Myocardin

mammalian protein found in Mus musculus

Protein protein Q21985830

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Myocardin

Summary

Myocardin is a protein^[1].

Key Facts

Myocardin's instance of is recorded as protein^[2].
Myocardin's subclass of is recorded as protein^[3].
Myocardin's UniProt protein ID is recorded as Q8VIM5^[4].
Myocardin's part of is recorded as SAP domain superfamily^[5].
Myocardin's part of is recorded as myocardin^[6].
Myocardin's part of is recorded as SAP domain, protein family^[7].
Myocardin's part of is recorded as RPEL repeat, protein family^[8].
Myocardin's has part is recorded as RPEL repeat^[9].
Myocardin's has part is recorded as SAP domain^[10].
Myocardin's RefSeq protein ID is recorded as NP_660118^[11].
Myocardin's RefSeq protein ID is recorded as NP_666498^[12].
Myocardin's RefSeq protein ID is recorded as XP_011247195^[13].
Myocardin's RefSeq protein ID is recorded as XP_011247197^[14].
Myocardin's molecular function is recorded as transcription coactivator activity^[15].
Myocardin's molecular function is recorded as R-SMAD binding^[16].
Myocardin's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[17].
Myocardin's molecular function is recorded as transcription coactivator activity^[18].
Myocardin's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[19].
Myocardin's molecular function is recorded as transcription factor binding^[20].
Myocardin's molecular function is recorded as histone deacetylase binding^[21].
Myocardin's molecular function is recorded as core promoter sequence-specific DNA binding^[22].
Myocardin's molecular function is recorded as protein binding^[23].
Myocardin's molecular function is recorded as histone acetyltransferase binding^[24].
Myocardin's molecular function is recorded as cis-regulatory region sequence-specific DNA binding^[25].
Myocardin's molecular function is recorded as RNA polymerase II-specific DNA-binding transcription factor binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of SAP domain superfamily, myocardin, SAP domain, protein family, RPEL repeat, protein family

Properties

Biological process cellular component maintenance, positive regulation of transforming growth factor beta receptor signaling pathway, response to hypoxia, regulation of transcription, DNA-templated, negative regulation of cyclin-dependent protein serine/threonine kinase activity, urinary bladder development, regulation of transcription by RNA polymerase II, vascular associated smooth muscle cell differentiation, cardiac muscle cell differentiation, cardiac ventricle development, regulation of cell growth by extracellular stimulus, positive regulation of DNA-binding transcription factor activity, negative regulation of transcription by RNA polymerase II, smooth muscle cell differentiation, transcription, DNA-templated, regulation of phenotypic switching, vasculogenesis, positive regulation of transcription, DNA-templated, uterus development, negative regulation of skeletal muscle cell differentiation, negative regulation of cardiac muscle cell apoptotic process, development of the heart, muscle cell differentiation, negative regulation of amyloid-beta clearance, positive regulation of smooth muscle cell differentiation, regulation of myoblast differentiation, regulation of histone acetylation, positive regulation of cell population proliferation, negative regulation of myotube differentiation, positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation, positive regulation of cardiac muscle cell differentiation, ventricular cardiac muscle cell differentiation, positive regulation of DNA binding, lung alveolus development, digestive tract development, positive regulation of smooth muscle contraction, ductus arteriosus closure, positive regulation of transcription by RNA polymerase II, negative regulation of cell population proliferation, transcription by RNA polymerase II, positive regulation of gene expression, negative regulation of vascular associated smooth muscle cell proliferation, negative regulation of vascular associated smooth muscle cell migration, negative regulation of platelet-derived growth factor receptor-beta signaling pathway, positive regulation of epithelial to mesenchymal transition, hepatic stellate cell activation, regulation of smooth muscle cell differentiation, cell growth involved in cardiac muscle cell development, positive regulation of cardiac vascular smooth muscle cell differentiation, positive regulation of DNA-binding transcription factor activity, smooth muscle cell differentiation, cardiac muscle cell differentiation

Cell component nuclear speck, SRF-myogenin-E12 complex, nucleus

Encoded by Myocd

Found in taxon house mouse

Has part(s) RPEL repeat, SAP domain

Imported from wholeness_audit_2026-05-02

Molecular function transcription coactivator activity, R-SMAD binding, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription coactivator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor binding, histone deacetylase binding, core promoter sequence-specific DNA binding, protein binding, histone acetyltransferase binding, cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, core promoter sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding

External References (3)

Ensembl protein id ENSMUSP00000098603, ENSMUSP00000099695, ENSMUSP00000104335, ENSMUSP00000115572

Refseq protein id NP_660118, NP_666498, XP_011247195, XP_011247197

Uniprot protein id Q8VIM5

🏷️ Also known as

en basic SAP coiled-coil transcription activator 2 en Myocardin en Myocd en SRF cofactor protein en SRF co-factor protein (cardiac and smooth muscle)

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Myocardin — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Myocardin — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Myocardin — UniProt protein ID (P352): Q8VIM5. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Myocardin — part of (P361): SAP domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Myocardin — part of (P361): myocardin. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Myocardin — part of (P361): SAP domain, protein family. wikidata.org.
[8] ↑ Myocardin — part of (P361): RPEL repeat, protein family. wikidata.org.
[9] ↑ Myocardin — has part(s) (P527): RPEL repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Myocardin — has part(s) (P527): SAP domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Myocardin — RefSeq protein ID (P637): NP_660118. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Myocardin — RefSeq protein ID (P637): NP_666498. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Myocardin — RefSeq protein ID (P637): XP_011247195. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Myocardin — RefSeq protein ID (P637): XP_011247197. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Myocardin — molecular function (P680): transcription coactivator activity. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Myocardin — molecular function (P680): R-SMAD binding. Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Myocardin — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Myocardin — molecular function (P680): transcription coactivator activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Myocardin — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Myocardin — molecular function (P680): transcription factor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Myocardin — molecular function (P680): histone deacetylase binding. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Myocardin — molecular function (P680): core promoter sequence-specific DNA binding. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Myocardin — molecular function (P680): protein binding. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Myocardin — molecular function (P680): histone acetyltransferase binding. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Myocardin — molecular function (P680): cis-regulatory region sequence-specific DNA binding. miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Myocardin — molecular function (P680): RNA polymerase II-specific DNA-binding transcription factor binding. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Myocardin is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Myocardin. Retrieved May 3, 2026, from https://4ort.xyz/entity/myocardin

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BibTeX

@misc{4ortxyz_myocardin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Myocardin}}, year = {2026}, url = {https://4ort.xyz/entity/myocardin}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Myocardin — https://4ort.xyz/entity/myocardin (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/myocardin · Last refreshed: May 3, 2026