mitogen-activated protein kinase 1

mammalian protein found in Homo sapiens

Protein protein Q6590503

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mitogen-activated protein kinase 1

Summary

mitogen-activated protein kinase 1 is a protein^[1].

Key Facts

mitogen-activated protein kinase 1's instance of is recorded as protein^[2].
mitogen-activated protein kinase 1's physically interacts with is recorded as ravoxertinib^[3].
mitogen-activated protein kinase 1's physically interacts with is recorded as ulixertinib^[4].
mitogen-activated protein kinase 1 is part of Protein kinase-like domain superfamily^[5].
mitogen-activated protein kinase 1 is part of mitogen-activated protein (MAP) kinase, ERK1/2^[6].
mitogen-activated protein kinase 1 is part of Protein kinase domain, protein family^[7].
mitogen-activated protein kinase 1 is part of Mitogen-activated protein (MAP) kinase, conserved site, protein family^[8].
mitogen-activated protein kinase 1 is part of Protein kinase, ATP binding site, protein family^[9].
mitogen-activated protein kinase 1 is part of Serine/threonine-protein kinase, active site, protein family^[10].
mitogen-activated protein kinase 1 comprises protein kinase, ATP binding site^[11].
mitogen-activated protein kinase 1 comprises protein kinase domain^[12].
mitogen-activated protein kinase 1 comprises serine/threonine-protein kinase, active site^[13].
mitogen-activated protein kinase 1 comprises mitogen-activated protein (MAP) kinase, conserved site^[14].

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Quick Facts

Instance of protein

Part of Protein kinase-like domain superfamily, mitogen-activated protein (MAP) kinase, ERK1/2, Protein kinase domain, protein family, Mitogen-activated protein (MAP) kinase, conserved site, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process caveolin-mediated endocytosis, positive regulation of telomere capping, response to exogenous dsRNA, cardiac neural crest cell development involved in heart development, positive regulation of translation, cellular response to DNA damage stimulus, platelet activation, Fc-epsilon receptor signaling pathway, protein phosphorylation, face development, cellular response to granulocyte macrophage colony-stimulating factor stimulus, regulation of DNA-binding transcription factor activity, animal organ morphogenesis, cell cycle, ERBB signaling pathway, apoptotic process, B cell receptor signaling pathway, regulation of transcription, DNA-templated, regulation of protein stability, Fc-gamma receptor signaling pathway involved in phagocytosis, thymus development, negative regulation of cell differentiation, ERK1 and ERK2 cascade, labyrinthine layer blood vessel development, transcription, DNA-templated, positive regulation of transcription, DNA-templated, development of the heart, viral process, response to toxic substance, regulation of stress-activated MAPK cascade, chemical synaptic transmission, growth hormone receptor signaling pathway via JAK-STAT, cytosine metabolic process, phosphorylation, outer ear morphogenesis, response to estrogen, chemotaxis, response to lipopolysaccharide, thyroid gland development, response to epidermal growth factor, positive regulation of telomerase activity, sensory perception of pain, peptidyl-threonine phosphorylation, trachea formation, lipopolysaccharide-mediated signaling pathway, mammary gland epithelial cell proliferation, intracellular signal transduction, lung morphogenesis, neural crest cell development, positive regulation of cell migration, regulation of early endosome to late endosome transport, response to stress, positive regulation of telomere maintenance via telomerase, MAPK cascade, axon guidance, fibroblast growth factor receptor signaling pathway, positive regulation of peptidyl-threonine phosphorylation, peptidyl-serine phosphorylation, positive regulation of cell population proliferation, regulation of cellular response to heat, Bergmann glial cell differentiation, regulation of Golgi inheritance, T cell receptor signaling pathway, regulation of cytoskeleton organization, signal transduction, long-term potentiation, regulation of ossification, regulation of phosphatidylinositol 3-kinase signaling, neutrophil degranulation, regulation of gene expression, cellular response to organic substance, protein phosphorylation, ageing, learning or memory, positive regulation of gene expression, diadenosine tetraphosphate biosynthetic process, regulation of cellular pH, cellular response to amino acid starvation, cellular response to reactive oxygen species, response to nicotine, intracellular signal transduction, decidualization, stress-activated MAPK cascade, positive regulation of cardiac muscle cell proliferation, cellular response to cadmium ion, cellular response to tumor necrosis factor, cellular response to dopamine, positive regulation of protein import into nucleus

