Major prion protein

human protein (annotated by UniProtKB/Swiss-Prot P04156)

Protein protein Q21096129

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Major prion protein

Summary

Major prion protein is a protein^[1].

Key Facts

Major prion protein's instance of is recorded as protein^[2].
Major prion protein's UniProt protein ID is recorded as P04156^[3].
Major prion protein's part of is recorded as prion protein family^[4].
Major prion protein's part of is recorded as Prion/Doppel beta-ribbon domain superfamily^[5].
Major prion protein's part of is recorded as Prion/Doppel protein, beta-ribbon domain, protein family^[6].
Major prion protein's part of is recorded as Major prion protein N-terminal domain, protein family^[7].
Major prion protein's has part is recorded as Major prion protein N-terminal domain^[8].
Major prion protein's has part is recorded as Prion/Doppel protein, beta-ribbon domain^[9].
Major prion protein's RefSeq protein ID is recorded as NP_000302.1^[10].
Major prion protein's RefSeq protein ID is recorded as NP_001073590.1^[11].
Major prion protein's RefSeq protein ID is recorded as NP_001073591.1^[12].
Major prion protein's RefSeq protein ID is recorded as NP_001073592.1^[13].
Major prion protein's RefSeq protein ID is recorded as NP_898902.1^[14].
Major prion protein's PDB structure ID is recorded as 1E1G^[15].
Major prion protein's PDB structure ID is recorded as 1E1J^[16].
Major prion protein's PDB structure ID is recorded as 1E1P^[17].
Major prion protein's PDB structure ID is recorded as 1E1S^[18].
Major prion protein's PDB structure ID is recorded as 1E1U^[19].
Major prion protein's PDB structure ID is recorded as 1E1W^[20].
Major prion protein's PDB structure ID is recorded as 1FKC^[21].
Major prion protein's PDB structure ID is recorded as 1FO7^[22].
Major prion protein's PDB structure ID is recorded as 1H0L^[23].
Major prion protein's PDB structure ID is recorded as 1HJM^[24].
Major prion protein's PDB structure ID is recorded as 1HJN^[25].
Major prion protein's PDB structure ID is recorded as 1I4M^[26].

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Quick Facts

Instance of protein

Part of prion protein family, Prion/Doppel beta-ribbon domain superfamily, Prion/Doppel protein, beta-ribbon domain, protein family, Major prion protein N-terminal domain, protein family

Properties

Biological process negative regulation of protein phosphorylation, negative regulation of interferon-gamma production, response to cadmium ion, negative regulation of calcineurin-NFAT signaling cascade, response to copper ion, negative regulation of apoptotic process, response to oxidative stress, negative regulation of DNA-binding transcription factor activity, negative regulation of T cell receptor signaling pathway, regulation of protein localization, negative regulation of activated T cell proliferation, learning or memory, cellular copper ion homeostasis, cellular response to copper ion, cell cycle, metabolism, negative regulation of interleukin-17 production, protein homooligomerization, negative regulation of interleukin-2 production, regulation of potassium ion transmembrane transport, response to oxidative stress, learning or memory, long-term memory, positive regulation of cell death, negative regulation of protein processing, protein destabilization, activation of protein kinase activity, calcium-mediated signaling using intracellular calcium source, negative regulation of apoptotic process, negative regulation of catalytic activity, positive regulation of neuron apoptotic process, response to cadmium ion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, protein homooligomerization, positive regulation of protein tyrosine kinase activity, positive regulation of protein targeting to membrane, dendritic spine maintenance, negative regulation of long-term synaptic potentiation, regulation of glutamate receptor signaling pathway, positive regulation of neuron death, negative regulation of amyloid-beta formation, regulation of intracellular calcium activated chloride channel activity, negative regulation of dendritic spine maintenance, negative regulation of amyloid precursor protein catabolic process, positive regulation of protein localization to plasma membrane, response to amyloid-beta, cellular response to amyloid-beta, regulation of calcium ion import across plasma membrane, neuron projection maintenance

Cell component cytoplasm, Golgi apparatus, membrane, plasma membrane, cell surface, endoplasmic reticulum, membrane raft, anchored component of membrane, extracellular exosome, nucleus, extrinsic component of membrane, cytoplasm, cytosol, plasma membrane, cell surface, postsynaptic density, inclusion body, dendrite, anchored component of external side of plasma membrane, nuclear membrane, intracellular membrane-bounded organelle, membrane raft, extracellular exosome, postsynapse

Encoded by PRNP

Found in taxon Homo sapiens

Has part(s) Major prion protein N-terminal domain, Prion/Doppel protein, beta-ribbon domain

