NEDD4 E3 ubiquitin protein ligase

mammalian protein found in Homo sapiens

Protein protein Q21107331

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NEDD4 E3 ubiquitin protein ligase

Summary

NEDD4 E3 ubiquitin protein ligase is a protein^[1].

Key Facts

NEDD4 E3 ubiquitin protein ligase's instance of is recorded as protein^[2].
NEDD4 E3 ubiquitin protein ligase's UniProt protein ID is recorded as P46934^[3].
NEDD4 E3 ubiquitin protein ligase's part of is recorded as C2 domain superfamily^[4].
NEDD4 E3 ubiquitin protein ligase's part of is recorded as WW domain superfamily^[5].
NEDD4 E3 ubiquitin protein ligase's part of is recorded as HECT, E3 ligase catalytic domain^[6].
NEDD4 E3 ubiquitin protein ligase's part of is recorded as auxiliary protein involved in transmembrane transport^[7].
NEDD4 E3 ubiquitin protein ligase's part of is recorded as HECT domain, protein family^[8].
NEDD4 E3 ubiquitin protein ligase's part of is recorded as WW domain, protein family^[9].
NEDD4 E3 ubiquitin protein ligase's MeSH descriptor ID is recorded as D000075702^[10].
NEDD4 E3 ubiquitin protein ligase's has part is recorded as WW domain^[11].
NEDD4 E3 ubiquitin protein ligase's has part is recorded as HECT domain^[12].
NEDD4 E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001271267^[13].
NEDD4 E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001271268^[14].
NEDD4 E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001271269^[15].
NEDD4 E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001316141^[16].
NEDD4 E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_006145^[17].
NEDD4 E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_940682^[18].
NEDD4 E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_011519926^[19].
NEDD4 E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_011519927^[20].
NEDD4 E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_011519928^[21].
NEDD4 E3 ubiquitin protein ligase's PDB structure ID is recorded as 2KPZ^[22].
NEDD4 E3 ubiquitin protein ligase's PDB structure ID is recorded as 2KQ0^[23].
NEDD4 E3 ubiquitin protein ligase's PDB structure ID is recorded as 2M3O^[24].
NEDD4 E3 ubiquitin protein ligase's PDB structure ID is recorded as 2XBB^[25].
NEDD4 E3 ubiquitin protein ligase's PDB structure ID is recorded as 2XBF^[26].

⭐ Popularity Graph

1/100 established

Quick Facts

Instance of protein

Part of C2 domain superfamily, WW domain superfamily, HECT, E3 ligase catalytic domain, auxiliary protein involved in transmembrane transport, HECT domain, protein family, WW domain, protein family

Properties

Biological process protein targeting to lysosome, adaptive immune response, positive regulation of protein catabolic process, blood vessel morphogenesis, negative regulation of sodium ion transport, cellular response to UV, endocardial cushion development, negative regulation of vascular endothelial growth factor receptor signaling pathway, protein K63-linked ubiquitination, regulation of membrane potential, negative regulation of sodium ion transmembrane transporter activity, regulation of ion transmembrane transport, negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage, outflow tract morphogenesis, receptor internalization, negative regulation of transcription by RNA polymerase II, protein monoubiquitination, receptor catabolic process, nervous system development, regulation of dendrite morphogenesis, response to calcium ion, positive regulation of nucleocytoplasmic transport, neuromuscular junction development, protein ubiquitination, regulation of potassium ion transmembrane transporter activity, lysosomal transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, positive regulation of phosphatidylinositol 3-kinase signaling, progesterone receptor signaling pathway, viral process, neuron projection development, regulation of synapse organization, T cell activation, regulation of macroautophagy, glucocorticoid receptor signaling pathway, protein polyubiquitination, ubiquitin-dependent protein catabolic process, protein targeting to lysosome, neuromuscular junction development, protein ubiquitination, neuron projection development, receptor internalization, receptor catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of protein catabolic process, regulation of dendrite morphogenesis, regulation of synapse organization, negative regulation of sodium ion transmembrane transporter activity

Cell component cytoplasm, cytosol, Golgi apparatus, membrane, ubiquitin ligase complex, plasma membrane, apicolateral plasma membrane, cell cortex, perinuclear region of cytoplasm, chromatin, extracellular exosome, dendritic spine, cytoplasm, dendritic spine, extracellular exosome, glutamatergic synapse, postsynaptic cytosol

