Methyl CpG binding protein 2

mammalian protein found in Rattus norvegicus

Protein protein Q28561868

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Methyl CpG binding protein 2

Summary

Methyl CpG binding protein 2 is a protein^[1].

Key Facts

Methyl CpG binding protein 2's instance of is recorded as protein^[2].
Methyl CpG binding protein 2's subclass of is recorded as protein^[3].
Methyl CpG binding protein 2's UniProt protein ID is recorded as Q00566^[4].
Methyl CpG binding protein 2's part of is recorded as DNA-binding domain superfamily^[5].
Methyl CpG binding protein 2's part of is recorded as methyl-CpG binding protein MeCP2^[6].
Methyl CpG binding protein 2's part of is recorded as Methyl-CpG DNA binding domain, protein family^[7].
Methyl CpG binding protein 2's has part is recorded as methyl-CpG DNA binding^[8].
Methyl CpG binding protein 2's RefSeq protein ID is recorded as NP_073164^[9].
Methyl CpG binding protein 2's RefSeq protein ID is recorded as XP_006229629^[10].
Methyl CpG binding protein 2's RefSeq protein ID is recorded as XP_017457424^[11].
Methyl CpG binding protein 2's RefSeq protein ID is recorded as XP_038955462^[12].
Methyl CpG binding protein 2's molecular function is recorded as four-way junction DNA binding^[13].
Methyl CpG binding protein 2's molecular function is recorded as DNA binding^[14].
Methyl CpG binding protein 2's molecular function is recorded as chromatin binding^[15].
Methyl CpG binding protein 2's molecular function is recorded as protein binding^[16].
Methyl CpG binding protein 2's molecular function is recorded as methyl-CpG binding^[17].
Methyl CpG binding protein 2's molecular function is recorded as double-stranded methylated DNA binding^[18].
Methyl CpG binding protein 2's molecular function is recorded as enzyme binding^[19].
Methyl CpG binding protein 2's molecular function is recorded as protein domain specific binding^[20].
Methyl CpG binding protein 2's molecular function is recorded as chromatin DNA binding^[21].
Methyl CpG binding protein 2's molecular function is recorded as histone deacetylase binding^[22].
Methyl CpG binding protein 2's molecular function is recorded as unmethylated CpG binding^[23].
Methyl CpG binding protein 2's molecular function is recorded as promoter-specific chromatin binding^[24].
Methyl CpG binding protein 2's cell component is recorded as chromatin^[25].
Methyl CpG binding protein 2's cell component is recorded as heterochromatin^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of DNA-binding domain superfamily, methyl-CpG binding protein MeCP2, Methyl-CpG DNA binding domain, protein family

Properties

Biological process negative regulation of transcription by RNA polymerase II, development of the heart, response to radiation, response to ionizing radiation, response to lead ion, positive regulation of gene expression, negative regulation of gene expression, oligodendrocyte development, response to organic cyclic compound, spinal cord development, cerebellum development, principal sensory nucleus of trigeminal nerve development, striatum development, hippocampus development, olfactory bulb development, thalamus development, cerebral cortex development, neuron differentiation, positive regulation of synaptic plasticity, negative regulation of protein binding, response to estradiol, social behavior, cellular response to potassium ion, response to cocaine, regulation of DNA methylation, negative regulation of transcription, DNA-templated, lung alveolus development, oligodendrocyte differentiation, negative regulation of astrocyte differentiation, regulation of synapse organization, positive regulation of dendritic spine development, negative regulation of dendritic spine development, cellular response to isoquinoline alkaloid, positive regulation of anterograde dense core granule transport, positive regulation of retrograde dense core granule transport, negative regulation of dendrite extension, positive regulation of dendrite extension, positive regulation of branching morphogenesis of a nerve, negative regulation of primary miRNA processing

Cell component chromatin, heterochromatin, nucleus, nucleoplasm, cytosol, protein-containing complex, glutamatergic synapse

