Kruppel-like factor 4 (gut)

mammalian protein found in Mus musculus

Protein protein Q21983400

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Kruppel-like factor 4 (gut)

Summary

Kruppel-like factor 4 (gut) is a protein^[1].

Key Facts

Kruppel-like factor 4 (gut)'s instance of is recorded as protein^[2].
Kruppel-like factor 4 (gut)'s subclass of is recorded as protein^[3].
Kruppel-like factor 4 (gut)'s UniProt protein ID is recorded as Dora Ratjen^[4].
Kruppel-like factor 4 (gut)'s part of is recorded as Zinc finger C2H2 superfamily^[5].
Kruppel-like factor 4 (gut)'s part of is recorded as Zinc finger C2H2-type, protein family^[6].
Kruppel-like factor 4 (gut)'s has part is recorded as Zinc finger C2H2-type^[7].
Kruppel-like factor 4 (gut)'s RefSeq protein ID is recorded as NP_034767^[8].
Kruppel-like factor 4 (gut)'s RefSeq protein ID is recorded as XP_036019641^[9].
Kruppel-like factor 4 (gut)'s PDB structure ID is recorded as 2WBS^[10].
Kruppel-like factor 4 (gut)'s PDB structure ID is recorded as 2WBU^[11].
Kruppel-like factor 4 (gut)'s PDB structure ID is recorded as 4M9E^[12].
Kruppel-like factor 4 (gut)'s molecular function is recorded as DNA binding^[13].
Kruppel-like factor 4 (gut)'s molecular function is recorded as beta-catenin binding^[14].
Kruppel-like factor 4 (gut)'s molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[15].
Kruppel-like factor 4 (gut)'s molecular function is recorded as transcription factor binding^[16].
Kruppel-like factor 4 (gut)'s molecular function is recorded as cis-regulatory region sequence-specific DNA binding^[17].
Kruppel-like factor 4 (gut)'s molecular function is recorded as metal ion binding^[18].
Kruppel-like factor 4 (gut)'s molecular function is recorded as RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity^[19].
Kruppel-like factor 4 (gut)'s molecular function is recorded as nucleic acid binding^[20].
Kruppel-like factor 4 (gut)'s molecular function is recorded as promoter-specific chromatin binding^[21].
Kruppel-like factor 4 (gut)'s molecular function is recorded as protein binding^[22].
Kruppel-like factor 4 (gut)'s molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[23].
Kruppel-like factor 4 (gut)'s molecular function is recorded as transcription coregulator binding^[24].
Kruppel-like factor 4 (gut)'s molecular function is recorded as double-stranded DNA binding^[25].
Kruppel-like factor 4 (gut)'s molecular function is recorded as DNA-binding transcription factor activity^[26].

⭐ Popularity Graph

1/100 established

Quick Facts

Instance of protein

Subclass of protein

Part of Zinc finger C2H2 superfamily, Zinc finger C2H2-type, protein family

Properties

Biological process negative regulation of chemokine (C-X-C motif) ligand 2 production, epidermal cell differentiation, cellular response to retinoic acid, cell differentiation, positive regulation of protein metabolic process, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, regulation of transcription, DNA-templated, regulation of axon regeneration, cellular response to peptide, positive regulation of hemoglobin biosynthetic process, response to retinoic acid, cellular response to laminar fluid shear stress, regulation of transcription by RNA polymerase II, epidermis morphogenesis, positive regulation of nitric oxide biosynthetic process, cellular response to growth factor stimulus, cellular response to organic cyclic compound, post-embryonic hemopoiesis, negative regulation of transcription by RNA polymerase II, response to organic substance, negative regulation of DNA-binding transcription factor activity, transcription, DNA-templated, negative regulation of response to cytokine stimulus, stem cell population maintenance, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of cell migration, regulation of cell population proliferation, post-embryonic camera-type eye development, positive regulation of telomerase activity, canonical Wnt signaling pathway, regulation of cell differentiation, negative regulation of heterotypic cell-cell adhesion, negative regulation of transcription, DNA-templated, negative regulation of NF-kappaB transcription factor activity, cellular response to cycloheximide, fat cell differentiation, negative regulation of cell population proliferation, cellular response to hydrogen peroxide, positive regulation of gene expression, regulation of phosphatidylinositol 3-kinase activity, negative regulation of gene expression, negative regulation of leukocyte adhesion to arterial endothelial cell, transcription by RNA polymerase II, positive regulation of core promoter binding, positive regulation of transcription by RNA polymerase II, cellular response to leukemia inhibitory factor, negative regulation of angiogenesis, pri-miRNA transcription by RNA polymerase II, negative regulation of G1/S transition of mitotic cell cycle, positive regulation of transcription, DNA-templated, positive regulation of sprouting angiogenesis, negative regulation of phosphatidylinositol 3-kinase signaling, negative regulation of muscle hyperplasia, negative regulation of smooth muscle cell proliferation, negative regulation of protein kinase B signaling, negative regulation of ERK1 and ERK2 cascade, transcription, DNA-templated, regulation of transcription by RNA polymerase II

