LEM domain containing 2

mammalian protein found in Mus musculus
Protein Q21495909

Facts

8 properties
Instance of
protein
Part of
LEM/LEM-like domain superfamily, LEM domain-containing protein 2, membrane protein, LEM domain, protein family, Man1/Src1, C-terminal domain, protein family[2][3][4][5][6]
Biological process
skeletal muscle cell differentiation, neurogenesis, negative regulation of protein kinase B signaling, heart formation, negative regulation of MAPK cascade, nuclear envelope organization, negative regulation of BMP signaling pathway, meiotic attachment of telomere to nuclear envelope, regulation of intracellular signal transduction, protein localization to chromatin[20][21][22][23]
Cell component
integral component of membrane, nuclear inner membrane, nuclear membrane, membrane, nucleus, integral component of nuclear inner membrane, chromatin, nuclear envelope, endoplasmic reticulum, membrane[10][11][12][13][14][15][16][17][18][19]
Encoded by
Lemd2
Found in taxon
house mouse
Has part(s)
Man1/Src1, C-terminal, LEM domain[7][8]
Molecular function
chromatin DNA binding[9]
🏷️ Also known as
en Lemd2 en LEM domain containing 2 en LEM domain-containing protein 2 en NET25 en nuclear envelope constituent en nuclear envelope transmembrane protein 25
🔖 Identifiers · 3
RefSeq protein ID
NP_666187
UniProt protein ID
Q6DVA0

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Summary

LEM domain containing 2 is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). LEM domain containing 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/lem-domain-containing-2
MLA “LEM domain containing 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/lem-domain-containing-2.
BibTeX @misc{4ortxyz_lem-domain-containing-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{LEM domain containing 2}}, year = {2026}, url = {https://4ort.xyz/entity/lem-domain-containing-2}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): LEM domain containing 2 — https://4ort.xyz/entity/lem-domain-containing-2 (retrieved 2026-05-03)

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