MDM2 proto-oncogene

mammalian protein found in Homo sapiens

Protein protein Q2639180

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MDM2 proto-oncogene

Summary

MDM2 proto-oncogene is a protein^[1].

Key Facts

MDM2 proto-oncogene's instance of is recorded as protein^[2].
MDM2 proto-oncogene is part of Zinc finger, RanBP2-type superfamily^[3].
MDM2 proto-oncogene is part of E3 ubiquitin-protein ligase Mdm2^[4].
MDM2 proto-oncogene is part of Zinc finger, RING/FYVE/PHD-type^[5].
MDM2 proto-oncogene is part of SWIB/MDM2 domain superfamily^[6].
MDM2 proto-oncogene is part of Ubiquitin-protein ligase E3 MDM2^[7].
MDM2 proto-oncogene is part of Zinc finger, RING-type, protein family^[8].
MDM2 proto-oncogene is part of SWIB/MDM2 domain, protein family^[9].
MDM2 proto-oncogene is part of Zinc finger, RanBP2-type, protein family^[10].
MDM2 proto-oncogene comprises Zinc finger, RanBP2-type^[11].
MDM2 proto-oncogene comprises SWIB/MDM2 domain^[12].
MDM2 proto-oncogene comprises Zinc finger, RING-type^[13].

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Quick Facts

Instance of protein

Part of Zinc finger, RanBP2-type superfamily, E3 ubiquitin-protein ligase Mdm2, Zinc finger, RING/FYVE/PHD-type, SWIB/MDM2 domain superfamily, Ubiquitin-protein ligase E3 MDM2, Zinc finger, RING-type, protein family, SWIB/MDM2 domain, protein family, Zinc finger, RanBP2-type, protein family

Properties

Biological process negative regulation of signal transduction by p53 class mediator, endocardial cushion morphogenesis, cellular response to UV-C, atrial septum development, regulation of heart rate, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, positive regulation of gene expression, blood vessel development, positive regulation of cell population proliferation, negative regulation of DNA damage response, signal transduction by p53 class mediator, response to ether, blood vessel remodeling, cellular response to hypoxia, heart valve development, cellular response to estrogen stimulus, negative regulation of apoptotic process, cellular response to organic substance, cellular response to hydrogen peroxide, response to cocaine, cardiac septum morphogenesis, negative regulation of transcription by RNA polymerase II, peptidyl-lysine modification, positive regulation of cell cycle, ventricular septum development, positive regulation of protein export from nucleus, response to steroid hormone, cellular response to growth factor stimulus, regulation of protein catabolic process, cellular response to antibiotic, negative regulation of gene expression, positive regulation of mitotic cell cycle, development of the heart, cellular response to alkaloid, cellular response to vitamin B1, response to magnesium ion, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, cellular response to peptide hormone stimulus, cellular response to organic cyclic compound, viral process, response to iron ion, regulation of gene expression, response to antibiotic, traversing start control point of mitotic cell cycle, protein ubiquitination, negative regulation of protein processing, establishment of protein localization, response to toxic substance, response to morphine, atrioventricular valve morphogenesis, protein localization to nucleus, regulation of signal transduction by p53 class mediator, positive regulation of vascular associated smooth muscle cell proliferation, response to water-immersion restraint stress, negative regulation of neuron projection development, positive regulation of vascular associated smooth muscle cell migration, protein deubiquitination, protein sumoylation, transcription factor catabolic process, protein autoubiquitination, response to formaldehyde, protein destabilization, negative regulation of transcription, DNA-templated, proteolysis involved in cellular protein catabolic process, cellular response to gamma radiation, cellular response to actinomycin D, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, amyloid fibril formation, protein-containing complex assembly, ubiquitin-dependent protein catabolic process

Cell component cytosol, endocytic vesicle membrane, plasma membrane, synapse, nuclear body, cytoplasm, nucleus, nucleoplasm, nucleolus, protein-containing complex