Cell component cytoplasm, nucleoplasm, chromatin, nucleus, transcription regulator complex, nucleus, nucleoplasm

Encoded by Klf4

Found in taxon house mouse

Has part(s) Zinc finger C2H2-type

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, beta-catenin binding, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor binding, cis-regulatory region sequence-specific DNA binding, metal ion binding, RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity, nucleic acid binding, promoter-specific chromatin binding, protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription coregulator binding, double-stranded DNA binding, DNA-binding transcription factor activity, phosphatidylinositol 3-kinase regulator activity, histone deacetylase binding, sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (4)

Ensembl protein id ENSMUSP00000103245, ENSMUSP00000116514, ENSMUSP00000123687

Pdb structure id 2WBS, 2WBU, 4M9E

Refseq protein id NP_034767, XP_036019641

Uniprot protein id Dora Ratjen

🏷️ Also known as

en epithelial zinc finger protein EZF en gut-enriched krueppel-like factor en Klf4 en Krueppel-like factor 4 en Kruppel-like factor 4 (gut) en Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF) en kruppel-like factor 4 isoform Klf4-108 en kruppel-like factor 4 isoform Klf4-1355 en kruppel-like factor 4 isoform Klf4-1482 en kruppel-like factor 4 isoform Klf4-178 en kruppel-like factor 4 isoform Klf4-343 en kruppel-like factor 4 isoform Klf4-375 en kruppel-like factor 4 isoform Klf4-51 en kruppel-like factor 4 isoform Klf4-550 en kruppel-like factor 4 isoform Klf4-725 nl Kruppel-like factor 4

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Kruppel-like factor 4 (gut) — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Kruppel-like factor 4 (gut) — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Kruppel-like factor 4 (gut) — UniProt protein ID (P352): Dora Ratjen. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Kruppel-like factor 4 (gut) — part of (P361): Zinc finger C2H2 superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Kruppel-like factor 4 (gut) — part of (P361): Zinc finger C2H2-type, protein family. wikidata.org.
[7] ↑ Kruppel-like factor 4 (gut) — has part(s) (P527): Zinc finger C2H2-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Kruppel-like factor 4 (gut) — RefSeq protein ID (P637): NP_034767. Q20641742. Retrieved 2022-03-20. wikidata.org.
[9] ↑ Kruppel-like factor 4 (gut) — RefSeq protein ID (P637): XP_036019641. Q20641742. Retrieved 2022-03-20. wikidata.org.
[10] ↑ Kruppel-like factor 4 (gut) — PDB structure ID (P638): 2WBS. Q905695. Retrieved 2016-08-09. wikidata.org.
[11] ↑ Kruppel-like factor 4 (gut) — PDB structure ID (P638): 2WBU. Q905695. Retrieved 2016-08-09. wikidata.org.
[12] ↑ Kruppel-like factor 4 (gut) — PDB structure ID (P638): 4M9E. Q905695. Retrieved 2016-08-09. wikidata.org.
[13] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): DNA binding. Mammalian SP/KLF transcription factors: bring in the family. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): beta-catenin binding. Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): transcription factor binding. Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity. Transcriptional regulation of adipogenesis by KLF4. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): nucleic acid binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): promoter-specific chromatin binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): protein binding. Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): transcription coregulator binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): double-stranded DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Kruppel-like factor 4 (gut) — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Kruppel-like factor 4 (gut) is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_kruppel-like-factor-4-gut-_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Kruppel-like factor 4 (gut)}}, year = {2026}, url = {https://4ort.xyz/entity/kruppel-like-factor-4-gut-}, note = {Accessed: 2026-05-03}}

LLM prompt

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Canonical URL: https://4ort.xyz/entity/kruppel-like-factor-4-gut- · Last refreshed: May 3, 2026