Methenyltetrahydrofolate synthetase

mammalian protein found in Homo sapiens
Protein protein Q22677530
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Summary

Methenyltetrahydrofolate synthetase is a protein[1]. It is known by 6 alternative names across languages and contexts.[2]

Key Facts

  • Subclass of: protein[3]
  • Part of: NagB/RpiA transferase-like[4], 5-formyltetrahydrofolate cyclo-ligase[5], 5-formyltetrahydrofolate cyclo-ligase-like domain superfamily[6]
  • Molecular function: folic acid binding[7], ligase activity[8], ATP binding[9], metal ion binding[10], nucleotide binding[11], 5-formyltetrahydrofolate cyclo-ligase activity[12]
  • Cell component: mitochondrial matrix[13], cytoplasm[14], cytosol[15], mitochondrion[16]
  • Biological process: tetrahydrofolate metabolic process[17], glutamate metabolic process[18], formate metabolic process[19], folic acid-containing compound biosynthetic process[20], tetrahydrofolate interconversion[21], folic acid catabolic process[22], folic acid metabolic process[23]
  • Encoded by: MTHFS[24]
  • Found in taxon: Homo sapiens[25]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . UniProt. Retrieved . wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [7] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . Identification and characterization of human mitochondrial methenyltetrahydrofolate synthetase activity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . Cloning and characterization of the human 5,10-methenyltetrahydrofolate synthetase-encoding cDNA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . UniProt. Retrieved . wikidata.org.
  23. [25] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Methenyltetrahydrofolate synthetase. Retrieved May 3, 2026, from https://4ort.xyz/entity/methenyltetrahydrofolate-synthetase
MLA “Methenyltetrahydrofolate synthetase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/methenyltetrahydrofolate-synthetase.
BibTeX @misc{4ortxyz_methenyltetrahydrofolate-synthetase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Methenyltetrahydrofolate synthetase}}, year = {2026}, url = {https://4ort.xyz/entity/methenyltetrahydrofolate-synthetase}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 11w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Subclass of → protein
    Wikidata description → mammalian protein found in Homo sapiens
    Encoded by → MTHFS
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 6.3.3.2, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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