NEDD4 like E3 ubiquitin protein ligase

mammalian protein found in Homo sapiens

Protein protein Q21112132

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NEDD4 like E3 ubiquitin protein ligase

Summary

NEDD4 like E3 ubiquitin protein ligase is a protein^[1].

Key Facts

NEDD4 like E3 ubiquitin protein ligase's instance of is recorded as protein^[2].
NEDD4 like E3 ubiquitin protein ligase's UniProt protein ID is recorded as Q96PU5^[3].
NEDD4 like E3 ubiquitin protein ligase's part of is recorded as HECT, E3 ligase catalytic domain^[4].
NEDD4 like E3 ubiquitin protein ligase's part of is recorded as WW domain superfamily^[5].
NEDD4 like E3 ubiquitin protein ligase's part of is recorded as C2 domain superfamily^[6].
NEDD4 like E3 ubiquitin protein ligase's part of is recorded as E3 ubiquitin-protein ligase, SMURF1 type^[7].
NEDD4 like E3 ubiquitin protein ligase's part of is recorded as HECT domain, protein family^[8].
NEDD4 like E3 ubiquitin protein ligase's part of is recorded as C2 domain, protein family^[9].
NEDD4 like E3 ubiquitin protein ligase's part of is recorded as WW domain, protein family^[10].
NEDD4 like E3 ubiquitin protein ligase's has part is recorded as C2 domain^[11].
NEDD4 like E3 ubiquitin protein ligase's has part is recorded as WW domain^[12].
NEDD4 like E3 ubiquitin protein ligase's has part is recorded as HECT domain^[13].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001138436^[14].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001138437^[15].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001138438^[16].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001138439^[17].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001138440^[18].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001138441^[19].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001138442^[20].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001138443^[21].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001230889^[22].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_056092^[23].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_005266715^[24].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_005266717^[25].
NEDD4 like E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_005266720^[26].

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Quick Facts

Instance of protein

Part of HECT, E3 ligase catalytic domain, WW domain superfamily, C2 domain superfamily, E3 ubiquitin-protein ligase, SMURF1 type, HECT domain, protein family, C2 domain, protein family, WW domain, protein family

Properties

Biological process negative regulation of sodium ion transmembrane transport, cell differentiation, positive regulation of caveolin-mediated endocytosis, excretion, positive regulation of protein catabolic process, viral life cycle, sodium ion transport, cellular sodium ion homeostasis, negative regulation of sodium ion transmembrane transporter activity, regulation of membrane potential, regulation of ion transmembrane transport, ventricular cardiac muscle cell action potential, response to metal ion, negative regulation of transcription by RNA polymerase II, protein monoubiquitination, water homeostasis, regulation of membrane depolarization, protein K48-linked ubiquitination, positive regulation of endocytosis, negative regulation of protein localization to cell surface, ion transmembrane transport, negative regulation of potassium ion transmembrane transporter activity, protein ubiquitination, regulation of potassium ion transmembrane transporter activity, regulation of protein catabolic process, negative regulation of potassium ion transmembrane transport, regulation of membrane repolarization, positive regulation of dendrite extension, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, viral process, ubiquitin-dependent protein catabolic process, protein polyubiquitination, ubiquitin-dependent protein catabolic process, protein ubiquitination, regulation of protein stability, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of protein catabolic process, regulation of dendrite morphogenesis, negative regulation of potassium ion transmembrane transport, negative regulation of sodium ion transmembrane transporter activity

Cell component cytosol, plasma membrane, intracellular anatomical structure, nucleoplasm, extracellular exosome, endosome, multivesicular body, Golgi apparatus, cytoplasm, extracellular exosome

Encoded by NEDD4L

Found in taxon Homo sapiens

Has part(s) C2 domain, WW domain, HECT domain

Imported from wholeness_audit_2026-05-02

Molecular function potassium channel inhibitor activity, sodium channel regulator activity, transmembrane transporter binding, sodium channel inhibitor activity, potassium channel regulator activity, protein binding, transferase activity, ubiquitin-protein transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity

