Janus kinase 2

mammalian protein found in Mus musculus

Protein protein Q14914518

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Janus kinase 2

Summary

Janus kinase 2 is a protein^[1].

Key Facts

Janus kinase 2's instance of is recorded as protein^[2].
Janus kinase 2's UniProt protein ID is recorded as Tomas Behrend^[3].
Janus kinase 2's part of is recorded as Protein kinase-like domain superfamily^[4].
Janus kinase 2's part of is recorded as tyrosine-protein kinase, non-receptor Jak2^[5].
Janus kinase 2's part of is recorded as SH2 domain superfamily^[6].
Janus kinase 2's part of is recorded as FERM superfamily, second domain^[7].
Janus kinase 2's part of is recorded as membrane protein^[8].
Janus kinase 2's part of is recorded as Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[9].
Janus kinase 2's part of is recorded as SH2 domain, protein family^[10].
Janus kinase 2's part of is recorded as Band 4.1 domain, protein family^[11].
Janus kinase 2's part of is recorded as Janus kinase 2, pseudokinase domain, protein family^[12].
Janus kinase 2's part of is recorded as Janus kinase 2, catalytic domain, protein family^[13].
Janus kinase 2's part of is recorded as JAK2, FERM domain C-lobe, protein family^[14].
Janus kinase 2's part of is recorded as Tyrosine-protein kinase JAK2, SH2 domain, protein family^[15].
Janus kinase 2's part of is recorded as FERM domain, protein family^[16].
Janus kinase 2's part of is recorded as Protein kinase domain, protein family^[17].
Janus kinase 2's part of is recorded as Protein kinase, ATP binding site, protein family^[18].
Janus kinase 2's part of is recorded as Tyrosine-protein kinase, catalytic domain, protein family^[19].
Janus kinase 2's part of is recorded as Tyrosine-protein kinase, active site, protein family^[20].
Janus kinase 2's has part is recorded as SH2 domain^[21].
Janus kinase 2's has part is recorded as tyrosine-protein kinase, catalytic domain^[22].
Janus kinase 2's has part is recorded as tyrosine-protein kinase, active site^[23].
Janus kinase 2's has part is recorded as FERM domain^[24].
Janus kinase 2's has part is recorded as serine-threonine/tyrosine-protein kinase, catalytic domain^[25].
Janus kinase 2's has part is recorded as protein kinase, ATP binding site^[26].

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Quick Facts

Instance of protein

Part of Protein kinase-like domain superfamily, tyrosine-protein kinase, non-receptor Jak2, SH2 domain superfamily, FERM superfamily, second domain, membrane protein, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, SH2 domain, protein family, Band 4.1 domain, protein family, Janus kinase 2, pseudokinase domain, protein family, Janus kinase 2, catalytic domain, protein family, JAK2, FERM domain C-lobe, protein family, Tyrosine-protein kinase JAK2, SH2 domain, protein family, FERM domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process myeloid cell differentiation, adaptive immune response, negative regulation of DNA binding, tumor necrosis factor-mediated signaling pathway, protein phosphorylation, regulation of cell adhesion, growth hormone receptor signaling pathway, activation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of cell population proliferation, mammary gland epithelium development, extrinsic apoptotic signaling pathway, cytokine-mediated signaling pathway, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, response to antibiotic, positive regulation of apoptotic signaling pathway, response to tumor necrosis factor, response to interleukin-12, positive regulation of tumor necrosis factor production, positive regulation of peptidyl-tyrosine phosphorylation, erythrocyte differentiation, cellular response to interleukin-3, innate immune response, positive regulation of cell-substrate adhesion, positive regulation of growth hormone receptor signaling pathway, cell differentiation, phosphorylation, immune system process, post-embryonic hemopoiesis, negative regulation of apoptotic process, programmed cell death induced by symbiont, cellular response to dexamethasone stimulus, response to lipopolysaccharide, regulation of inflammatory response, peptidyl-tyrosine autophosphorylation, enzyme linked receptor protein signaling pathway, intracellular signal transduction, response to granulocyte macrophage colony-stimulating factor, positive regulation of phosphatidylinositol 3-kinase signaling, peptidyl-tyrosine phosphorylation, cellular response to lipopolysaccharide, cell migration, signal transduction, positive regulation of transcription by RNA polymerase II, inflammatory response, positive regulation of tyrosine phosphorylation of STAT protein, activation of Janus kinase activity, interleukin-12-mediated signaling pathway, chromatin organization, regulation of receptor signaling pathway via JAK-STAT, response to oxidative stress, G protein-coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, receptor signaling pathway via JAK-STAT, tyrosine phosphorylation of STAT protein, positive regulation of cell population proliferation, intrinsic apoptotic signaling pathway in response to oxidative stress, hormone-mediated signaling pathway, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell-cell adhesion, positive regulation of cell migration, axon regeneration, mineralocorticoid receptor signaling pathway, positive regulation of insulin secretion, positive regulation of phosphoprotein phosphatase activity, positive regulation of interleukin-1 beta production, response to hydroperoxide, positive regulation of apoptotic process, positive regulation of DNA binding, negative regulation of neuron apoptotic process, positive regulation of nitric oxide biosynthetic process, positive regulation of cell differentiation, negative regulation of heart contraction, protein autophosphorylation, platelet-derived growth factor receptor signaling pathway, positive regulation of inflammatory response, positive regulation of cell activation, positive regulation of DNA-binding transcription factor activity, positive regulation of nitric-oxide synthase biosynthetic process, interferon-gamma-mediated signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, negative regulation of cell death, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, positive regulation of epithelial cell apoptotic process, positive regulation of vascular associated smooth muscle cell proliferation, tyrosine phosphorylation of STAT protein, cytokine-mediated signaling pathway, erythrocyte differentiation, innate immune response, regulation of nitric oxide biosynthetic process, modulation of chemical synaptic transmission, postsynapse to nucleus signaling pathway, positive regulation of cold-induced thermogenesis, microglial cell activation, receptor signaling pathway via JAK-STAT, positive regulation of MHC class II biosynthetic process, positive regulation of nitric-oxide synthase biosynthetic process

