Lysine (K)-specific demethylase 4A

mammalian protein found in Mus musculus

Protein protein Q21987129

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Summary

Lysine (K)-specific demethylase 4A is a protein^[1].

Key Facts

Lysine (K)-specific demethylase 4A's instance of is recorded as protein^[2].
Lysine (K)-specific demethylase 4A's subclass of is recorded as protein^[3].
Lysine (K)-specific demethylase 4A's UniProt protein ID is recorded as Q8BW72^[4].
Lysine (K)-specific demethylase 4A's part of is recorded as Zinc finger, FYVE/PHD-type^[5].
Lysine (K)-specific demethylase 4A's part of is recorded as Zinc finger, RING/FYVE/PHD-type^[6].
Lysine (K)-specific demethylase 4A's part of is recorded as JmjC domain, protein family^[7].
Lysine (K)-specific demethylase 4A's part of is recorded as JmjN domain, protein family^[8].
Lysine (K)-specific demethylase 4A's part of is recorded as Tudor domain, protein family^[9].
Lysine (K)-specific demethylase 4A's part of is recorded as Zinc finger, PHD-type, protein family^[10].
Lysine (K)-specific demethylase 4A's part of is recorded as Extended PHD (ePHD) domain, protein family^[11].
Lysine (K)-specific demethylase 4A's has part is recorded as Tudor domain^[12].
Lysine (K)-specific demethylase 4A's has part is recorded as Zinc finger, PHD-type^[13].
Lysine (K)-specific demethylase 4A's has part is recorded as JmjC domain^[14].
Lysine (K)-specific demethylase 4A's has part is recorded as JmjN domain^[15].
Lysine (K)-specific demethylase 4A's has part is recorded as Extended PHD (ePHD) domain^[16].
Lysine (K)-specific demethylase 4A's RefSeq protein ID is recorded as NP_001155295^[17].
Lysine (K)-specific demethylase 4A's RefSeq protein ID is recorded as NP_759014^[18].
Lysine (K)-specific demethylase 4A's RefSeq protein ID is recorded as XP_006503073^[19].
Lysine (K)-specific demethylase 4A's molecular function is recorded as dioxygenase activity^[20].
Lysine (K)-specific demethylase 4A's molecular function is recorded as metal ion binding^[21].
Lysine (K)-specific demethylase 4A's molecular function is recorded as histone demethylase activity^[22].
Lysine (K)-specific demethylase 4A's molecular function is recorded as oxidoreductase activity^[23].
Lysine (K)-specific demethylase 4A's molecular function is recorded as zinc ion binding^[24].
Lysine (K)-specific demethylase 4A's molecular function is recorded as ubiquitin protein ligase binding^[25].
Lysine (K)-specific demethylase 4A's molecular function is recorded as histone H3-methyl-lysine-9 demethylase activity^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Zinc finger, FYVE/PHD-type, Zinc finger, RING/FYVE/PHD-type, JmjC domain, protein family, JmjN domain, protein family, Tudor domain, protein family, Zinc finger, PHD-type, protein family, Extended PHD (ePHD) domain, protein family

Properties

Biological process regulation of transcription, DNA-templated, transcription, DNA-templated, cardiac muscle hypertrophy in response to stress, negative regulation of histone H3-K9 trimethylation, response to nutrient levels, chromatin organization, negative regulation of autophagy, positive regulation of gene expression, negative regulation of gene expression, histone demethylation, histone H3-K9 demethylation, positive regulation of neuron differentiation, negative regulation of transcription, DNA-templated, negative regulation of astrocyte differentiation, negative regulation of cell death, histone H3-K36 demethylation, negative regulation of transcription by RNA polymerase II, negative regulation of autophagy, negative regulation of gene expression, histone demethylation, histone H3-K9 demethylation, negative regulation of transcription, DNA-templated, histone H3-K36 demethylation, chromatin remodeling

Cell component pericentric heterochromatin, nucleus, fibrillar center, cytoplasm, cytosol, fibrillar center, nucleus, cytosol, histone methyltransferase complex

Encoded by Kdm4a

Found in taxon house mouse

Has part(s) Tudor domain, Zinc finger, PHD-type, JmjC domain, JmjN domain, Extended PHD (ePHD) domain