External References (4)

Ensembl protein id ENSP00000256830, ENSP00000348847, ENSP00000350569, ENSP00000372301, ENSP00000383199, ENSP00000389406, ENSP00000393395, ENSP00000405440, ENSP00000411947, ENSP00000468546, ENSP00000465669, ENSP00000466776, ENSP00000466789, ENSP00000467072, ENSP00000467768, ENSP00000468332, ENSP00000479462, ENSP00000490696

Pdb structure id 2LAJ, 2LB2, 2LTY, 2MPT, 2NSQ, 2ONI, 3JVZ, 3JW0, 5HPK

Refseq protein id NP_001138436, NP_001138437, NP_001138438, NP_001138439, NP_001138440, NP_001138441, NP_001138442, NP_001138443, NP_001230889, NP_056092, XP_005266715, XP_005266717, XP_005266720, XP_006722484, XP_006722487, XP_006722488, XP_006722489, XP_006722491, XP_006722493, XP_011524189, XP_016881165, XP_016881166, XP_016881167, XP_016881168, XP_016881169, XP_016881170, XP_024306897, XP_024306898, XP_024306899, XP_024306900, XP_024306901, XP_024306902, XP_024306903, XP_024306904, XP_024306905

Uniprot protein id Q96PU5

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ NEDD4 like E3 ubiquitin protein ligase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ NEDD4 like E3 ubiquitin protein ligase — UniProt protein ID (P352): Q96PU5. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ NEDD4 like E3 ubiquitin protein ligase — part of (P361): HECT, E3 ligase catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ NEDD4 like E3 ubiquitin protein ligase — part of (P361): WW domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ NEDD4 like E3 ubiquitin protein ligase — part of (P361): C2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ NEDD4 like E3 ubiquitin protein ligase — part of (P361): E3 ubiquitin-protein ligase, SMURF1 type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ NEDD4 like E3 ubiquitin protein ligase — part of (P361): HECT domain, protein family. wikidata.org.
[9] ↑ NEDD4 like E3 ubiquitin protein ligase — part of (P361): C2 domain, protein family. wikidata.org.
[10] ↑ NEDD4 like E3 ubiquitin protein ligase — part of (P361): WW domain, protein family. wikidata.org.
[11] ↑ NEDD4 like E3 ubiquitin protein ligase — has part(s) (P527): C2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ NEDD4 like E3 ubiquitin protein ligase — has part(s) (P527): WW domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ NEDD4 like E3 ubiquitin protein ligase — has part(s) (P527): HECT domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001138436. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001138437. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001138438. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001138439. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001138440. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001138441. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001138442. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001138443. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001230889. Q20641742. Retrieved 2020-05-30. wikidata.org.
[23] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_056092. Q20641742. Retrieved 2020-05-30. wikidata.org.
[24] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_005266715. Q20641742. Retrieved 2020-05-30. wikidata.org.
[25] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_005266717. Q20641742. Retrieved 2020-05-30. wikidata.org.
[26] ↑ NEDD4 like E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_005266720. Q20641742. Retrieved 2020-05-30. wikidata.org.

Class ancestry

[1] ↑ NEDD4 like E3 ubiquitin protein ligase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). NEDD4 like E3 ubiquitin protein ligase. Retrieved May 3, 2026, from https://4ort.xyz/entity/nedd4-like-e3-ubiquitin-protein-ligase

MLA

“NEDD4 like E3 ubiquitin protein ligase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nedd4-like-e3-ubiquitin-protein-ligase.

BibTeX

@misc{4ortxyz_nedd4-like-e3-ubiquitin-protein-ligase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{NEDD4 like E3 ubiquitin protein ligase}}, year = {2026}, url = {https://4ort.xyz/entity/nedd4-like-e3-ubiquitin-protein-ligase}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): NEDD4 like E3 ubiquitin protein ligase — https://4ort.xyz/entity/nedd4-like-e3-ubiquitin-protein-ligase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/nedd4-like-e3-ubiquitin-protein-ligase · Last refreshed: May 3, 2026