leptin

mammalian protein found in Homo sapiens
Protein protein Q223739
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leptin

Summary

leptin is a protein[1]. leptin ranks in the top 1% of protein entities by monthly Wikipedia readership (258 views/month).[2]

Key Facts

  • leptin's instance of is recorded as protein[3].
  • leptin is part of leptin[4].
  • leptin is part of four-helical cytokine-like, core[5].
  • leptin's Commons category is recorded as Leptin (obesity protein)[6].
  • leptin's HomoloGene ID is recorded as 193[7].
  • leptin's molecular function is recorded as hormone activity[8].
  • leptin's molecular function is recorded as peptide hormone receptor binding[9].
  • leptin's molecular function is recorded as signaling receptor binding[10].
  • leptin's cell component is recorded as cytoplasm[11].
  • leptin's cell component is recorded as extracellular region[12].
  • leptin's cell component is recorded as extracellular space[13].
  • leptin's biological process is recorded as regulation of protein phosphorylation[14].
  • leptin's biological process is recorded as response to dietary excess[15].
  • leptin's biological process is recorded as cellular response to retinoic acid[16].
  • leptin's biological process is recorded as positive regulation of developmental growth[17].
  • leptin's biological process is recorded as negative regulation of glucagon secretion[18].
  • leptin's biological process is recorded as placenta development[19].
  • leptin's biological process is recorded as cardiac muscle hypertrophy[20].
  • leptin's biological process is recorded as regulation of angiogenesis[21].
  • leptin's biological process is recorded as prostaglandin secretion[22].
  • leptin's biological process is recorded as regulation of intestinal cholesterol absorption[23].
  • leptin's biological process is recorded as T cell differentiation[24].
  • leptin's biological process is recorded as positive regulation of reactive oxygen species metabolic process[25].
  • leptin's biological process is recorded as central nervous system neuron development[26].
  • leptin's biological process is recorded as circadian rhythm[27].

Why It Matters

leptin ranks in the top 1% of protein entities by monthly Wikipedia readership (258 views/month).[2] leptin has Wikipedia articles in 27 language editions, a strong signal of global cultural recognition.[28] leptin is known by 11 alternative names across languages and contexts.[29]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Q905695. Retrieved . wikidata.org.
  2. [4] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] . wikidata.org.
  5. [7] . wikidata.org.
  6. [8] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] . A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] . Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] . Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] . Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [28] . Wikidata sitelinks. wikidata.org.
  3. [29] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). leptin. Retrieved May 3, 2026, from https://4ort.xyz/entity/leptin
MLA “leptin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/leptin.
BibTeX @misc{4ortxyz_leptin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{leptin}}, year = {2026}, url = {https://4ort.xyz/entity/leptin}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): leptin — https://4ort.xyz/entity/leptin (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/leptin · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 2d ago · Twofivesixbot bot · 2026-05-18 view diff on Wikidata ↗
    Instance of protein
    Found in taxon Homo sapiens
    Part of leptin, four-helical cytokine-like, core
    Cell component cytoplasm, extracellular region, extracellular space
    + 7 other properties edited (see Wikidata diff for full list)
    "/* wbsetclaim-update-qualifiers:1||1|4 */ [[Property:P2347]]: 11607, mv to monolingual text names on YSO statements"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.