Imported from wholeness_audit_2026-05-02

Molecular function dioxygenase activity, metal ion binding, histone demethylase activity, oxidoreductase activity, zinc ion binding, ubiquitin protein ligase binding, histone H3-methyl-lysine-9 demethylase activity, methylated histone binding, histone H3-methyl-lysine-36 demethylase activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, chromatin binding, zinc ion binding, ubiquitin protein ligase binding, histone demethylase activity, histone H3-methyl-lysine-9 demethylase activity, methylated histone binding, histone H3-methyl-lysine-36 demethylase activity, methylated histone binding, histone H3-methyl-lysine-36 demethylase activity

External References (3)

Ensembl protein id ENSMUSP00000095524, ENSMUSP00000102011, ENSMUSP00000102014, ENSMUSP00000062910

Refseq protein id NP_001155295, NP_759014, XP_006503073

Uniprot protein id Q8BW72

🏷️ Also known as

en [histone H3]-trimethyl-L-lysine(36) demethylase 4A en [histone H3]-trimethyl-L-lysine(9) demethylase 4A en jmjC domain-containing histone demethylation protein 3A en jumonji domain containing 2A en jumonji domain-containing protein 2A en Kdm4a en Lysine (K)-specific demethylase 4A en lysine-specific demethylase 4A nl Lysine

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Lysine (K)-specific demethylase 4A — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Lysine (K)-specific demethylase 4A — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Lysine (K)-specific demethylase 4A — UniProt protein ID (P352): Q8BW72. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Lysine (K)-specific demethylase 4A — part of (P361): Zinc finger, FYVE/PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Lysine (K)-specific demethylase 4A — part of (P361): Zinc finger, RING/FYVE/PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Lysine (K)-specific demethylase 4A — part of (P361): JmjC domain, protein family. wikidata.org.
[8] ↑ Lysine (K)-specific demethylase 4A — part of (P361): JmjN domain, protein family. wikidata.org.
[9] ↑ Lysine (K)-specific demethylase 4A — part of (P361): Tudor domain, protein family. wikidata.org.
[10] ↑ Lysine (K)-specific demethylase 4A — part of (P361): Zinc finger, PHD-type, protein family. wikidata.org.
[11] ↑ Lysine (K)-specific demethylase 4A — part of (P361): Extended PHD (ePHD) domain, protein family. wikidata.org.
[12] ↑ Lysine (K)-specific demethylase 4A — has part(s) (P527): Tudor domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Lysine (K)-specific demethylase 4A — has part(s) (P527): Zinc finger, PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Lysine (K)-specific demethylase 4A — has part(s) (P527): JmjC domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Lysine (K)-specific demethylase 4A — has part(s) (P527): JmjN domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Lysine (K)-specific demethylase 4A — has part(s) (P527): Extended PHD (ePHD) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Lysine (K)-specific demethylase 4A — RefSeq protein ID (P637): NP_001155295. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Lysine (K)-specific demethylase 4A — RefSeq protein ID (P637): NP_759014. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Lysine (K)-specific demethylase 4A — RefSeq protein ID (P637): XP_006503073. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Lysine (K)-specific demethylase 4A — molecular function (P680): dioxygenase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Lysine (K)-specific demethylase 4A — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Lysine (K)-specific demethylase 4A — molecular function (P680): histone demethylase activity. Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Lysine (K)-specific demethylase 4A — molecular function (P680): oxidoreductase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Lysine (K)-specific demethylase 4A — molecular function (P680): zinc ion binding. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Lysine (K)-specific demethylase 4A — molecular function (P680): ubiquitin protein ligase binding. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Lysine (K)-specific demethylase 4A — molecular function (P680): histone H3-methyl-lysine-9 demethylase activity. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Lysine (K)-specific demethylase 4A is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

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MLA

“Lysine (K)-specific demethylase 4A.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/lysine-k-specific-demethylase-4a.

BibTeX

@misc{4ortxyz_lysine-k-specific-demethylase-4a_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Lysine (K)-specific demethylase 4A}}, year = {2026}, url = {https://4ort.xyz/entity/lysine-k-specific-demethylase-4a}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Lysine (K)-specific demethylase 4A — https://4ort.xyz/entity/lysine-k-specific-demethylase-4a (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/lysine-k-specific-demethylase-4a · Last refreshed: May 3, 2026