, USP9X, RAB39B, ACSL4, ARHGEF6, RPS6KA3, ARX, CLCN4, THOC2, DDX3X

On focus list of wikimedia project WikiProject Medicine

External References (7)

Disease ontology id DOID:0050776

Gard rare disease id 5613, 3542

Kegg id H00480

Mondo id MONDO_0010230

Omim id 300k (300k–310k, n=36)

Orphanet id 777

Umls cui C0796229

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ non-syndromic X-linked intellectual disability — instance of (P31): rare disease. wikidata.org.
[3] ↑ non-syndromic X-linked intellectual disability — instance of (P31): class of disease. wikidata.org.
[4] ↑ non-syndromic X-linked intellectual disability — subclass of (P279): non-syndromic intellectual disability. Disease Ontology. Retrieved 2020-11-29. wikidata.org.
[5] ↑ non-syndromic X-linked intellectual disability — subclass of (P279): X-linked intellectual disability. wikidata.org.
[6] ↑ non-syndromic X-linked intellectual disability — subclass of (P279): X-linked disease. Disease Ontology. Retrieved 2020-11-29. wikidata.org.
[7] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): ZDHHC15. Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation. wikidata.org.
[8] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): KIF4A. Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function.. wikidata.org.
[9] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): NEXMIF. Loss of function of KIAA2022 causes mild to severe intellectual disability with an autism spectrum disorder and impairs neurite outgrowth. wikidata.org.
[10] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): GDI1. Mutations in GDI1 are responsible for X-linked non-specific mental retardation. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[11] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): IQSEC2. Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual disability. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[12] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): DLG3. Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[13] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): IL1RAPL1. A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[14] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): PAK3. PAK3 mutation in nonsyndromic X-linked mental retardation. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[15] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): TSPAN7. A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58. wikidata.org.
[16] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): BRWD3. Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly. wikidata.org.
[17] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): ZNF711. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[18] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): SYP. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[19] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): FTSJ1. Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[20] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): USP9X. Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[21] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): RAB39B. Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[22] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): ACSL4. FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[23] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): ARHGEF6. Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. wikidata.org.
[24] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): RPS6KA3. A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[25] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): ARX. Open Targets Platform. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.
[26] ↑ non-syndromic X-linked intellectual disability — genetic association (P2293): CLCN4. Open Targets Platform. Retrieved 2023-08-24. platform.opentargets.org. Provenance: wikidata.org.

Class ancestry

[1] ↑ non-syndromic X-linked intellectual disability is an instance of rare disease (Q929833) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). non-syndromic X-linked intellectual disability. Retrieved May 3, 2026, from https://4ort.xyz/entity/non-syndromic-x-linked-intellectual-disability

MLA

“non-syndromic X-linked intellectual disability.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/non-syndromic-x-linked-intellectual-disability.

BibTeX

@misc{4ortxyz_non-syndromic-x-linked-intellectual-disability_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{non-syndromic X-linked intellectual disability}}, year = {2026}, url = {https://4ort.xyz/entity/non-syndromic-x-linked-intellectual-disability}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): non-syndromic X-linked intellectual disability — https://4ort.xyz/entity/non-syndromic-x-linked-intellectual-disability (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/non-syndromic-x-linked-intellectual-disability · Last refreshed: May 3, 2026

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26d ago · JhealdBatch bot · 2026-07-05 view diff on Wikidata ↗

Mondo id → MONDO_0010230

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Umls cui → C0796229

Disease ontology id → DOID:0050776

+ 10 other properties edited (see Wikidata diff for full list)

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