Lipinski's rule of five
rule of thumb that a compound is likely orally active if it violates at most one of: ≤5 hydrogen bond donors; ≤10 hydrogen bond acceptors; molecular mass of ≤500 Da; octanol-water partition coefficient of ≤5
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Lipinski's rule of five
Summary
Lipinski's rule of five is a rule of thumb[1]. It draws 241 Wikipedia views per month (rule_of_thumb category, ranking #3 of 22).[2]
Key Facts
- Lipinski's rule of five's instance of is recorded as rule of thumb[3].
- Christopher A. Lipinski is named after Lipinski's rule of five[4].
- Lipinski's rule of five's start time is recorded as +1997-00-00T00:00:00Z[5].
- Lipinski's rule of five's Freebase ID is recorded as /m/03f8mb[6].
- Lipinski's rule of five's Microsoft Academic ID is recorded as 41847442[7].
- Lipinski's rule of five's OpenAlex ID is recorded as C41847442[8].
- Lipinski's rule of five's ScienceDirect topic ID is recorded as pharmacology-toxicology-and-pharmaceutical-science/lipinskis-rule-of-five[9].
- Lipinski's rule of five's ScienceDirect topic ID is recorded as nursing-and-health-professions/lipinskis-rule-of-five[10].
Why It Matters
Lipinski's rule of five draws 241 Wikipedia views per month (rule_of_thumb category, ranking #3 of 22).[2] It has Wikipedia articles in 15 language editions, a strong signal of global cultural recognition.[11] It is known by 6 alternative names across languages and contexts.[12]