MutL homolog 1
mammalian protein found in Mus musculus
Facts
9 properties- Instance of
- protein
- Part of
- Ribosomal protein S5 domain 2-type fold, Ribosomal protein S5 domain 2-type fold, subgroup, Histidine kinase/HSP90-like ATPase superfamily, DNA mismatch repair protein Mlh1, C-terminal domain, protein family, Histidine kinase/HSP90-like ATPase family, DNA mismatch repair protein family, N-terminal domain, protein family, DNA mismatch repair protein, S5 domain 2-like, protein family, DNA mismatch repair, conserved site, protein family[3][4][5][6][7][8][9][10]
- Biological process
- nuclear-transcribed mRNA poly(A) tail shortening, resolution of meiotic recombination intermediates, somatic hypermutation of immunoglobulin genes, reciprocal meiotic recombination, male meiotic nuclear division, meiotic telomere clustering, meiotic metaphase I plate congression, homologous chromosome segregation, cellular response to DNA damage stimulus, male meiosis chromosome segregation, meiotic chromosome segregation, oogenesis, homologous chromosome pairing at meiosis, somatic recombination of immunoglobulin gene segments, spermatogenesis, intrinsic apoptotic signaling pathway in response to DNA damage, isotype switching, negative regulation of mitotic recombination, somatic recombination of immunoglobulin genes involved in immune response, meiotic spindle midzone assembly, DNA mismatch repair, cell cycle, double-strand break repair via nonhomologous end joining, DNA repair, female meiosis chromosome segregation, positive regulation of isotype switching to IgA isotypes, positive regulation of isotype switching to IgG isotypes, meiosis, response to bacterium, DNA mismatch repair, somatic hypermutation of immunoglobulin genes
- Cell component
- chiasma, male germ cell nucleus, chromosome, nucleoplasm, condensed nuclear chromosome, synaptonemal complex, MutLalpha complex, condensed chromosome, late recombination nodule, mismatch repair complex, nucleus, synaptonemal complex, chiasma, mismatch repair complex, MutLalpha complex, chromosome
- Encoded by
- Mlh1
- Found in taxon
- house mouse
- Has part(s)
- DNA mismatch repair, conserved site, DNA mismatch repair protein, S5 domain 2-like, DNA mismatch repair protein Mlh1, C-terminal, Histidine kinase/HSP90-like ATPase domain, DNA mismatch repair protein family, N-terminal[11][12][13][14][15]
- Molecular function
- mismatched DNA binding, chromatin binding, single-stranded DNA binding, MutSalpha complex binding, ATP binding, guanine/thymine mispair binding, nucleotide binding, ATPase activity, chromatin binding, enzyme binding, chromatin binding, single-stranded DNA binding, enzyme binding
🏷️ Also known as
en colon cancer, nonpolyposis type 2
en DNA mismatch repair protein Mlh1
en Mlh1
en MutL homolog 1
en mutL protein homolog 1
🔖 Identifiers · 3
- Ensembl protein ID
- ENSMUSP00000035079, ENSMUSP00000119170, ENSMUSP00000142563, ENSMUSP00000143786
- RefSeq protein ID
- NP_001311451, NP_081086, XP_006512011, XP_006512014, XP_011241237, XP_030099939, XP_036010529, XP_036010530, XP_036010531, XP_036010532, XP_036010533
- UniProt protein ID
- Q9JK91
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Summary
MutL homolog 1 is a protein[1].