Itchy E3 ubiquitin protein ligase

mammalian protein found in Homo sapiens

Protein protein Q21109507

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Itchy E3 ubiquitin protein ligase

Summary

Itchy E3 ubiquitin protein ligase is a protein^[1].

Key Facts

Itchy E3 ubiquitin protein ligase's instance of is recorded as protein^[2].
Itchy E3 ubiquitin protein ligase's UniProt protein ID is recorded as Q96J02^[3].
Itchy E3 ubiquitin protein ligase's part of is recorded as HECT, E3 ligase catalytic domain^[4].
Itchy E3 ubiquitin protein ligase's part of is recorded as WW domain superfamily^[5].
Itchy E3 ubiquitin protein ligase's part of is recorded as C2 domain superfamily^[6].
Itchy E3 ubiquitin protein ligase's part of is recorded as E3 ubiquitin-protein ligase, SMURF1 type^[7].
Itchy E3 ubiquitin protein ligase's part of is recorded as HECT domain, protein family^[8].
Itchy E3 ubiquitin protein ligase's part of is recorded as C2 domain, protein family^[9].
Itchy E3 ubiquitin protein ligase's part of is recorded as WW domain, protein family^[10].
Itchy E3 ubiquitin protein ligase's has part is recorded as C2 domain^[11].
Itchy E3 ubiquitin protein ligase's has part is recorded as WW domain^[12].
Itchy E3 ubiquitin protein ligase's has part is recorded as HECT domain^[13].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001244066^[14].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001244067^[15].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001311126^[16].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_001311127^[17].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as NP_113671^[18].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_005260627^[19].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_011527381^[20].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_016883578^[21].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_016883579^[22].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_016883580^[23].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_016883581^[24].
Itchy E3 ubiquitin protein ligase's RefSeq protein ID is recorded as XP_024307773^[25].
Itchy E3 ubiquitin protein ligase's PDB structure ID is recorded as 2DMV^[26].

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Quick Facts

Instance of protein

Part of HECT, E3 ligase catalytic domain, WW domain superfamily, C2 domain superfamily, E3 ubiquitin-protein ligase, SMURF1 type, HECT domain, protein family, C2 domain, protein family, WW domain, protein family

Properties

Biological process Notch signaling pathway, protein K29-linked ubiquitination, immune system process, protein K63-linked ubiquitination, negative regulation of apoptotic process, defense response to virus, regulation of cell growth, viral entry into host cell, negative regulation of type I interferon production, inflammatory response, viral process, nucleotide-binding oligomerization domain containing signaling pathway, apoptotic process, innate immune response, protein polyubiquitination, positive regulation of T cell anergy, ubiquitin-dependent protein catabolic process, negative regulation of NF-kappaB transcription factor activity, positive regulation of protein catabolic process, negative regulation of JNK cascade, negative regulation of alpha-beta T cell proliferation, negative regulation of defense response to virus, protein K48-linked ubiquitination, regulation of protein deubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of hematopoietic stem cell differentiation, protein ubiquitination, protein autoubiquitination, positive regulation of receptor catabolic process, protein polyubiquitination, ubiquitin-dependent protein catabolic process, protein ubiquitination, protein K29-linked ubiquitination, positive regulation of protein catabolic process, protein K63-linked ubiquitination, protein K48-linked ubiquitination

Cell component cytosol, extracellular exosome, plasma membrane, membrane, nucleoplasm, nucleus, cell cortex, cytoplasmic vesicle, cytoplasm, early endosome, endosome, endosome membrane, early endosome membrane, membrane, protein-containing complex, intracellular membrane-bounded organelle, extracellular exosome

Encoded by ITCH

Found in taxon Homo sapiens

Has part(s) C2 domain, WW domain, HECT domain

Imported from wholeness_audit_2026-05-02

Molecular function CXCR chemokine receptor binding, protein binding, ribonucleoprotein complex binding, ubiquitin-like protein transferase activity, transferase activity, ligase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-like protein ligase binding, arrestin family protein binding, ubiquitin protein ligase activity

External References (4)