Imported from wholeness_audit_2026-05-02

Molecular function chaperone binding, transmembrane transporter binding, microtubule binding, ATP-dependent protein binding, metal ion binding, tubulin binding, protein binding, identical protein binding, copper ion binding, lamin binding, amyloid-beta binding, protease binding, protein binding, lamin binding, glycosaminoglycan binding, microtubule binding, type 5 metabotropic glutamate receptor binding, type 8 metabotropic glutamate receptor binding, signaling receptor activity, identical protein binding, ATP-dependent protein binding, transmembrane transporter binding, protein-containing complex binding, chaperone binding, cupric ion binding, cuprous ion binding

External References (4)

Pdb structure id 1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1, 1QM2, 1QM3, 2IV4, 2IV5, 2IV6, 2K1D, 2KUN, 2LBG, 2LEJ, 2LFT, 2LSB, 2LV1, 2M8T, 2W9E, 3HAF, 3HAK, 3HEQ, 3HER, 3HES, 3HJ5, 3HJX, 3MD4, 3MD5, 3NHC, 3NVF, 4DGI, 4E1H, 4E1I, 4KML, 4N9O

Refseq protein id NP_000302.1, NP_001073590.1, NP_001073591.1, NP_001073592.1, NP_898902.1

Transporter classification database id 1.C.48.1.2

Uniprot protein id P04156

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Major prion protein — instance of (P31): protein. wikidata.org.
[3] ↑ Major prion protein — UniProt protein ID (P352): P04156. Q905695. Retrieved 2016-08-04. wikidata.org.
[4] ↑ Major prion protein — part of (P361): prion protein family. InterPro Release 71.0. Retrieved 2019-10-02. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Major prion protein — part of (P361): Prion/Doppel beta-ribbon domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Major prion protein — part of (P361): Prion/Doppel protein, beta-ribbon domain, protein family. wikidata.org.
[7] ↑ Major prion protein — part of (P361): Major prion protein N-terminal domain, protein family. wikidata.org.
[8] ↑ Major prion protein — has part(s) (P527): Major prion protein N-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Major prion protein — has part(s) (P527): Prion/Doppel protein, beta-ribbon domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Major prion protein — RefSeq protein ID (P637): NP_000302.1. Q905695. Retrieved 2016-08-04. wikidata.org.
[11] ↑ Major prion protein — RefSeq protein ID (P637): NP_001073590.1. Q905695. Retrieved 2016-08-04. wikidata.org.
[12] ↑ Major prion protein — RefSeq protein ID (P637): NP_001073591.1. Q905695. Retrieved 2016-08-04. wikidata.org.
[13] ↑ Major prion protein — RefSeq protein ID (P637): NP_001073592.1. Q905695. Retrieved 2016-08-04. wikidata.org.
[14] ↑ Major prion protein — RefSeq protein ID (P637): NP_898902.1. Q905695. Retrieved 2016-08-04. wikidata.org.
[15] ↑ Major prion protein — PDB structure ID (P638): 1E1G. Q905695. Retrieved 2016-08-04. wikidata.org.
[16] ↑ Major prion protein — PDB structure ID (P638): 1E1J. Q905695. Retrieved 2016-08-04. wikidata.org.
[17] ↑ Major prion protein — PDB structure ID (P638): 1E1P. Q905695. Retrieved 2016-08-04. wikidata.org.
[18] ↑ Major prion protein — PDB structure ID (P638): 1E1S. Q905695. Retrieved 2016-08-04. wikidata.org.
[19] ↑ Major prion protein — PDB structure ID (P638): 1E1U. Q905695. Retrieved 2016-08-04. wikidata.org.
[20] ↑ Major prion protein — PDB structure ID (P638): 1E1W. Q905695. Retrieved 2016-08-04. wikidata.org.
[21] ↑ Major prion protein — PDB structure ID (P638): 1FKC. Q905695. Retrieved 2016-08-04. wikidata.org.
[22] ↑ Major prion protein — PDB structure ID (P638): 1FO7. Q905695. Retrieved 2016-08-04. wikidata.org.
[23] ↑ Major prion protein — PDB structure ID (P638): 1H0L. Q905695. Retrieved 2016-08-04. wikidata.org.
[24] ↑ Major prion protein — PDB structure ID (P638): 1HJM. Q905695. Retrieved 2016-08-04. wikidata.org.
[25] ↑ Major prion protein — PDB structure ID (P638): 1HJN. Q905695. Retrieved 2016-08-04. wikidata.org.
[26] ↑ Major prion protein — PDB structure ID (P638): 1I4M. Q905695. Retrieved 2016-08-04. wikidata.org.

Class ancestry

[1] ↑ Major prion protein is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Major prion protein. Retrieved May 3, 2026, from https://4ort.xyz/entity/major-prion-protein

MLA “Major prion protein.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/major-prion-protein.

BibTeX

@misc{4ortxyz_major-prion-protein_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Major prion protein}}, year = {2026}, url = {https://4ort.xyz/entity/major-prion-protein}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Major prion protein — https://4ort.xyz/entity/major-prion-protein (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/major-prion-protein · Last refreshed: May 3, 2026