Cell component cytoplasm, cytosol, focal adhesion, microtubule organizing center, mitochondrion, caveola, dendrite cytoplasm, cytoskeleton, nucleus, extracellular exosome, perikaryon, late endosome, Golgi apparatus, spindle, axon, early endosome, mitotic spindle, pseudopodium, extracellular region, nucleoplasm, azurophil granule lumen, ficolin-1-rich granule lumen, nucleus, cytoplasm, plasma membrane, caveola, postsynaptic density, membrane, protein-containing complex

Ec enzyme number 2.7.11.24

Encoded by MAPK1

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) protein kinase, ATP binding site, protein kinase domain, serine/threonine-protein kinase, active site, mitogen-activated protein (MAP) kinase, conserved site

Molecular function phosphatase binding, ATP binding, protein kinase activity, transcription factor binding, transferase activity, mitogen-activated protein kinase kinase kinase binding, phosphotyrosine residue binding, protein binding, protein kinase binding, DNA binding, nucleotide binding, RNA polymerase II CTD heptapeptide repeat kinase activity, protein serine/threonine kinase activity, kinase activity, identical protein binding, MAP kinase activity, double-stranded DNA binding, MAP kinase kinase activity, phosphatase binding, protein serine/threonine kinase activity

Physically interacts with ravoxertinib, ulixertinib

External References (7)

Ensembl protein id ENSP00000215832, ENSP00000381803, ENSP00000440842

Mesh descriptor id D019950

Mesh tree code D08.811.913.696.620.682.700.567.249.500, D12.776.476.563.567.249.500

Pdb structure id 1PME, 1TVO, 1WZY, 2OJG, 2OJI, 2OJJ, 2Y9Q, 3D42, 3D44, 3I5Z, 3I60, 3SA0, 3TEI, 3W55, 4FMQ, 4FUX, 4FUY, 4FV0, 4FV1, 4FV2, 4FV3, 4FV4, 4FV5, 4FV6, 4FV7, 4FV8, 4FV9, 4G6N, 4G6O, 4H3P, 4H3Q, 4IZ5, 4IZ7, 4IZA, 4N0S, 4NIF, 4O6E, 4QTA, 4QTE, 4ZZM, 4ZZN, 4ZZO, 5BUE, 5BUI, 5BUJ, 4QP1, 4QP2, 4QP3, 4QP4, 4QP6, 4QP7, 4QP8, 4QP9, 4QPA, 4XJ0, 5BVD, 5BVE, 5BVF, 5AX3, 4ZXT, 5K4I

Refseq protein id NP_002736, NP_620407

Umls cui C0170168

Uniprot protein id P28482

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ mitogen-activated protein kinase 1 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ mitogen-activated protein kinase 1 — physically interacts with (P129): ravoxertinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[4] ↑ mitogen-activated protein kinase 1 — physically interacts with (P129): ulixertinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[5] ↑ mitogen-activated protein kinase 1 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ mitogen-activated protein kinase 1 — part of (P361): mitogen-activated protein (MAP) kinase, ERK1/2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ mitogen-activated protein kinase 1 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[8] ↑ mitogen-activated protein kinase 1 — part of (P361): Mitogen-activated protein (MAP) kinase, conserved site, protein family. wikidata.org.
[9] ↑ mitogen-activated protein kinase 1 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[10] ↑ mitogen-activated protein kinase 1 — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[11] ↑ mitogen-activated protein kinase 1 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ mitogen-activated protein kinase 1 — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ mitogen-activated protein kinase 1 — has part(s) (P527): serine/threonine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ mitogen-activated protein kinase 1 — has part(s) (P527): mitogen-activated protein (MAP) kinase, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ mitogen-activated protein kinase 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). mitogen-activated protein kinase 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/mitogen-activated-protein-kinase-1

MLA

“mitogen-activated protein kinase 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/mitogen-activated-protein-kinase-1.

BibTeX

@misc{4ortxyz_mitogen-activated-protein-kinase-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{mitogen-activated protein kinase 1}}, year = {2026}, url = {https://4ort.xyz/entity/mitogen-activated-protein-kinase-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): mitogen-activated protein kinase 1 — https://4ort.xyz/entity/mitogen-activated-protein-kinase-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/mitogen-activated-protein-kinase-1 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → P28482

Umls cui → C0170168

Exact match → https://identifiers.org/uniprot:P28482, http://purl.uniprot.org/uniprot/P28482, https://www.ncbi.nlm.nih.gov/protein/P28482

Imported from → —

+ 17 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.11.24, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"

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