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NEDD4 like E3 ubiquitin protein ligase

mammalian protein found in Homo sapiens
Protein protein Q21112132
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Summary

NEDD4 like E3 ubiquitin protein ligase is a protein[1].

Key Facts

  • NEDD4 like E3 ubiquitin protein ligase's instance of is recorded as protein[2].
  • NEDD4 like E3 ubiquitin protein ligase is part of HECT, E3 ligase catalytic domain[3].
  • NEDD4 like E3 ubiquitin protein ligase is part of WW domain superfamily[4].
  • NEDD4 like E3 ubiquitin protein ligase is part of C2 domain superfamily[5].
  • NEDD4 like E3 ubiquitin protein ligase is part of E3 ubiquitin-protein ligase, SMURF1 type[6].
  • NEDD4 like E3 ubiquitin protein ligase is part of HECT domain, protein family[7].
  • NEDD4 like E3 ubiquitin protein ligase is part of C2 domain, protein family[8].
  • NEDD4 like E3 ubiquitin protein ligase is part of WW domain, protein family[9].
  • NEDD4 like E3 ubiquitin protein ligase comprises C2 domain[10].
  • NEDD4 like E3 ubiquitin protein ligase comprises WW domain[11].
  • NEDD4 like E3 ubiquitin protein ligase comprises HECT domain[12].
  • NEDD4 like E3 ubiquitin protein ligase's molecular function is recorded as potassium channel inhibitor activity[13].
  • NEDD4 like E3 ubiquitin protein ligase's molecular function is recorded as sodium channel regulator activity[14].
  • NEDD4 like E3 ubiquitin protein ligase's molecular function is recorded as transmembrane transporter binding[15].
  • NEDD4 like E3 ubiquitin protein ligase's molecular function is recorded as sodium channel inhibitor activity[16].
  • NEDD4 like E3 ubiquitin protein ligase's molecular function is recorded as potassium channel regulator activity[17].
  • NEDD4 like E3 ubiquitin protein ligase's molecular function is recorded as protein binding[18].
  • NEDD4 like E3 ubiquitin protein ligase's molecular function is recorded as transferase activity[19].
  • NEDD4 like E3 ubiquitin protein ligase's molecular function is recorded as ubiquitin-protein transferase activity[20].
  • NEDD4 like E3 ubiquitin protein ligase's molecular function is recorded as ubiquitin protein ligase activity[21].
  • NEDD4 like E3 ubiquitin protein ligase's molecular function is recorded as ubiquitin-protein transferase activity[22].
  • NEDD4 like E3 ubiquitin protein ligase's cell component is recorded as cytosol[23].
  • NEDD4 like E3 ubiquitin protein ligase's cell component is recorded as plasma membrane[24].
  • NEDD4 like E3 ubiquitin protein ligase's cell component is recorded as intracellular anatomical structure[25].
  • NEDD4 like E3 ubiquitin protein ligase's cell component is recorded as nucleoplasm[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . UniProt. Retrieved . wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] ↑ . wikidata.org.
  7. [8] ↑ . wikidata.org.
  8. [9] ↑ . wikidata.org.
  9. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] ↑ . The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). NEDD4 like E3 ubiquitin protein ligase. Retrieved May 3, 2026, from https://4ort.xyz/entity/nedd4-like-e3-ubiquitin-protein-ligase
MLA “NEDD4 like E3 ubiquitin protein ligase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nedd4-like-e3-ubiquitin-protein-ligase.
BibTeX @misc{4ortxyz_nedd4-like-e3-ubiquitin-protein-ligase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{NEDD4 like E3 ubiquitin protein ligase}}, year = {2026}, url = {https://4ort.xyz/entity/nedd4-like-e3-ubiquitin-protein-ligase}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): NEDD4 like E3 ubiquitin protein ligase — https://4ort.xyz/entity/nedd4-like-e3-ubiquitin-protein-ligase (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 13w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → NEDD4L
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → potassium channel inhibitor activity, sodium channel regulator activity, transmembrane transporter binding +7
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 2.3.2.26, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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