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Kininogen 1

mammalian protein found in Homo sapiens
Protein protein Q21108132

Facts

9 properties
Instance of
protein
Part of
HMW kininogen, cystatins, Kininogen-type cystatin domain, protein family, Proteinase inhibitor I25, cystatin, conserved site, protein family[2][3][4][5]
Biological process
hemostasis, blood coagulation, intrinsic pathway, negative regulation of proteolysis, negative regulation of cell adhesion, negative regulation of peptidase activity, negative regulation of blood coagulation, positive regulation of cytosolic calcium ion concentration, platelet degranulation, vasodilation, positive regulation of apoptotic process, inflammatory response, blood coagulation, negative regulation of endopeptidase activity, post-translational protein modification, G protein-coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, negative regulation of endopeptidase activity, negative regulation of blood coagulation
Cell component
blood microparticle, plasma membrane, extracellular exosome, platelet alpha granule lumen, extracellular space, endoplasmic reticulum lumen, extracellular matrix, extracellular region, extracellular region, collagen-containing extracellular matrix, extracellular exosome, blood microparticle
Encoded by
KNG1
Found in taxon
Homo sapiens
Has part(s)
Cystatin domain, Proteinase inhibitor I25, cystatin, conserved site, Kininogen-type cystatin domain[6][7][8]
Imported from
wholeness_audit_2026-05-02
Molecular function
peptidase inhibitor activity, heparin binding, zinc ion binding, protein binding, signaling receptor binding, cysteine-type endopeptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity[9][10][11][12][13][14]
🏷️ Also known as
en alpha-2-thiol proteinase inhibitor en bradykinin en fitzgerald factor en high molecular weight kininogen en HMWK en kininogen-1 en Kininogen 1 en KNG1 en williams-Fitzgerald-Flaujeac factor
🔖 Identifiers · 5
Ensembl protein ID
ENSP00000287611, ENSP00000396025, ENSP00000493985
Exact match
identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov
PDB structure ID
1NY2, 2WOK, 4ASQ, 4ASR, 4ECB, 4ECC, 5I25
RefSeq protein ID
NP_000884, NP_001095886, NP_001159923
UniProt protein ID
P01042

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Summary

Kininogen 1 is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . wikidata.org.
  3. [4] ↑ . wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . Fine mapping of the sequences in domain 5 of high molecular weight kininogen (HK) interacting with heparin and zinc. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . Fine mapping of the sequences in domain 5 of high molecular weight kininogen (HK) interacting with heparin and zinc. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Kininogen 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/kininogen-1
MLA “Kininogen 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/kininogen-1.
BibTeX @misc{4ortxyz_kininogen-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Kininogen 1}}, year = {2026}, url = {https://4ort.xyz/entity/kininogen-1}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Kininogen 1 — https://4ort.xyz/entity/kininogen-1 (retrieved 2026-05-03)

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