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NKX2-5

protein-coding gene in the species Homo sapiens
Class type of: protein-coding gene Q17911158

Facts

13 properties
Instance of
gene
Subclass of
protein-coding gene[2]
Chromosome
human chromosome 5[13]
Cytogenetic location
5q35.1[17]
Encodes
NK2 homeobox 5, Homeobox protein Nkx-2.5[10][11]
Expressed in
apex of heart, right auricle of heart, left ventricle, right ventricle, myocardium of left ventricle, cardiac muscle tissue of right atrium, spleen, gonad, vena cava, body of tongue[18][19][20][21][22][23][24][25][26][27]
Found in taxon
Homo sapiens[12]
Genetic association
atrial heart septal defect 7, tetralogy of Fallot[14][15]
Genomic end
172662360, 173235311[6][7]
Genomic start
173232109, 172659112[4][5]
HomoloGene ID
3230[3]
Ortholog
Nkx2-5, Nkx2-5, nkx2.5[8][9]
Strand orientation
reverse strand[16]
🏷️ Also known as
en CHNG5 en CSX en CSX1 en HLHS2 en NK2 homeobox 5 en NKX2-5 en NKX2.5 en NKX2E en NKX4-1 en VSD3 ja Nkx2-5
🔖 Identifiers · 12
OpenAlex ID
C180504324
Ensembl gene ID
ENSG00000183072
Ensembl transcript ID
ENST00000521848, ENST00000329198, ENST00000424406, ENST00000517440
Entrez Gene ID
1482
Exact match
identifiers.org
Freebase ID
/m/03gwrfq
HGNC ID
2488
HGNC gene symbol
NKX2-5
Microsoft Academic ID (discontinued)
180504324
OMIM ID
600584
RefSeq RNA ID
NM_004387, NM_001166175, NM_001166176, XM_017009071
UMLS CUI
C1413784

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Expressed in 5
spleen, gonad, vena cava, left ventricle, right ventricle
← Genetic association 3
tetralogy of Fallot, hypoplastic left heart syndrome, double outlet right ventricle
Chromosome 1
human chromosome 5
Found in taxon 1
Homo sapiens
Genetic association 1
tetralogy of Fallot
Instance of 1
gene
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Summary

NKX2-5 is a gene[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . NCBI homo sapiens annotation release 107. Retrieved . wikidata.org.
  2. [3] ↑ . NCBI Gene. Retrieved . wikidata.org.
  3. [4] ↑ . ensembl Release 106. wikidata.org.
  4. [5] ↑ . ensembl Release 106. wikidata.org.
  5. [6] ↑ . ensembl Release 106. wikidata.org.
  6. [7] ↑ . ensembl Release 106. wikidata.org.
  7. [8] ↑ . HomoloGene build68. omabrowser.org. Provenance: wikidata.org.
  8. [9] ↑ . HomoloGene build68. omabrowser.org. Provenance: wikidata.org.
  9. [10] ↑ . UniProt. Retrieved . wikidata.org.
  10. [11] ↑ . UniProt. Retrieved . wikidata.org.
  11. [12] ↑ . ensembl Release 106. wikidata.org.
  12. [13] ↑ . ensembl Release 106. wikidata.org.
  13. [14] ↑ . UniProt. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  14. [15] ↑ . UniProt. Retrieved . wikidata.org.
  15. [16] ↑ . ensembl Release 106. wikidata.org.
  16. [17] ↑ . NCBI Gene. Retrieved . wikidata.org.
  17. [18] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  18. [19] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  19. [20] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  20. [21] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  21. [22] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  22. [23] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  23. [24] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  24. [25] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  25. [26] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  26. [27] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). NKX2-5. Retrieved November 10, 2026, from https://4ort.xyz/entity/nkx2-5
MLA “NKX2-5.” 4ort.xyz Knowledge Graph, 4ort.xyz, 10 Nov. 2026, https://4ort.xyz/entity/nkx2-5.
BibTeX @misc{4ortxyz_nkx2-5_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{NKX2-5}}, year = {2026}, url = {https://4ort.xyz/entity/nkx2-5}, note = {Accessed: 2026-11-10}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): NKX2-5 — https://4ort.xyz/entity/nkx2-5 (retrieved 2026-11-10)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 25w ago · Mathieu Kappler · 2026-05-20 view diff on Wikidata ↗
    Genetic association → atrial heart septal defect 7, tetralogy of Fallot
    Chromosome → human chromosome 5
    Strand orientation → reverse strand
    Instance of → gene
    + 5 other properties edited (see Wikidata diff for full list)
    "Changed [gsw] labels, descriptions or aliases: QuickStatements 3.0 batch #32527: human gene name and description in Alemannic"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.