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NEDD4 E3 ubiquitin protein ligase

mammalian protein found in Homo sapiens
Protein protein Q21107331
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Summary

NEDD4 E3 ubiquitin protein ligase is a protein[1].

Key Facts

  • NEDD4 E3 ubiquitin protein ligase's instance of is recorded as protein[2].
  • NEDD4 E3 ubiquitin protein ligase is part of C2 domain superfamily[3].
  • NEDD4 E3 ubiquitin protein ligase is part of WW domain superfamily[4].
  • NEDD4 E3 ubiquitin protein ligase is part of HECT, E3 ligase catalytic domain[5].
  • NEDD4 E3 ubiquitin protein ligase is part of auxiliary protein involved in transmembrane transport[6].
  • NEDD4 E3 ubiquitin protein ligase is part of HECT domain, protein family[7].
  • NEDD4 E3 ubiquitin protein ligase is part of WW domain, protein family[8].
  • NEDD4 E3 ubiquitin protein ligase comprises WW domain[9].
  • NEDD4 E3 ubiquitin protein ligase comprises HECT domain[10].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as protein domain specific binding[11].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as ubiquitin-protein transferase activity[12].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as sodium channel inhibitor activity[13].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as beta-2 adrenergic receptor binding[14].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as ubiquitin binding[15].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as protein binding[16].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as RNA polymerase binding[17].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as proline-rich region binding[18].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as phosphoserine residue binding[19].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as phosphothreonine residue binding[20].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as ionotropic glutamate receptor binding[21].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as transferase activity[22].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as ubiquitin protein ligase activity[23].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as ubiquitin protein ligase activity[24].
  • NEDD4 E3 ubiquitin protein ligase's molecular function is recorded as ubiquitin protein ligase activity[25].
  • NEDD4 E3 ubiquitin protein ligase's cell component is recorded as cytoplasm[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . UniProt. Retrieved . wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [6] ↑ . Retrieved . wikidata.org.
  6. [7] ↑ . wikidata.org.
  7. [8] ↑ . wikidata.org.
  8. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). NEDD4 E3 ubiquitin protein ligase. Retrieved May 3, 2026, from https://4ort.xyz/entity/nedd4-e3-ubiquitin-protein-ligase
MLA “NEDD4 E3 ubiquitin protein ligase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nedd4-e3-ubiquitin-protein-ligase.
BibTeX @misc{4ortxyz_nedd4-e3-ubiquitin-protein-ligase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{NEDD4 E3 ubiquitin protein ligase}}, year = {2026}, url = {https://4ort.xyz/entity/nedd4-e3-ubiquitin-protein-ligase}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): NEDD4 E3 ubiquitin protein ligase — https://4ort.xyz/entity/nedd4-e3-ubiquitin-protein-ligase (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon → Homo sapiens
    Mesh tree code → D05.500.199.500, D08.811.464.938.750.257, D12.776.543.990.493.500
    Wikidata description → mammalian protein found in Homo sapiens
    Pdb structure id → 2KPZ, 2KQ0, 2M3O +10
    + 16 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 2.3.2.26, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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