Lysine (K)-specific demethylase 1A

mammalian protein found in Mus musculus

Protein protein Q21987128

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Lysine (K)-specific demethylase 1A

Summary

Lysine (K)-specific demethylase 1A is a protein^[1].

Key Facts

Lysine (K)-specific demethylase 1A's instance of is recorded as protein^[2].
Lysine (K)-specific demethylase 1A's subclass of is recorded as protein^[3].
Lysine (K)-specific demethylase 1A's UniProt protein ID is recorded as Q6ZQ88^[4].
Lysine (K)-specific demethylase 1A's part of is recorded as Histone lysine-specific demethylase^[5].
Lysine (K)-specific demethylase 1A's part of is recorded as Winged helix-like DNA-binding domain superfamily^[6].
Lysine (K)-specific demethylase 1A's part of is recorded as Homeobox-like domain superfamily^[7].
Lysine (K)-specific demethylase 1A's part of is recorded as FAD/NAD(P)-binding domain superfamily^[8].
Lysine (K)-specific demethylase 1A's part of is recorded as SWIRM domain, protein family^[9].
Lysine (K)-specific demethylase 1A's part of is recorded as Amine oxidase domain, protein family^[10].
Lysine (K)-specific demethylase 1A's has part is recorded as SWIRM domain^[11].
Lysine (K)-specific demethylase 1A's has part is recorded as Amine oxidase domain^[12].
Lysine (K)-specific demethylase 1A's RefSeq protein ID is recorded as NP_001334150^[13].
Lysine (K)-specific demethylase 1A's RefSeq protein ID is recorded as NP_598633^[14].
Lysine (K)-specific demethylase 1A's RefSeq protein ID is recorded as XP_006539392^[15].
Lysine (K)-specific demethylase 1A's RefSeq protein ID is recorded as NP_001343496^[16].
Lysine (K)-specific demethylase 1A's molecular function is recorded as DNA-binding transcription factor activity^[17].
Lysine (K)-specific demethylase 1A's molecular function is recorded as DNA binding^[18].
Lysine (K)-specific demethylase 1A's molecular function is recorded as protein binding^[19].
Lysine (K)-specific demethylase 1A's molecular function is recorded as flavin adenine dinucleotide binding^[20].
Lysine (K)-specific demethylase 1A's molecular function is recorded as oxidoreductase activity^[21].
Lysine (K)-specific demethylase 1A's molecular function is recorded as p53 binding^[22].
Lysine (K)-specific demethylase 1A's molecular function is recorded as chromatin binding^[23].
Lysine (K)-specific demethylase 1A's molecular function is recorded as transcription factor binding^[24].
Lysine (K)-specific demethylase 1A's molecular function is recorded as enzyme binding^[25].
Lysine (K)-specific demethylase 1A's molecular function is recorded as nuclear receptor coactivator activity^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Histone lysine-specific demethylase, Winged helix-like DNA-binding domain superfamily, Homeobox-like domain superfamily, FAD/NAD(P)-binding domain superfamily, SWIRM domain, protein family, Amine oxidase domain, protein family

Properties

Biological process positive regulation of stem cell proliferation, negative regulation of histone H3-K4 methylation, muscle cell development, regulation of primitive erythrocyte differentiation, transcription, DNA-templated, multicellular organism development, negative regulation of histone H3-K9 methylation, granulocyte differentiation, pituitary gland development, positive regulation of neural precursor cell proliferation, positive regulation of hormone biosynthetic process, in utero embryonic development, positive regulation of erythrocyte differentiation, positive regulation of megakaryocyte differentiation, regulation of transcription, DNA-templated, cell population proliferation, histone H3-K4 demethylation, neuron projection extension, negative regulation of neurogenesis, regulation of neurogenesis, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, protein demethylation, regulation of double-strand break repair via homologous recombination, negative regulation of protein binding, histone H3-K9 demethylation, positive regulation of histone ubiquitination, cellular response to UV, negative regulation of DNA-binding transcription factor activity, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, positive regulation of DNA-binding transcription factor activity, cellular response to gamma radiation, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, chromatin organization, positive regulation of neuron projection development, positive regulation of chromatin binding, positive regulation of cell size, guanine metabolic process, negative regulation of transcription by RNA polymerase II, positive regulation of neuroblast proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of cold-induced thermogenesis

