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laronidase

pharmaceutical drug
Class type of: alpha-glucosidase, IDUA Q20801774

Facts

14 properties
Instance of
protein
Subclass of
alpha-glucosidase, IDUA
Part of
Immunoglobulin-like fold, glycoside hydrolase superfamily, Glycoside hydrolase, family 39[4][5][6]
Has use
medication[7]
Active ingredient in
Aldurazyme[30]
Biological process
chondroitin sulfate catabolic process, disaccharide metabolic process, metabolism, glycosaminoglycan catabolic process, dermatan sulfate catabolic process, carbohydrate metabolic process, heparin catabolic process[18][19][20][21][22][23][24]
Cell component
lysosome, lysosomal lumen, coated vesicle, extracellular exosome, extracellular exosome[14][15][16][17]
EC enzyme number
3.2.1.76[8]
Encoded by
IDUA[25]
Found in taxon
Homo sapiens[26]
Has characteristic
biopharmaceutical[27]
Legal status (medicine)
boxed warning[29]
Medical condition treated
mucopolysaccharidosis I[28]
Molecular function
L-iduronidase activity, hydrolase activity, hydrolyzing O-glycosyl compounds, signaling receptor binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, L-iduronidase activity[9][10][11][12][13]
🏷️ Also known as
en mucopolysaccharidosis type I en α-L-iduronidase en alpha-L-iduronidase en alpha-L-iduronidase precursor en human alpha-L-iduronidase en IDUA en laronidase ar ايدورونيداز de Iduronidase es Laronidasa fa ایدرونیداز fr iduronidase ja α-L-イズロニダーゼ pl alfa-L-iduronidaza pl iduronidaza zh 艾杜糖苷酸酶
🔖 Identifiers · 18
ATC code
A16AB05
CAS Registry Number
210589-09-6
ChEMBL ID
CHEMBL1201595
DrugBank ID
DB00090
Ensembl protein ID
ENSP00000247933, ENSP00000422952, ENSP00000424847, ENSP00000425081
Exact match
purl.uniprot.org
Freebase ID
/m/0fmwxw
MeSH descriptor ID
D007068
MeSH tree code
D08.811.277.450.560
Microsoft Academic ID (discontinued)
2780623936, 2910090482
NDF-RT ID
N0000148807
PDB structure ID
3W81, 3W82, 4KGJ, 4KGL, 4KH2, 4MJ2, 4MJ4, 4OBR, 4OBS
Show all 18 identifiers +6
RefSeq protein ID
NP_000194, XP_011511763, XP_016863652, NP_001350505
RxNorm CUI
392509
UMLS CUI
C0020818
UNII
WP58SVM6R4
UniProt protein ID
P35475
WikiProjectMed ID
Laronidase

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Cell component 3
lysosome, extracellular exosome, extracellular exosome
Biological process 2
metabolism, carbohydrate metabolic process
Found in taxon 1
Homo sapiens
Has characteristic 1
biopharmaceutical
Has use 1
medication
Instance of 1
protein
Legal status (medicine) 1
boxed warning
Medical condition treated 1
mucopolysaccharidosis I
Part of 1
glycoside hydrolase superfamily
Subclass of 1
alpha-glucosidase
← Drug or therapy used for treatment 1
mucopolysaccharidosis I
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Summary

laronidase is a protein[1]. laronidase is a type of alpha-glucosidase[2] and IDUA[3].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . NDF-RT. Retrieved . wikidata.org.
  2. [3] ↑ . wikidata.org.
  3. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] ↑ . DrugBank. wikidata.org.
  7. [8] ↑ . UniProt. Retrieved . wikidata.org.
  8. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . Immunopurification and characterization of human alpha-L-iduronidase with the use of monoclonal antibodies. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . Insights into mucopolysaccharidosis I from the structure and action of α-L-iduronidase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking α-l-iduronidase.. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] ↑ . UniProt. Retrieved . wikidata.org.
  25. [26] ↑ . UniProt. Retrieved . wikidata.org.
  26. [27] ↑ . DrugBank. wikidata.org.
  27. [28] ↑ . NDF-RT. Retrieved . wikidata.org.
  28. [29] ↑ . nctr-crs.fda.gov. nctr-crs.fda.gov. Provenance: wikidata.org.
  29. [30] ↑ . ema.europa.eu. Retrieved . ema.europa.eu. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). laronidase. Retrieved November 11, 2026, from https://4ort.xyz/entity/laronidase
MLA “laronidase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 11 Nov. 2026, https://4ort.xyz/entity/laronidase.
BibTeX @misc{4ortxyz_laronidase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{laronidase}}, year = {2026}, url = {https://4ort.xyz/entity/laronidase}, note = {Accessed: 2026-11-11}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 16w ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Active ingredient in → Aldurazyme
    Subclass of → alpha-glucosidase, IDUA
    Encoded by → IDUA
    Biological process → chondroitin sulfate catabolic process, disaccharide metabolic process, metabolism +1
    + 10 other properties edited (see Wikidata diff for full list)
    "Created claim: EC enzyme number: 3.2.1.76, batch #261457"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.