Ensembl protein id ENSP00000262650, ENSP00000363998, ENSP00000445608, ENSP00000491176, ENSP00000492520

Pdb structure id 2DMV, 2KYK, 2NQ3, 2P4R, 2YSF, 3TUG, 4ROF, 5CQ2, 5DWS, 5DZD, 5C7M

Refseq protein id NP_001244066, NP_001244067, NP_001311126, NP_001311127, NP_113671, XP_005260627, XP_011527381, XP_016883578, XP_016883579, XP_016883580, XP_016883581, XP_024307773

Uniprot protein id Q96J02

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Itchy E3 ubiquitin protein ligase — instance of (P31): protein. Q905695. Retrieved 2019-01-16. wikidata.org.
[3] ↑ Itchy E3 ubiquitin protein ligase — UniProt protein ID (P352): Q96J02. Q905695. Retrieved 2019-01-16. wikidata.org.
[4] ↑ Itchy E3 ubiquitin protein ligase — part of (P361): HECT, E3 ligase catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Itchy E3 ubiquitin protein ligase — part of (P361): WW domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Itchy E3 ubiquitin protein ligase — part of (P361): C2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Itchy E3 ubiquitin protein ligase — part of (P361): E3 ubiquitin-protein ligase, SMURF1 type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Itchy E3 ubiquitin protein ligase — part of (P361): HECT domain, protein family. wikidata.org.
[9] ↑ Itchy E3 ubiquitin protein ligase — part of (P361): C2 domain, protein family. wikidata.org.
[10] ↑ Itchy E3 ubiquitin protein ligase — part of (P361): WW domain, protein family. wikidata.org.
[11] ↑ Itchy E3 ubiquitin protein ligase — has part(s) (P527): C2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Itchy E3 ubiquitin protein ligase — has part(s) (P527): WW domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Itchy E3 ubiquitin protein ligase — has part(s) (P527): HECT domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001244066. Q20641742. Retrieved 2019-02-08. wikidata.org.
[15] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001244067. Q20641742. Retrieved 2019-02-08. wikidata.org.
[16] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001311126. Q20641742. Retrieved 2019-02-08. wikidata.org.
[17] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_001311127. Q20641742. Retrieved 2019-02-08. wikidata.org.
[18] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): NP_113671. Q20641742. Retrieved 2019-02-08. wikidata.org.
[19] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_005260627. Q20641742. Retrieved 2019-02-08. wikidata.org.
[20] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_011527381. Q20641742. Retrieved 2019-02-08. wikidata.org.
[21] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_016883578. Q20641742. Retrieved 2019-02-08. wikidata.org.
[22] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_016883579. Q20641742. Retrieved 2019-02-08. wikidata.org.
[23] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_016883580. Q20641742. Retrieved 2019-02-08. wikidata.org.
[24] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_016883581. Q20641742. Retrieved 2019-02-08. wikidata.org.
[25] ↑ Itchy E3 ubiquitin protein ligase — RefSeq protein ID (P637): XP_024307773. Q20641742. Retrieved 2019-04-12. wikidata.org.
[26] ↑ Itchy E3 ubiquitin protein ligase — PDB structure ID (P638): 2DMV. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ Itchy E3 ubiquitin protein ligase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Itchy E3 ubiquitin protein ligase. Retrieved May 3, 2026, from https://4ort.xyz/entity/itchy-e3-ubiquitin-protein-ligase-q21109507

MLA

“Itchy E3 ubiquitin protein ligase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/itchy-e3-ubiquitin-protein-ligase-q21109507.

BibTeX

@misc{4ortxyz_itchy-e3-ubiquitin-protein-ligase-q21109507_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Itchy E3 ubiquitin protein ligase}}, year = {2026}, url = {https://4ort.xyz/entity/itchy-e3-ubiquitin-protein-ligase-q21109507}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Itchy E3 ubiquitin protein ligase — https://4ort.xyz/entity/itchy-e3-ubiquitin-protein-ligase-q21109507 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/itchy-e3-ubiquitin-protein-ligase-q21109507 · Last refreshed: May 3, 2026