nalbuphine

opioid medication

Class type of: (4R,4aS,7S,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol Q277979

Facts

13 properties

Instance of: type of chemical entity
Subclass of: (4R,4aS,7S,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol
Has use: medication
Canonical SMILES: C1CC(C1)CN2CCC34C5C(CCC3(C2CC6=C4C(=C(C=C6)O)O5)O)O
Chemical formula: C₂₁H₂₇NO₄
Defined daily dose: 80
Isomeric SMILES: C1CC(C1)CN2CC[C@]34[C@@H]5[C@H](CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O)O
Mass: 357.194008
Medical condition treated: pain
Physically interacts with: Opioid receptor delta 1, Opioid receptor, kappa 1, opioid receptor kappa 1, opioid receptor mu 1
Subject has role: opioid antagonist, opioid, narcotic
Substance control status: Schedule III (Russia), Schedule IV (Canada)
World Health Organisation international non-proprietary name: nalbuphine

🏷️ Also known as

en nalbuphine en N-cyclobutylmethyl-4,5alpha-epoxy-3,6alpha,14-morphinantriol ar نالبوفين cs nalbufin de Nalbuphin es Nalbufina fa نالبوفین fi nalbufiini ja ナルブフィン ko 날부핀 ro Nalbufină ru налбуфин uk налбуфін zh 纳布啡

🔖 Identifiers · 37

OpenAlex ID: C2778977083
ATC code: N02AF02
CAS Registry Number: 20594-83-6
ChEBI ID: 7454
ChEMBL ID: CHEMBL895
ChemSpider ID: 4470813
DSSTOX compound identifier: DTXCID103345
DSSTox substance ID: DTXSID8023345
DrugBank ID: DB00844
DrugCentral ID: 1874
EC number: 243-901-6
ECHA Substance Infocard ID: 100.039.895

Show all 37 identifiers +25

Freebase ID: /m/0793_1
Guide to Pharmacology Ligand ID: 1663
Human Metabolome Database ID: HMDB0014982
InChI: InChI=1S/C21H27NO4/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12/h4-5,12,15-16,19,23-25H,1-3,6-11H2/t15-,16+,19-,20-,21+/m0/s1
InChIKey: NETZHAKZCGBWSS-CEDHKZHLSA-N
KEGG ID: C07251, D08246
MassBank accession ID: MSBNK-Waters-WA001514, MSBNK-Waters-WA001515, MSBNK-Waters-WA001516, MSBNK-Waters-WA001517, MSBNK-Waters-WA001518
MeSH concept ID: M0014433
MeSH descriptor ID: D009266
MeSH tree code: D03.132.577.249.606, D03.605.497.639, D03.633.400.686.639, D04.615.723.795.606
MedlinePlus drug identifier: a682668
Microsoft Academic ID (discontinued): 2778977083
NCI Drug Dictionary ID: nalbuphine
NDF-RT ID: N0000147937
PatientsLikeMe treatment ID: nalbuphine
Probes And Drugs ID: PD009692
PubChem CID: 5311304
Quora topic ID: Nubain
Reaxys registry number: 4566620
RxNorm CUI: 7238
SureChEMBL ID: 3766
UMLS CUI: C0027348
UNII: L2T84IQI2K
UniChem compound ID: 130571
WikiProjectMed ID: Nalbuphine

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections

Subject has role 3

narcotic, opioid, opioid antagonist

Has use 1

medication

Medical condition treated 1

pain

← Drug or therapy used for treatment 1

pain

← EU Knowledge Graph item ID 1

Canistro

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Summary

nalbuphine is a type of chemical entity^[1].

Key Facts

Physically interacts with: Opioid receptor delta 1^[2], Opioid receptor, kappa 1^[3], opioid receptor kappa 1^[4], opioid receptor mu 1^[5]
Canonical SMILES: C1CC(C1)CN2CCC34C5C(CCC3(C2CC6=C4C(=C(C=C6)O)O5)O)O^[6]
Chemical formula: C₂₁H₂₇NO₄^[7]
Subclass of: (4R,4aS,7S,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol^[8]
Has use: medication^[9]
Isomeric SMILES: C1CC(C1)CN2CC[C@]34[C@@H]5C@HO^C@HO">[10]
Mass: {'amount': '+357.194008'}^[11]
Medical condition treated: pain^[12]
World Health Organisation international non-proprietary name: nalbuphine^[13]
Subject has role: opioid antagonist^[14], opioid^[15], narcotic^[16]
Defined daily dose: {'amount': '+80'}^[17]
P14834: Schedule III (Russia)^[18], Schedule IV (Canada)^[19]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

Class ancestry

[1] ↑ nalbuphine is an instance of type of chemical entity (Q113145171) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). nalbuphine. Retrieved November 12, 2026, from https://4ort.xyz/entity/nalbuphine

MLA “nalbuphine.” 4ort.xyz Knowledge Graph, 4ort.xyz, 12 Nov. 2026, https://4ort.xyz/entity/nalbuphine.

BibTeX

@misc{4ortxyz_nalbuphine_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{nalbuphine}}, year = {2026}, url = {https://4ort.xyz/entity/nalbuphine}, note = {Accessed: 2026-11-12}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): nalbuphine — https://4ort.xyz/entity/nalbuphine (retrieved 2026-11-12)

Canonical URL: https://4ort.xyz/entity/nalbuphine · Last refreshed: November 12, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

10w ago · Carn · 2026-08-31 view diff on Wikidata ↗

Substance control status → Schedule III (Russia), Schedule IV (Canada)

"Created claim: Substance control status: Schedule IV (Canada), batch #269907"
10w ago · Carn · 2026-08-31 view diff on Wikidata ↗

Subclass of → (4R,4aS,7S,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octa

Has use → medication

Subject has role → opioid antagonist, opioid, narcotic

Instance of → type of chemical entity

+ 5 other properties edited (see Wikidata diff for full list)

"Created claim: Substance control status: Schedule III (Russia), #quickstatements; #temporary_batch_1788165634350"

Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.