MutS homolog 2

mammalian protein found in Mus musculus

Protein protein Q14911693

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MutS homolog 2

Summary

MutS homolog 2 is a protein^[1].

Key Facts

MutS homolog 2's instance of is recorded as protein^[2].
MutS homolog 2's subclass of is recorded as protein^[3].
MutS homolog 2's UniProt protein ID is recorded as P43247^[4].
MutS homolog 2's part of is recorded as DNA mismatch repair protein Msh2^[5].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, N-terminal domain, protein family^[6].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, core domain superfamily^[7].
MutS homolog 2's part of is recorded as P-loop containing nucleoside triphosphate hydrolase^[8].
MutS homolog 2's part of is recorded as MutS, connector domain superfamily^[9].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, connector domain, protein family^[10].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, C-terminal domain, protein family^[11].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, clamp, protein family^[12].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, core domain, protein family^[13].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS-like, N-terminal domain, protein family^[14].
MutS homolog 2's has part is recorded as DNA mismatch repair protein MutS, C-terminal^[15].
MutS homolog 2's has part is recorded as DNA mismatch repair protein MutS, clamp^[16].
MutS homolog 2's has part is recorded as DNA mismatch repair protein MutS, connector domain^[17].
MutS homolog 2's has part is recorded as DNA mismatch repair protein MutS-like, N-terminal^[18].
MutS homolog 2's has part is recorded as DNA mismatch repair protein MutS, core^[19].
MutS homolog 2's RefSeq protein ID is recorded as NP_032654^[20].
MutS homolog 2's molecular function is recorded as nucleotide binding^[21].
MutS homolog 2's molecular function is recorded as centromeric DNA binding^[22].
MutS homolog 2's molecular function is recorded as damaged DNA binding^[23].
MutS homolog 2's molecular function is recorded as DNA binding^[24].
MutS homolog 2's molecular function is recorded as protein homodimerization activity^[25].
MutS homolog 2's molecular function is recorded as mismatched DNA binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of DNA mismatch repair protein Msh2, DNA mismatch repair protein MutS, N-terminal domain, protein family, DNA mismatch repair protein MutS, core domain superfamily, P-loop containing nucleoside triphosphate hydrolase, MutS, connector domain superfamily, DNA mismatch repair protein MutS, connector domain, protein family, DNA mismatch repair protein MutS, C-terminal domain, protein family, DNA mismatch repair protein MutS, clamp, protein family, DNA mismatch repair protein MutS, core domain, protein family, DNA mismatch repair protein MutS-like, N-terminal domain, protein family

Properties

Biological process B cell differentiation, mitotic intra-S DNA damage checkpoint signaling, determination of adult lifespan, response to X-ray, cell cycle, B cell mediated immunity, somatic recombination of immunoglobulin genes involved in immune response, double-strand break repair, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, isotype switching, in utero embryonic development, negative regulation of neuron apoptotic process, germ cell development, oxidative phosphorylation, response to UV-B, male gonad development, somatic hypermutation of immunoglobulin genes, postreplication repair, cellular response to DNA damage stimulus, positive regulation of helicase activity, somatic recombination of immunoglobulin gene segments, negative regulation of DNA recombination, DNA mismatch repair, DNA repair, meiotic gene conversion, maintenance of DNA repeat elements, negative regulation of reciprocal meiotic recombination, positive regulation of isotype switching to IgA isotypes, positive regulation of isotype switching to IgG isotypes, meiotic mismatch repair, pyrimidine dimer repair, DNA mismatch repair, postreplication repair, double-strand break repair, mitotic recombination, response to X-ray, response to UV-B, mitotic intra-S DNA damage checkpoint signaling, interstrand cross-link repair, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, replication fork arrest, positive regulation of helicase activity, protein localization to chromatin, negative regulation of DNA recombination, protein localization to chromatin, somatic recombination of immunoglobulin genes involved in immune response, DNA recombination

