leukotriene C4 synthase

mammalian protein found in Homo sapiens
Protein protein Q6534538
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Summary

leukotriene C4 synthase is a protein[1]. It is known by 6 alternative names across languages and contexts.[2]

Key Facts

  • Part of: 5-lipoxygenase-activating protein[3], Membrane associated eicosanoid/glutathione metabolism-like domain superfamily[4], FLAP/GST2/LTC4S, conserved site, protein family[5]
  • Has part(s): FLAP/GST2/LTC4S, conserved site[6]
  • Molecular function: leukotriene-C4 synthase activity[7], glutathione peroxidase activity[8], protein binding[9], lyase activity[10], enzyme activator activity[11], lipid binding[12], identical protein binding[13], glutathione transferase activity[14]
  • Cell component: integral component of membrane[15], membrane[16], nuclear envelope[17], endoplasmic reticulum[18], nuclear outer membrane[19], nucleus[20], intracellular membrane-bounded organelle[21], endoplasmic reticulum membrane[22]
  • Biological process: positive regulation of catalytic activity[23], leukotriene biosynthetic process[24], cellular oxidant detoxification[25], leukotriene metabolic process[26], long-chain fatty acid biosynthetic process[27], lipoxygenase pathway[28], lipoxin biosynthetic process[29]
  • Encoded by: LTC4S[30]
  • Found in taxon: Homo sapiens[31]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . wikidata.org.
  4. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [7] ↑ . Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . Purification of human leukotriene C4 synthase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . UniProt. Retrieved . wikidata.org.
  29. [31] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). leukotriene C4 synthase. Retrieved May 3, 2026, from https://4ort.xyz/entity/leukotriene-c4-synthase-q6534538
MLA “leukotriene C4 synthase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/leukotriene-c4-synthase-q6534538.
BibTeX @misc{4ortxyz_leukotriene-c4-synthase-q6534538_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{leukotriene C4 synthase}}, year = {2026}, url = {https://4ort.xyz/entity/leukotriene-c4-synthase-q6534538}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): leukotriene C4 synthase — https://4ort.xyz/entity/leukotriene-c4-synthase-q6534538 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/leukotriene-c4-synthase-q6534538 · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Uniprot protein id → Juan Carlos Onetti
    Ec enzyme number → 4.4.1.20
    Refseq protein id → NP_665874
    Imported from → —
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 4.4.1.20, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"
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