lysine demethylase 1A

mammalian protein found in Homo sapiens

Protein protein Q21108161

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lysine demethylase 1A

Summary

lysine demethylase 1A is a protein^[1].

Key Facts

lysine demethylase 1A's instance of is recorded as protein^[2].
lysine demethylase 1A's physically interacts with is recorded as tranylcypromine^[3].
lysine demethylase 1A's physically interacts with is recorded as bomedemstat^[4].
lysine demethylase 1A's UniProt protein ID is recorded as O60341^[5].
lysine demethylase 1A's part of is recorded as Histone lysine-specific demethylase^[6].
lysine demethylase 1A's part of is recorded as Winged helix-like DNA-binding domain superfamily^[7].
lysine demethylase 1A's part of is recorded as Homeobox-like domain superfamily^[8].
lysine demethylase 1A's part of is recorded as FAD/NAD(P)-binding domain superfamily^[9].
lysine demethylase 1A's part of is recorded as SWIRM domain, protein family^[10].
lysine demethylase 1A's part of is recorded as Amine oxidase domain, protein family^[11].
lysine demethylase 1A's MeSH descriptor ID is recorded as C495195^[12].
lysine demethylase 1A's has part is recorded as Amine oxidase domain^[13].
lysine demethylase 1A's has part is recorded as SWIRM domain^[14].
lysine demethylase 1A's RefSeq protein ID is recorded as NP_001009999^[15].
lysine demethylase 1A's RefSeq protein ID is recorded as NP_055828^[16].
lysine demethylase 1A's RefSeq protein ID is recorded as XP_005245843^[17].
lysine demethylase 1A's RefSeq protein ID is recorded as XP_006710536^[18].
lysine demethylase 1A's RefSeq protein ID is recorded as XP_006710537^[19].
lysine demethylase 1A's RefSeq protein ID is recorded as XP_016856205^[20].
lysine demethylase 1A's RefSeq protein ID is recorded as XP_016856206^[21].
lysine demethylase 1A's RefSeq protein ID is recorded as NP_001350583^[22].
lysine demethylase 1A's PDB structure ID is recorded as 2COM^[23].
lysine demethylase 1A's PDB structure ID is recorded as 2DW4^[24].
lysine demethylase 1A's PDB structure ID is recorded as 2EJR^[25].
lysine demethylase 1A's PDB structure ID is recorded as 2H94^[26].

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Quick Facts

Instance of protein

Part of Histone lysine-specific demethylase, Winged helix-like DNA-binding domain superfamily, Homeobox-like domain superfamily, FAD/NAD(P)-binding domain superfamily, SWIRM domain, protein family, Amine oxidase domain, protein family

Properties

Biological process regulation of transcription, DNA-templated, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, regulation of double-strand break repair via homologous recombination, cellular response to UV, histone H3-K4 demethylation, regulation of transcription by RNA polymerase II, negative regulation of DNA binding, protein demethylation, positive regulation of DNA-binding transcription factor activity, blood coagulation, negative regulation of protein binding, negative regulation of DNA-binding transcription factor activity, transcription, DNA-templated, multicellular organism development, negative regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of histone ubiquitination, cellular response to gamma radiation, negative regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, alternative mRNA splicing, via spliceosome, cerebral cortex development, positive regulation of cell size, response to organic cyclic compound, guanine metabolic process, cellular response to cAMP, positive regulation of chromatin binding, histone deacetylation, positive regulation of neuron projection development, neuron maturation, response to fungicide, negative regulation of transcription by RNA polymerase II, histone H3-K9 demethylation, muscle cell development, chromatin organization, negative regulation of transcription by RNA polymerase II, positive regulation of neuroblast proliferation, positive regulation of transcription by RNA polymerase II, negative regulation of histone H3-K4 methylation, negative regulation of histone H3-K9 methylation, positive regulation of cold-induced thermogenesis, positive regulation of neural precursor cell proliferation, positive regulation of stem cell proliferation

Cell component DNA repair complex, nucleoplasm, nucleus, transcription regulator complex, protein-containing complex, nucleus