Cell component cytoplasm, membrane, extrinsic component of cytoplasmic side of plasma membrane, caveola, cytoskeleton, nucleus, membrane raft, endomembrane system, nucleoplasm, plasma membrane, focal adhesion, cytosol, nuclear matrix, postsynapse, glutamatergic synapse

Encoded by Jak2

Found in taxon house mouse

Has part(s) SH2 domain, tyrosine-protein kinase, catalytic domain, tyrosine-protein kinase, active site, FERM domain, serine-threonine/tyrosine-protein kinase, catalytic domain, protein kinase, ATP binding site, Band 4.1 domain, protein kinase domain, Janus kinase 2, catalytic domain, Janus kinase 2, pseudokinase domain, Tyrosine-protein kinase JAK2, SH2 domain, JAK2, FERM domain C-lobe

Imported from wholeness_audit_2026-05-02

Molecular function SH2 domain binding, kinase activity, signaling receptor binding, ATP binding, protein kinase activity, interleukin-12 receptor binding, metal ion binding, heme binding, histone kinase activity (H3-Y41 specific), transferase activity, histone binding, protein binding, protein tyrosine kinase activity, protein kinase binding, nucleotide binding, non-membrane spanning protein tyrosine kinase activity, identical protein binding, growth hormone receptor binding, protein C-terminus binding, type 1 angiotensin receptor binding, acetylcholine receptor binding, phosphatidylinositol 3-kinase binding, insulin receptor substrate binding, peptide hormone receptor binding, protein tyrosine kinase activity

External References (4)

Ensembl protein id ENSMUSP00000025705, ENSMUSP00000064394

Pdb structure id 2HDX, 4GL9

Refseq protein id NP_001041642, NP_032439, XP_006526776, XP_006526777, XP_006526778, XP_011245457, XP_017173557

Uniprot protein id Tomas Behrend

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Janus kinase 2 — instance of (P31): protein. Q905695. Retrieved 2018-09-12. wikidata.org.
[3] ↑ Janus kinase 2 — UniProt protein ID (P352): Tomas Behrend. Q905695. Retrieved 2018-09-12. wikidata.org.
[4] ↑ Janus kinase 2 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Janus kinase 2 — part of (P361): tyrosine-protein kinase, non-receptor Jak2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Janus kinase 2 — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Janus kinase 2 — part of (P361): FERM superfamily, second domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Janus kinase 2 — part of (P361): membrane protein. wikidata.org.
[9] ↑ Janus kinase 2 — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[10] ↑ Janus kinase 2 — part of (P361): SH2 domain, protein family. wikidata.org.
[11] ↑ Janus kinase 2 — part of (P361): Band 4.1 domain, protein family. wikidata.org.
[12] ↑ Janus kinase 2 — part of (P361): Janus kinase 2, pseudokinase domain, protein family. wikidata.org.
[13] ↑ Janus kinase 2 — part of (P361): Janus kinase 2, catalytic domain, protein family. wikidata.org.
[14] ↑ Janus kinase 2 — part of (P361): JAK2, FERM domain C-lobe, protein family. wikidata.org.
[15] ↑ Janus kinase 2 — part of (P361): Tyrosine-protein kinase JAK2, SH2 domain, protein family. wikidata.org.
[16] ↑ Janus kinase 2 — part of (P361): FERM domain, protein family. wikidata.org.
[17] ↑ Janus kinase 2 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[18] ↑ Janus kinase 2 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[19] ↑ Janus kinase 2 — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[20] ↑ Janus kinase 2 — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[21] ↑ Janus kinase 2 — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Janus kinase 2 — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Janus kinase 2 — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Janus kinase 2 — has part(s) (P527): FERM domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Janus kinase 2 — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Janus kinase 2 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Janus kinase 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Janus kinase 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/janus-kinase-2-q14914518

MLA “Janus kinase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/janus-kinase-2-q14914518.

BibTeX

@misc{4ortxyz_janus-kinase-2-q14914518_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Janus kinase 2}}, year = {2026}, url = {https://4ort.xyz/entity/janus-kinase-2-q14914518}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Janus kinase 2 — https://4ort.xyz/entity/janus-kinase-2-q14914518 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/janus-kinase-2-q14914518 · Last refreshed: May 3, 2026