MutS homolog 2

mammalian protein found in Homo sapiens

Protein protein Q6717778

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MutS homolog 2

Summary

MutS homolog 2 is a protein^[1].

Key Facts

MutS homolog 2's instance of is recorded as protein^[2].
MutS homolog 2's UniProt protein ID is recorded as P43246^[3].
MutS homolog 2's part of is recorded as DNA mismatch repair protein Msh2^[4].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, N-terminal domain, protein family^[5].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, core domain superfamily^[6].
MutS homolog 2's part of is recorded as P-loop containing nucleoside triphosphate hydrolase^[7].
MutS homolog 2's part of is recorded as MutS, connector domain superfamily^[8].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, connector domain, protein family^[9].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, C-terminal domain, protein family^[10].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, clamp, protein family^[11].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS, core domain, protein family^[12].
MutS homolog 2's part of is recorded as DNA mismatch repair protein MutS-like, N-terminal domain, protein family^[13].
MutS homolog 2's MeSH descriptor ID is recorded as D051718^[14].
MutS homolog 2's has part is recorded as DNA mismatch repair protein MutS-like, N-terminal^[15].
MutS homolog 2's has part is recorded as DNA mismatch repair protein MutS, C-terminal^[16].
MutS homolog 2's has part is recorded as DNA mismatch repair protein MutS, connector domain^[17].
MutS homolog 2's has part is recorded as DNA mismatch repair protein MutS, core^[18].
MutS homolog 2's has part is recorded as DNA mismatch repair protein MutS, clamp^[19].
MutS homolog 2's RefSeq protein ID is recorded as NP_000242^[20].
MutS homolog 2's RefSeq protein ID is recorded as NP_001245210^[21].
MutS homolog 2's RefSeq protein ID is recorded as XP_005264389^[22].
MutS homolog 2's RefSeq protein ID is recorded as XP_011531169^[23].
MutS homolog 2's PDB structure ID is recorded as 2O8B^[24].
MutS homolog 2's PDB structure ID is recorded as 2O8C^[25].
MutS homolog 2's PDB structure ID is recorded as 2O8D^[26].

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Quick Facts

Instance of protein

Part of DNA mismatch repair protein Msh2, DNA mismatch repair protein MutS, N-terminal domain, protein family, DNA mismatch repair protein MutS, core domain superfamily, P-loop containing nucleoside triphosphate hydrolase, MutS, connector domain superfamily, DNA mismatch repair protein MutS, connector domain, protein family, DNA mismatch repair protein MutS, C-terminal domain, protein family, DNA mismatch repair protein MutS, clamp, protein family, DNA mismatch repair protein MutS, core domain, protein family, DNA mismatch repair protein MutS-like, N-terminal domain, protein family

Properties

Biological process negative regulation of neuron apoptotic process, germ cell development, male gonad development, postreplication repair, determination of adult lifespan, in utero embryonic development, cellular response to DNA damage stimulus, oxidative phosphorylation, maintenance of DNA repeat elements, positive regulation of helicase activity, somatic recombination of immunoglobulin gene segments, intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of DNA recombination, somatic recombination of immunoglobulin genes involved in immune response, DNA mismatch repair, B cell differentiation, B cell mediated immunity, DNA repair, positive regulation of isotype switching to IgA isotypes, positive regulation of isotype switching to IgG isotypes, double-strand break repair, meiotic gene conversion, response to X-ray, response to UV-B, somatic hypermutation of immunoglobulin genes, mitotic intra-S DNA damage checkpoint signaling, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of reciprocal meiotic recombination, isotype switching, DNA mismatch repair, postreplication repair, somatic hypermutation of immunoglobulin genes, maintenance of DNA repeat elements, isotype switching, negative regulation of DNA recombination, protein localization to chromatin, somatic recombination of immunoglobulin genes involved in immune response, double-strand break repair, DNA recombination, response to X-ray, response to UV-B, mitotic intra-S DNA damage checkpoint signaling

Cell component MutSbeta complex, membrane, MutSalpha complex, nucleoplasm, mismatch repair complex, nucleus, nucleus, chromosome, membrane, mismatch repair complex, MutSalpha complex, MutSbeta complex

Encoded by MSH2

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) DNA mismatch repair protein MutS-like, N-terminal, DNA mismatch repair protein MutS, C-terminal, DNA mismatch repair protein MutS, connector domain, DNA mismatch repair protein MutS, core, DNA mismatch repair protein MutS, clamp