Encoded by KDM1A

Found in taxon Homo sapiens

Has part(s) Amine oxidase domain, SWIRM domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, telomeric repeat-containing RNA binding, demethylase activity, telomeric DNA binding, flavin adenine dinucleotide binding, p53 binding, protein binding, androgen receptor binding, nuclear receptor coactivator activity, histone H3-methyl-lysine-4 demethylase activity, oxidoreductase activity, chromatin binding, histone deacetylase activity, histone demethylase activity, enzyme binding, MRF binding, transcription factor binding, histone H3-methyl-lysine-9 demethylase activity, chromatin binding, transcription factor binding, oxidoreductase activity, flavin adenine dinucleotide binding, histone demethylase activity

Physically interacts with tranylcypromine, bomedemstat

External References (6)

Ensembl protein id ENSP00000349049, ENSP00000383042, ENSP00000473294, ENSP00000473297

Mesh descriptor id C495195

Pdb structure id 2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48, 2Z3Y, 2Z5U, 3ABT, 3ZMS, 3ZMT, 3ZMU, 3ZMV, 3ZMZ, 3ZN0, 3ZN1, 4BAY, 4CZZ, 4KUM, 4UV8, 4UV9, 4UVA, 4UVB, 4UVC, 4UXN, 5AFW, 5L3D, 5L3B, 5IT3, 5L3C, 4XBF

Refseq protein id NP_001009999, NP_055828, XP_005245843, XP_006710536, XP_006710537, XP_016856205, XP_016856206, NP_001350583

Umls cui C1531135

Uniprot protein id O60341

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ lysine demethylase 1A — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ lysine demethylase 1A — physically interacts with (P129): tranylcypromine. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ lysine demethylase 1A — physically interacts with (P129): bomedemstat. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[5] ↑ lysine demethylase 1A — UniProt protein ID (P352): O60341. Q905695. Retrieved 2019-11-13. wikidata.org.
[6] ↑ lysine demethylase 1A — part of (P361): Histone lysine-specific demethylase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ lysine demethylase 1A — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ lysine demethylase 1A — part of (P361): Homeobox-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ lysine demethylase 1A — part of (P361): FAD/NAD(P)-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ lysine demethylase 1A — part of (P361): SWIRM domain, protein family. wikidata.org.
[11] ↑ lysine demethylase 1A — part of (P361): Amine oxidase domain, protein family. wikidata.org.
[12] ↑ lysine demethylase 1A — MeSH descriptor ID (P486): C495195. wikidata.org.
[13] ↑ lysine demethylase 1A — has part(s) (P527): Amine oxidase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ lysine demethylase 1A — has part(s) (P527): SWIRM domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ lysine demethylase 1A — RefSeq protein ID (P637): NP_001009999. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ lysine demethylase 1A — RefSeq protein ID (P637): NP_055828. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ lysine demethylase 1A — RefSeq protein ID (P637): XP_005245843. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ lysine demethylase 1A — RefSeq protein ID (P637): XP_006710536. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ lysine demethylase 1A — RefSeq protein ID (P637): XP_006710537. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ lysine demethylase 1A — RefSeq protein ID (P637): XP_016856205. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ lysine demethylase 1A — RefSeq protein ID (P637): XP_016856206. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ lysine demethylase 1A — RefSeq protein ID (P637): NP_001350583. Q20641742. Retrieved 2020-05-30. wikidata.org.
[23] ↑ lysine demethylase 1A — PDB structure ID (P638): 2COM. Q905695. Retrieved 2016-08-09. wikidata.org.
[24] ↑ lysine demethylase 1A — PDB structure ID (P638): 2DW4. Q905695. Retrieved 2016-08-09. wikidata.org.
[25] ↑ lysine demethylase 1A — PDB structure ID (P638): 2EJR. Q905695. Retrieved 2016-08-09. wikidata.org.
[26] ↑ lysine demethylase 1A — PDB structure ID (P638): 2H94. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ lysine demethylase 1A is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). lysine demethylase 1A. Retrieved May 3, 2026, from https://4ort.xyz/entity/lysine-demethylase-1a-q21108161

MLA

“lysine demethylase 1A.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/lysine-demethylase-1a-q21108161.

BibTeX

@misc{4ortxyz_lysine-demethylase-1a-q21108161_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{lysine demethylase 1A}}, year = {2026}, url = {https://4ort.xyz/entity/lysine-demethylase-1a-q21108161}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): lysine demethylase 1A — https://4ort.xyz/entity/lysine-demethylase-1a-q21108161 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/lysine-demethylase-1a-q21108161 · Last refreshed: May 3, 2026