Cell component mismatch repair complex, MutSalpha complex, MutSbeta complex, nucleus, nuclear chromosome, mismatch repair complex, MutSalpha complex, nucleus, chromosome

Encoded by Msh2

Found in taxon house mouse

Has part(s) DNA mismatch repair protein MutS, C-terminal, DNA mismatch repair protein MutS, clamp, DNA mismatch repair protein MutS, connector domain, DNA mismatch repair protein MutS-like, N-terminal, DNA mismatch repair protein MutS, core

Imported from wholeness_audit_2026-05-02

Molecular function nucleotide binding, centromeric DNA binding, damaged DNA binding, DNA binding, protein homodimerization activity, mismatched DNA binding, dinucleotide insertion or deletion binding, ADP binding, oxidized purine DNA binding, single-stranded DNA binding, ATPase activity, protein C-terminus binding, single thymine insertion binding, MutLalpha complex binding, enzyme binding, double-stranded DNA binding, dinucleotide repeat insertion binding, ATP binding, protein kinase binding, magnesium ion binding, single guanine insertion binding, guanine/thymine mispair binding, four-way junction DNA binding, Y-form DNA binding, heteroduplex DNA loop binding, double-strand/single-strand DNA junction binding, ATP-dependent activity, acting on DNA, single base insertion or deletion binding, magnesium ion binding, chromatin binding, damaged DNA binding, single-stranded DNA binding, ATP binding, protein kinase binding, guanine/thymine mispair binding, single guanine insertion binding, single thymine insertion binding, dinucleotide repeat insertion binding, oxidized purine DNA binding, MutLalpha complex binding, protein homodimerization activity, ADP binding, chromatin binding, mismatched DNA binding

External References (3)

Ensembl protein id ENSMUSP00000024967, ENSMUSP00000133488, ENSMUSP00000133650

Refseq protein id NP_032654

Uniprot protein id P43247

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ MutS homolog 2 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ MutS homolog 2 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ MutS homolog 2 — UniProt protein ID (P352): P43247. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein Msh2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, N-terminal domain, protein family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, core domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ MutS homolog 2 — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ MutS homolog 2 — part of (P361): MutS, connector domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, connector domain, protein family. wikidata.org.
[11] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, C-terminal domain, protein family. wikidata.org.
[12] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, clamp, protein family. wikidata.org.
[13] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, core domain, protein family. wikidata.org.
[14] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS-like, N-terminal domain, protein family. wikidata.org.
[15] ↑ MutS homolog 2 — has part(s) (P527): DNA mismatch repair protein MutS, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ MutS homolog 2 — has part(s) (P527): DNA mismatch repair protein MutS, clamp. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ MutS homolog 2 — has part(s) (P527): DNA mismatch repair protein MutS, connector domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ MutS homolog 2 — has part(s) (P527): DNA mismatch repair protein MutS-like, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ MutS homolog 2 — has part(s) (P527): DNA mismatch repair protein MutS, core. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ MutS homolog 2 — RefSeq protein ID (P637): NP_032654. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ MutS homolog 2 — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ MutS homolog 2 — molecular function (P680): centromeric DNA binding. Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ MutS homolog 2 — molecular function (P680): damaged DNA binding. HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ MutS homolog 2 — molecular function (P680): DNA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ MutS homolog 2 — molecular function (P680): protein homodimerization activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ MutS homolog 2 — molecular function (P680): mismatched DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ MutS homolog 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). MutS homolog 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/muts-homolog-2-q14911693

MLA “MutS homolog 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/muts-homolog-2-q14911693.

BibTeX

@misc{4ortxyz_muts-homolog-2-q14911693_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{MutS homolog 2}}, year = {2026}, url = {https://4ort.xyz/entity/muts-homolog-2-q14911693}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): MutS homolog 2 — https://4ort.xyz/entity/muts-homolog-2-q14911693 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/muts-homolog-2-q14911693 · Last refreshed: May 3, 2026