Ec enzyme number 2.3.2.27

Encoded by MDM2

Found in taxon Homo sapiens

Has part(s) Zinc finger, RanBP2-type, SWIB/MDM2 domain, Zinc finger, RING-type

Molecular function scaffold protein binding, protein binding, enzyme binding, metal ion binding, identical protein binding, ubiquitin protein ligase binding, p53 binding, SUMO transferase activity, ubiquitin-protein transferase activity, transferase activity, ligase activity, 5S rRNA binding, zinc ion binding, ribonucleoprotein complex binding, protein N-terminus binding, ubiquitin protein ligase activity, NEDD8 ligase activity, disordered domain specific binding, protein domain specific binding, receptor serine/threonine kinase binding, peroxisome proliferator activated receptor binding, ubiquitin binding, ubiquitin protein ligase activity

External References (5)

Ensembl protein id ENSP00000258149, ENSP00000299252, ENSP00000353611, ENSP00000377065, ENSP00000258148, ENSP00000266624, ENSP00000310742, ENSP00000335096, ENSP00000377062, ENSP00000377064, ENSP00000377067, ENSP00000377068, ENSP00000410694, ENSP00000427828, ENSP00000429021, ENSP00000429692, ENSP00000430257, ENSP00000430906, ENSP00000431110, ENSP00000439238, ENSP00000441841, ENSP00000443450, ENSP00000444028, ENSP00000444430, ENSP00000444566, ENSP00000444597, ENSP00000445030, ENSP00000445222, ENSP00000499407, ENSP00000499763, ENSP00000499718

Freebase id /m/09xvjd

Pdb structure id 1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS, 3G03, 3IUX, 3IWY, 3JZK, 3JZR, 3JZS, 3LBK, 3LBL, 3LNJ, 3LNZ, 3MQS, 3TJ2, 3TPX, 3TU1, 3V3B, 3VBG, 3VZV, 3W69, 4DIJ, 4ERE, 4ERF, 4HBM, 4HFZ, 4HG7, 4JV7, 4JV9, 4JVE, 4JVR, 4JWR, 4MDN, 4MDQ, 4OAS, 4OBA, 4OCC, 4ODE, 4ODF, 4OGN, 4OGT, 4OGV, 4OQ3, 4QO4, 4QOC, 4UMN, 4WT2, 4XXB, 4ZYC, 4ZYF, 4ZYI, 4UE1, 4UD7, 5AFG, 5HMI, 5HMK, 5HMH, 5C5A

Refseq protein id NP_001138809, NP_001138811, NP_001138812, NP_001265391, NP_002383, XP_006719462, XP_006719463, NP_001354919

Uniprot protein id Q00987

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ MDM2 proto-oncogene — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ MDM2 proto-oncogene — part of (P361): Zinc finger, RanBP2-type superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ MDM2 proto-oncogene — part of (P361): E3 ubiquitin-protein ligase Mdm2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ MDM2 proto-oncogene — part of (P361): Zinc finger, RING/FYVE/PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ MDM2 proto-oncogene — part of (P361): SWIB/MDM2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ MDM2 proto-oncogene — part of (P361): Ubiquitin-protein ligase E3 MDM2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ MDM2 proto-oncogene — part of (P361): Zinc finger, RING-type, protein family. wikidata.org.
[9] ↑ MDM2 proto-oncogene — part of (P361): SWIB/MDM2 domain, protein family. wikidata.org.
[10] ↑ MDM2 proto-oncogene — part of (P361): Zinc finger, RanBP2-type, protein family. wikidata.org.
[11] ↑ MDM2 proto-oncogene — has part(s) (P527): Zinc finger, RanBP2-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ MDM2 proto-oncogene — has part(s) (P527): SWIB/MDM2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ MDM2 proto-oncogene — has part(s) (P527): Zinc finger, RING-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ MDM2 proto-oncogene is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). MDM2 proto-oncogene. Retrieved May 3, 2026, from https://4ort.xyz/entity/mdm2-proto-oncogene

MLA “MDM2 proto-oncogene.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/mdm2-proto-oncogene.

BibTeX

@misc{4ortxyz_mdm2-proto-oncogene_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{MDM2 proto-oncogene}}, year = {2026}, url = {https://4ort.xyz/entity/mdm2-proto-oncogene}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): MDM2 proto-oncogene — https://4ort.xyz/entity/mdm2-proto-oncogene (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/mdm2-proto-oncogene · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → Q00987

Ec enzyme number → 2.3.2.27

Refseq protein id → NP_001138809, NP_001138811, NP_001138812 +5

Imported from → —

+ 12 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.3.2.27, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"

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