Encoded by Mecp2

Found in taxon brown rat

Has part(s) methyl-CpG DNA binding

Imported from wholeness_audit_2026-05-02

Molecular function four-way junction DNA binding, DNA binding, chromatin binding, protein binding, methyl-CpG binding, double-stranded methylated DNA binding, enzyme binding, protein domain specific binding, chromatin DNA binding, histone deacetylase binding, unmethylated CpG binding, promoter-specific chromatin binding

External References (3)

Ensembl protein id ENSRNOP00000069913

Refseq protein id NP_073164, XP_006229629, XP_017457424, XP_038955462

Uniprot protein id Q00566

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Methyl CpG binding protein 2 — instance of (P31): protein. Q905695. Retrieved 2021-11-17. wikidata.org.
[3] ↑ Methyl CpG binding protein 2 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Methyl CpG binding protein 2 — UniProt protein ID (P352): Q00566. Q905695. Retrieved 2021-11-17. wikidata.org.
[5] ↑ Methyl CpG binding protein 2 — part of (P361): DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Methyl CpG binding protein 2 — part of (P361): methyl-CpG binding protein MeCP2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Methyl CpG binding protein 2 — part of (P361): Methyl-CpG DNA binding domain, protein family. wikidata.org.
[8] ↑ Methyl CpG binding protein 2 — has part(s) (P527): methyl-CpG DNA binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Methyl CpG binding protein 2 — RefSeq protein ID (P637): NP_073164. Q20641742. Retrieved 2021-09-07. wikidata.org.
[10] ↑ Methyl CpG binding protein 2 — RefSeq protein ID (P637): XP_006229629. Q20641742. Retrieved 2021-09-07. wikidata.org.
[11] ↑ Methyl CpG binding protein 2 — RefSeq protein ID (P637): XP_017457424. Q20641742. Retrieved 2021-09-07. wikidata.org.
[12] ↑ Methyl CpG binding protein 2 — RefSeq protein ID (P637): XP_038955462. Q20641742. Retrieved 2021-09-07. wikidata.org.
[13] ↑ Methyl CpG binding protein 2 — molecular function (P680): four-way junction DNA binding. Structure-specific binding of MeCP2 to four-way junction DNA through its methyl CpG-binding domain. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Methyl CpG binding protein 2 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Methyl CpG binding protein 2 — molecular function (P680): chromatin binding. Cocaine represses protein phosphatase-1Cβ through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Methyl CpG binding protein 2 — molecular function (P680): protein binding. A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Methyl CpG binding protein 2 — molecular function (P680): methyl-CpG binding. Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Methyl CpG binding protein 2 — molecular function (P680): double-stranded methylated DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Methyl CpG binding protein 2 — molecular function (P680): enzyme binding. Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Methyl CpG binding protein 2 — molecular function (P680): protein domain specific binding. MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Methyl CpG binding protein 2 — molecular function (P680): chromatin DNA binding. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Methyl CpG binding protein 2 — molecular function (P680): histone deacetylase binding. Dexamethasone Induces a Putative Repressor Complex and Chromatin Modifications in the CRH Promoter. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Methyl CpG binding protein 2 — molecular function (P680): unmethylated CpG binding. Structure-specific binding of MeCP2 to four-way junction DNA through its methyl CpG-binding domain. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Methyl CpG binding protein 2 — molecular function (P680): promoter-specific chromatin binding. IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPARγ gene in male and female rat lungs during alveolarization. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Methyl CpG binding protein 2 — cell component (P681): chromatin. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Methyl CpG binding protein 2 — cell component (P681): heterochromatin. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Methyl CpG binding protein 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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MLA

“Methyl CpG binding protein 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/methyl-cpg-binding-protein-2-q28561868.

BibTeX

@misc{4ortxyz_methyl-cpg-binding-protein-2-q28561868_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Methyl CpG binding protein 2}}, year = {2026}, url = {https://4ort.xyz/entity/methyl-cpg-binding-protein-2-q28561868}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Methyl CpG binding protein 2 — https://4ort.xyz/entity/methyl-cpg-binding-protein-2-q28561868 (retrieved 2026-05-03)

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