Encoded by NEDD4

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) WW domain, HECT domain

Imported from wholeness_audit_2026-05-02

Molecular function protein domain specific binding, ubiquitin-protein transferase activity, sodium channel inhibitor activity, beta-2 adrenergic receptor binding, ubiquitin binding, protein binding, RNA polymerase binding, proline-rich region binding, phosphoserine residue binding, phosphothreonine residue binding, ionotropic glutamate receptor binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase activity, ubiquitin protein ligase activity

External References (8)

Ensembl protein id ENSP00000345530, ENSP00000410613, ENSP00000422705, ENSP00000424827, ENSP00000421047, ENSP00000422455, ENSP00000424471, ENSP00000426051, ENSP00000498181

Mesh descriptor id D000075702

Mesh tree code D05.500.199.500, D08.811.464.938.750.257, D12.776.543.990.493.500

Pdb structure id 2KPZ, 2KQ0, 2M3O, 2XBB, 2XBF, 3B7Y, 4BBN, 4BE8, 4N7F, 4N7H, 5C91, 5AHT, 5C7J

Refseq protein id NP_001271267, NP_001271268, NP_001271269, NP_001316141, NP_006145, NP_940682, XP_011519926, XP_011519927, XP_011519928

Transporter classification database id 8.A.30.1.2

Umls cui C1311453

Uniprot protein id P46934

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ NEDD4 E3 ubiquitin protein ligase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ NEDD4 E3 ubiquitin protein ligase — UniProt protein ID (P352): P46934. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ NEDD4 E3 ubiquitin protein ligase — part of (P361): C2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ NEDD4 E3 ubiquitin protein ligase — part of (P361): WW domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ NEDD4 E3 ubiquitin protein ligase — part of (P361): HECT, E3 ligase catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ NEDD4 E3 ubiquitin protein ligase — part of (P361): auxiliary protein involved in transmembrane transport. Retrieved 2019-10-02. wikidata.org.
[8] ↑ NEDD4 E3 ubiquitin protein ligase — part of (P361): HECT domain, protein family. wikidata.org.
[9] ↑ NEDD4 E3 ubiquitin protein ligase — part of (P361): WW domain, protein family. wikidata.org.
[10] ↑ NEDD4 E3 ubiquitin protein ligase — MeSH descriptor ID (P486): D000075702. wikidata.org.
[11] ↑ NEDD4 E3 ubiquitin protein ligase — has part(s) (P527): WW domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ NEDD4 E3 ubiquitin protein ligase — has part(s) (P527): HECT domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ NEDD4 E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001271267. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ NEDD4 E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001271268. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ NEDD4 E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001271269. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ NEDD4 E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001316141. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ NEDD4 E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_006145. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ NEDD4 E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_940682. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ NEDD4 E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_011519926. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ NEDD4 E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_011519927. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ NEDD4 E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_011519928. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ NEDD4 E3 ubiquitin protein ligase — PDB structure ID (P638): 2KPZ. Q905695. Retrieved 2016-08-09. wikidata.org.
[23] ↑ NEDD4 E3 ubiquitin protein ligase — PDB structure ID (P638): 2KQ0. Q905695. Retrieved 2016-08-09. wikidata.org.
[24] ↑ NEDD4 E3 ubiquitin protein ligase — PDB structure ID (P638): 2M3O. Q905695. Retrieved 2016-08-09. wikidata.org.
[25] ↑ NEDD4 E3 ubiquitin protein ligase — PDB structure ID (P638): 2XBB. Q905695. Retrieved 2016-08-09. wikidata.org.
[26] ↑ NEDD4 E3 ubiquitin protein ligase — PDB structure ID (P638): 2XBF. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ NEDD4 E3 ubiquitin protein ligase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). NEDD4 E3 ubiquitin protein ligase. Retrieved May 3, 2026, from https://4ort.xyz/entity/nedd4-e3-ubiquitin-protein-ligase

MLA

“NEDD4 E3 ubiquitin protein ligase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nedd4-e3-ubiquitin-protein-ligase.

BibTeX

@misc{4ortxyz_nedd4-e3-ubiquitin-protein-ligase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{NEDD4 E3 ubiquitin protein ligase}}, year = {2026}, url = {https://4ort.xyz/entity/nedd4-e3-ubiquitin-protein-ligase}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): NEDD4 E3 ubiquitin protein ligase — https://4ort.xyz/entity/nedd4-e3-ubiquitin-protein-ligase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/nedd4-e3-ubiquitin-protein-ligase · Last refreshed: May 3, 2026