Mitogen-activated protein kinase kinase 2

mammalian protein found in Homo sapiens
Protein protein Q21116665
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Mitogen-activated protein kinase kinase 2

Summary

Mitogen-activated protein kinase kinase 2 is a protein[1].

Key Facts

  • Mitogen-activated protein kinase kinase 2's instance of is recorded as protein[2].
  • Mitogen-activated protein kinase kinase 2's physically interacts with is recorded as binimetinib[3].
  • Mitogen-activated protein kinase kinase 2's physically interacts with is recorded as cobimetinib[4].
  • Mitogen-activated protein kinase kinase 2's physically interacts with is recorded as trametinib[5].
  • Mitogen-activated protein kinase kinase 2 is part of Protein kinase-like domain superfamily[6].
  • Mitogen-activated protein kinase kinase 2 is part of Protein kinase domain, protein family[7].
  • Mitogen-activated protein kinase kinase 2 is part of Protein kinase, ATP binding site, protein family[8].
  • Mitogen-activated protein kinase kinase 2 is part of Serine/threonine-protein kinase, active site, protein family[9].
  • Mitogen-activated protein kinase kinase 2 comprises protein kinase domain[10].
  • Mitogen-activated protein kinase kinase 2 comprises protein kinase, ATP binding site[11].
  • Mitogen-activated protein kinase kinase 2 comprises serine/threonine-protein kinase, active site[12].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as transferase activity[13].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as nucleotide binding[14].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as protein kinase activity[15].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as PDZ domain binding[16].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as scaffold protein binding[17].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as protein serine/threonine kinase activator activity[18].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as metal ion binding[19].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as kinase activity[20].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as protein binding[21].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as protein serine/threonine/tyrosine kinase activity[22].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as protein tyrosine kinase activity[23].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as ATP binding[24].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as MAP kinase kinase activity[25].
  • Mitogen-activated protein kinase kinase 2's molecular function is recorded as protein serine/threonine kinase activity[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] . Q905695. Retrieved . wikidata.org.
  2. [3] . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  3. [4] . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  4. [5] . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  5. [6] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] . wikidata.org.
  7. [8] . wikidata.org.
  8. [9] . wikidata.org.
  9. [10] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [11] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [12] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [13] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] . Identification of mitogen‐activated protein/extracellular signal‐responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc‐large. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] . Identification of mitogen‐activated protein/extracellular signal‐responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc‐large. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] . Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] . Identification of interaction between MEK2 and A-Raf-1. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] . The ERK signaling cascade--views from different subcellular compartments. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] . Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Mitogen-activated protein kinase kinase 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-2
MLA “Mitogen-activated protein kinase kinase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-2.
BibTeX @misc{4ortxyz_mitogen-activated-protein-kinase-kinase-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Mitogen-activated protein kinase kinase 2}}, year = {2026}, url = {https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-2}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Mitogen-activated protein kinase kinase 2 — https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-2 (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 4w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon Homo sapiens
    Physically interacts with binimetinib, cobimetinib, trametinib
    Wikidata description mammalian protein found in Homo sapiens
    Mesh tree code D08.811.913.696.620.682.700.565.200, D08.811.913.696.620.682.725.200.200, D12.776.476.563.565.200 +1
    + 15 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.12.2, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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