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, nucleotide binding, protein homodimerization activity, mismatched DNA binding, dinucleotide insertion or deletion binding, ADP binding, centromeric DNA binding, oxidized purine DNA binding, single-stranded DNA binding, damaged DNA binding, ATPase activity, protein C-terminus binding, protein binding, single thymine insertion binding, four-way junction DNA binding, MutLalpha complex binding, enzyme binding, double-stranded DNA binding, dinucleotide repeat insertion binding, ATP binding, protein kinase binding, magnesium ion binding, single guanine insertion binding, guanine/thymine mispair binding, Y-form DNA binding, heteroduplex DNA loop binding, double-strand/single-strand DNA junction binding, ATP-dependent activity, acting on DNA, four-way junction DNA binding, chromatin binding, damaged DNA binding, ATP binding, guanine/thymine mispair binding, single thymine insertion binding, mismatched DNA binding, single guanine insertion binding, dinucleotide repeat insertion binding, oxidized purine DNA binding, MutLalpha complex binding

External References (7)

Ensembl protein id ENSP00000233146, ENSP00000442697, ENSP00000384199, ENSP00000495455, ENSP00000496351, ENSP00000496441, ENSP00000495641, ENSP00000495543

Mesh descriptor id D051718

Mesh tree code D08.811.074.844.750, D08.811.277.040.025.292.750, D12.776.260.556.750, D12.776.624.664.700.130

Pdb structure id 2O8B, 2O8C, 2O8D, 2O8E, 2O8F, 3THW, 3THX, 3THY, 3THZ

Refseq protein id NP_000242, NP_001245210, XP_005264389, XP_011531169

Umls cui C1571621

Uniprot protein id P43246

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ MutS homolog 2 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ MutS homolog 2 — UniProt protein ID (P352): P43246. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein Msh2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, N-terminal domain, protein family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, core domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ MutS homolog 2 — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ MutS homolog 2 — part of (P361): MutS, connector domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, connector domain, protein family. wikidata.org.
[10] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, C-terminal domain, protein family. wikidata.org.
[11] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, clamp, protein family. wikidata.org.
[12] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS, core domain, protein family. wikidata.org.
[13] ↑ MutS homolog 2 — part of (P361): DNA mismatch repair protein MutS-like, N-terminal domain, protein family. wikidata.org.
[14] ↑ MutS homolog 2 — MeSH descriptor ID (P486): D051718. wikidata.org.
[15] ↑ MutS homolog 2 — has part(s) (P527): DNA mismatch repair protein MutS-like, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ MutS homolog 2 — has part(s) (P527): DNA mismatch repair protein MutS, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ MutS homolog 2 — has part(s) (P527): DNA mismatch repair protein MutS, connector domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ MutS homolog 2 — has part(s) (P527): DNA mismatch repair protein MutS, core. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ MutS homolog 2 — has part(s) (P527): DNA mismatch repair protein MutS, clamp. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ MutS homolog 2 — RefSeq protein ID (P637): NP_000242. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ MutS homolog 2 — RefSeq protein ID (P637): NP_001245210. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ MutS homolog 2 — RefSeq protein ID (P637): XP_005264389. Q20641742. Retrieved 2020-05-30. wikidata.org.
[23] ↑ MutS homolog 2 — RefSeq protein ID (P637): XP_011531169. Q20641742. Retrieved 2020-05-30. wikidata.org.
[24] ↑ MutS homolog 2 — PDB structure ID (P638): 2O8B. Q905695. Retrieved 2016-08-09. wikidata.org.
[25] ↑ MutS homolog 2 — PDB structure ID (P638): 2O8C. Q905695. Retrieved 2016-08-09. wikidata.org.
[26] ↑ MutS homolog 2 — PDB structure ID (P638): 2O8D. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ MutS homolog 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). MutS homolog 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/muts-homolog-2

MLA “MutS homolog 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/muts-homolog-2.

BibTeX

@misc{4ortxyz_muts-homolog-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{MutS homolog 2}}, year = {2026}, url = {https://4ort.xyz/entity/muts-homolog-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): MutS homolog 2 — https://4ort.xyz/entity/muts-homolog-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/muts-homolog-2 · Last refreshed: May 3, 2026