Cell component transcription regulator complex, nucleus, nucleoplasm, DNA repair complex, protein-containing complex, nucleus

Encoded by Kdm1a

Found in taxon house mouse

Has part(s) SWIRM domain, Amine oxidase domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA-binding transcription factor activity, DNA binding, protein binding, flavin adenine dinucleotide binding, oxidoreductase activity, p53 binding, chromatin binding, transcription factor binding, enzyme binding, nuclear receptor coactivator activity, demethylase activity, histone demethylase activity, histone H3-methyl-lysine-4 demethylase activity, histone H3-methyl-lysine-9 demethylase activity, telomeric DNA binding, MRF binding, androgen receptor binding, telomeric repeat-containing RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, transcription factor binding, oxidoreductase activity, flavin adenine dinucleotide binding

External References (3)

Ensembl protein id ENSMUSP00000111977, ENSMUSP00000035457, ENSMUSP00000101473, ENSMUSP00000114268, ENSMUSP00000131385

Refseq protein id NP_001334150, NP_598633, XP_006539392, NP_001343496

Uniprot protein id Q6ZQ88

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Lysine (K)-specific demethylase 1A — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Lysine (K)-specific demethylase 1A — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Lysine (K)-specific demethylase 1A — UniProt protein ID (P352): Q6ZQ88. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Lysine (K)-specific demethylase 1A — part of (P361): Histone lysine-specific demethylase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Lysine (K)-specific demethylase 1A — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Lysine (K)-specific demethylase 1A — part of (P361): Homeobox-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Lysine (K)-specific demethylase 1A — part of (P361): FAD/NAD(P)-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Lysine (K)-specific demethylase 1A — part of (P361): SWIRM domain, protein family. wikidata.org.
[10] ↑ Lysine (K)-specific demethylase 1A — part of (P361): Amine oxidase domain, protein family. wikidata.org.
[11] ↑ Lysine (K)-specific demethylase 1A — has part(s) (P527): SWIRM domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Lysine (K)-specific demethylase 1A — has part(s) (P527): Amine oxidase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Lysine (K)-specific demethylase 1A — RefSeq protein ID (P637): NP_001334150. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Lysine (K)-specific demethylase 1A — RefSeq protein ID (P637): NP_598633. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Lysine (K)-specific demethylase 1A — RefSeq protein ID (P637): XP_006539392. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Lysine (K)-specific demethylase 1A — RefSeq protein ID (P637): NP_001343496. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Lysine (K)-specific demethylase 1A — molecular function (P680): DNA-binding transcription factor activity. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Lysine (K)-specific demethylase 1A — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Lysine (K)-specific demethylase 1A — molecular function (P680): protein binding. LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11.. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Lysine (K)-specific demethylase 1A — molecular function (P680): flavin adenine dinucleotide binding. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Lysine (K)-specific demethylase 1A — molecular function (P680): oxidoreductase activity. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Lysine (K)-specific demethylase 1A — molecular function (P680): p53 binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Lysine (K)-specific demethylase 1A — molecular function (P680): chromatin binding. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Lysine (K)-specific demethylase 1A — molecular function (P680): transcription factor binding. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Lysine (K)-specific demethylase 1A — molecular function (P680): enzyme binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Lysine (K)-specific demethylase 1A — molecular function (P680): nuclear receptor coactivator activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Lysine (K)-specific demethylase 1A is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Lysine (K)-specific demethylase 1A. Retrieved May 3, 2026, from https://4ort.xyz/entity/lysine-k-specific-demethylase-1a

MLA

“Lysine (K)-specific demethylase 1A.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/lysine-k-specific-demethylase-1a.

BibTeX

@misc{4ortxyz_lysine-k-specific-demethylase-1a_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Lysine (K)-specific demethylase 1A}}, year = {2026}, url = {https://4ort.xyz/entity/lysine-k-specific-demethylase-1a}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Lysine (K)-specific demethylase 1A — https://4ort.xyz/entity/lysine-k-specific-demethylase-1a (retrieved 2026-05-03)

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